背景:阿尔茨海默病(AD)中的工作记忆缺陷与存储记忆信息的检索障碍有关。然而,关于阿尔茨海默病工作记忆恢复受损机制的研究还很缺乏。
目的:内侧前额叶皮质(mPFC)和内侧丘脑(MD)参与记忆检索。本研究的目的是研究AD模型中mPFC与MD之间的功能相互作用和信息传递。
方法:我们记录了mPFC和MD的局部场电位,而小鼠(APP/PS1转基因模型和对照)执行了T迷宫空间工作记忆任务。在任务阶段评估了mPFC和MD之间的振荡活动和双向信息流的时间动态。
结果:我们主要发现APP/PS1小鼠在检索过程中从mPFC到MD的theta流量显着降低。
结论:我们的结果表明mPFC-MD输入在检索中的重要作用,从mPFC到MD的信息传递中断可能是APP/PS1小鼠工作记忆缺陷的潜在机制。
Working memory deficits in Alzheimer\'s disease (AD) are linked to impairments in the retrieval of stored memory information. However, research on the mechanism of impaired working memory retrieval in Alzheimer\'s disease is still lacking.
The medial prefrontal cortex (mPFC) and mediodorsal thalamus (MD) are involved in memory retrieval. The purpose of this study is to investigate the functional interactions and information transmission between mPFC and MD in the AD model.
We recorded local field potentials from mPFC and MD while the mice (APP/PS1 transgenic model and control) performed a T-maze spatial working memory task. The temporal dynamics of oscillatory activity and bidirectional information flow between mPFC and MD were assessed during the task phases.
We mainly found a significant decrease in theta flow from mPFC to MD in APP/PS1 mice during retrieval.
Our results indicate an important role of the mPFC-MD input for retrieval and the disrupted information transfer from mPFC to MD may be the underlying mechanism of working memory deficits in APP/PS1 mice.