背景:药物相关性脱发的诊断和治疗常常对患者和医师提出挑战。虽然有许多关于这个主题的研究,关于这些研究的强度和规模的信息有限。
目的:我们调查了最常用的处方药物,有大量证据支持与脱发相关。
方法:使用“前100名处方”编制了最常用的处方药清单,销售”(洲际营销服务)和“搜索的前200名”(RxList.com)。PubMed,Embase,和WebofScience搜索“通用药物名称”和“脱发”和“通用药物名称”和“脱发”。“两名审稿人独立审查了药物文章,研究类型和证据水平,以及脱发病例的数量。
结果:共研究了192种独特的药物,110个产生积极的搜索结果。其中,在具有强有力证据的研究中,13例与脱发相关(阿达木单抗,英夫利昔单抗,布地奈德,干扰素β-1α,他克莫司,依诺肝素,带状疱疹疫苗,拉莫三嗪,多西他赛,卡培他滨,厄洛替尼,伊马替尼,和硼替佐米)。
结论:仅包括英语的完整文章。所使用的方法依赖于基于销售的药物清单,而不是处方数量,这可能是昂贵的药物。
结论:关于药物相关性脱发的研究很少有高水平的证据。必须进一步确定脱发的机制以提供有效的管理。
The diagnosis and treatment of medication-associated alopecia often challenges patients and physicians. While numerous studies on the topic exist, limited information on the strength and magnitude of these studies exists.
We investigated the most commonly prescribed medications with high levels of evidence to support associations with alopecia.
A list of most commonly prescribed medications was compiled using the \"Top 100 Prescriptions, Sales\" (Intercontinental Marketing Services) and \"Top 200 Names Searched\" (RxList.com). PubMed, Embase, and Web of Science were searched for \"generic drug name\" AND \"alopecia\" and \"generic drug name\" AND \"hair loss.\" Two reviewers independently reviewed articles for drug, study type and level of evidence, and number of alopecia cases.
A total of 192 unique drugs were investigated, with 110 yielding positive search results. Of these, 13 were associated with alopecia in studies with strong levels of evidence (adalimumab, infliximab, budesonide, interferon β-1α, tacrolimus, enoxaparin, zoster vaccine, lamotrigine, docetaxel, capecitabine, erlotinib, imatinib, and bortezomib).
Only full-length articles available in the English language were included. The methodology used relied on lists of drugs based on their sales rather than number of prescriptions, which likely overrepresented expensive drugs.
Few studies with high levels of evidence have been conducted on the topic of medication-associated alopecia. The mechanisms of hair loss must be further identified to provide effective management.