背景:毒物中心制定儿科二甲双胍摄入的分诊阈值指南。我们的网络使用1700毫克,或85毫克/千克。目的:描述剂量,临床课程,我们的全州毒物中心网络报告了5岁及以下儿童意外摄入二甲双胍的结果。方法:我们在2011年至2021年的毒物中心数据库中搜索了5岁及以下患者的二甲双胍摄入量。变量包括年龄,性别,体重,剂量,症状,结果,还有更多.我们对连续变量使用了中位数和四分位数范围(IQR)的描述性统计。结果:669例,按年龄划分的暴露量为208(31.1%)1至2年,和275(41.1%)2年。重量记录为342(51.1%)(中位数13.5公斤;IQR:3.7公斤),剂量为149(22.3%)(中位数500mg;IQR:500mg)。毫克/千克值可用于103(15.4%),中位数为42.4mg/kg,IQR:39mg/kg。大多数(647,98.5%)暴露是无意的。大多数(445/669,66.5%)是在非医疗机构管理的,而204人(30.7%)已经在或转诊到医疗机构。在这204名患者中,169例(82.8%)在急诊科进行了评估和治疗并出院。四人(2%)入院接受重症监护,7人(3.4%)进入病房。按效果分类的医疗结果为5(0.7%)次要,2(0.3%)中度,253(37.8%)无,292(43.6%)未遵循(可能的最小影响),没有重大影响或死亡。在报告的20起临床事件中,呕吐最为常见(8,1.2%).结论:尽管记录的剂量信息很少,85mg/kg以下的儿科二甲双胍摄入主要是平稳的医学结局.
Background: Poison centers develop triage threshold guidelines for pediatric metformin ingestions. Our network uses 1700 mg, or 85 mg/kg. Objective: To describe the dose, clinical course, and outcomes for inadvertent metformin ingestions in children 5 years old and younger reported to our statewide poison center network. Methods: We searched the poison center database 2011 to 2021 for metformin ingestions in patients 5 years and younger. Variables included age, sex, weight, dose, symptoms, outcome, and more. We used descriptive statistics with medians and interquartile ranges (IQR) for continuous variables. Results: Of 669 cases, exposures by age were 208 (31.1%) 1 to 2 years, and 275 (41.1%) 2 years. Weight was recorded in 342 (51.1%) (median 13.5 kg; IQR: 3.7 kg), and dose in 149 (22.3%) (median 500 mg; IQR: 500 mg). Milligram/kilogram values were available for 103 (15.4%) with median 42.4 mg/kg, IQR: 39 mg/kg. Most (647, 98.5%) exposures were unintentional. Most (445/669, 66.5%) were managed at a non-healthcare facility, while 204 (30.7%) were already at or referred to a healthcare facility. Of these 204 patients, 169 (82.8%) were evaluated and treated at the emergency department and discharged. Four (2%) were admitted to critical care, and 7 (3.4%) to the ward. Medical outcomes by effect were 5 (0.7%) minor, 2 (0.3%) moderate, 253 (37.8%) none, 292 (43.6%) not followed (minimal effects possible), and no major effects or deaths. Of 20 clinical occurrences reported, vomiting was most common (8, 1.2%). Conclusion: Despite little recorded dosage information, pediatric metformin ingestions under 85 mg/kg had predominantly uneventful medical outcomes.