在人体中,大部分色氨酸通过犬尿氨酸途径代谢。这由几种代谢物组成,统称为犬尿氨酸,包括,其中,犬尿酸,L-犬尿氨酸,或喹啉酸。代谢产物的丰富,以及相关的分子靶标和生物学途径,带来一种情况,即使犬尿氨酸水平略有失衡,在外周和中枢神经系统,对一般健康有广泛的影响。辛二酸(CA)是最不为人所知的微量犬尿氨酸,其生理和病理作用尚未得到广泛理解。一些研究,然而,表明它可能具有神经保护作用。有关其肝脏保护特性的信息也出现了,尽管这些是开创性的研究,需要复制。因此,在这次审查中,我的目标是提出和批判性地讨论CA的当前知识及其在生理和病理设置中的作用,以指导未来的研究。
In the human body, the majority of tryptophan is metabolized through the kynurenine pathway. This consists of several metabolites collectively called the kynurenines and includes, among others, kynurenic acid, L-kynurenine, or quinolinic acid. The wealth of metabolites, as well as the associated molecular targets and biological pathways, bring about a situation wherein even a slight imbalance in the kynurenine levels, both in the periphery and central nervous system, have broad consequences regarding general health. Cinnabarinic acid (CA) is the least known trace kynurenine, and its physiological and pathological roles are not widely understood. Some studies, however, indicate that it might be neuroprotective. Information on its hepatoprotective properties have also emerged, although these are pioneering studies and need to be replicated. Therefore, in this review, I aim to present and critically discuss the current knowledge on CA and its role in physiological and pathological settings to guide future studies.