一个26岁的人,男性,圈养的洪堡企鹅(Spheniscushumboldti)在消除机制减弱3.5个月的历史后被安乐死,复发性里重,间歇性出血性粪便,和泄殖腔肿块。眼睑痉挛,原因不明,右眼在安乐死前存在约3个月。尸检显示泄殖腔腺癌,伴有局部体腔癌和向肝和肺的远处转移。在组织病理学上,2.6×1.2×0.5-mm,在右视神经周围发现了清晰的肿块,扩大硬膜下空间并包裹软脑膜。肿块由与脑膜瘤一致的肿瘤梭形至多边形细胞组成,脑膜上皮亚型。在视交叉或大脑中没有发现瘤形成的证据,提示原发性球后脑膜瘤.细胞角蛋白AE1/AE3,波形蛋白,S100显示了对波形蛋白的强烈和一致的免疫反应性,以及对细胞角蛋白和S100的弱和可变的免疫反应性,支持诊断。在鸟类中很少描述脑膜瘤,迄今为止,我们在任何鸟类中都没有发现视神经脑膜瘤的报道。在这种情况下,视神经脑膜瘤被认为是临床偶然发现。
A 26-y-old, male, captive Humboldt penguin (Spheniscus humboldti) was euthanized following a 3.5-mo history of weakened elimination mechanics, recurrent tenesmus, intermittent hemorrhagic droppings, and a cloacal mass. Blepharospasm, of unknown cause, of the right eye was present for ~3 mo before euthanasia. Autopsy revealed a cloacal adenocarcinoma with localized coelomic carcinomatosis and distant metastases to the liver and lungs. On histopathology, a 2.6 × 1.2 × 0.5-mm, well-demarcated mass was found surrounding the right optic nerve, expanding the subdural space and wrapping the leptomeninges. The mass was composed of neoplastic spindle-to-polygonal cells consistent with a meningioma,
meningothelial subtype. No evidence of neoplasia was found in the optic chiasm or brain, indicating a primary retrobulbar meningioma. Immunohistochemistry for cytokeratin AE1/AE3, vimentin, and S100 revealed robust and consistent immunoreactivity to vimentin, and weak and variable immunoreactivity to cytokeratin and S100, supporting the diagnosis. Meningiomas have been described only rarely in avian species, and we found no reports of optic nerve meningiomas in any avian species to date. The optic nerve meningioma in this case was considered a clinically incidental finding.