■青少年抑郁症可能有慢性病程;因此,强调了坚持抗抑郁药物治疗对成功治疗结局的重要性.这项研究旨在检查不同的依从性措施,并确定影响青少年抑郁症依从性的临床因素。
■根据《精神障碍诊断和统计手册》,对被诊断患有抑郁症的患者进行了一项前瞻性研究,第四版来自韩国大学医学中心的门诊精神病设置,Guro医院.患者的人口统计数据是从问卷中获得的,采访,并审查图表记录。通过四种方法评估依从性(药物事件监测系统[MEMS],药丸计数,临床评定量表,和患者的自我报告)。多伦多副作用量表用于评估副作用,和特定的抑郁症状使用汉密尔顿抑郁量表和儿童抑郁量表-韩国版本进行评估。运用多维领悟社会支持量表分析社会支持,父母压力指数简表用于评估父母的压力水平。我们使用一致性相关分析来评估四种依从性措施之间的关系以及依从性水平与临床因素之间的关系。
■总的来说,该研究纳入了48例门诊患者(平均年龄16.33±1.93岁).平均病程为1.27±2.17年。MEMS的遵守率,临床医生评定量表,药丸计数,转换为二分法后的自我报告为67.5%,48.9%,60.0%,和56.3%,分别。仅疾病持续时间与MEMS保持显着相关(r=0.510,p=0.001)。
■与其他两种依从性措施相比,药丸计数与MEMS依从性表现出更高的一致性,可能表明药丸计数可能是相当可靠的依从性量度。此外,MEMS依从性与疾病持续时间呈正相关,这表明疾病的持续时间越长,依从性越高。
UNASSIGNED: Adolescent depression can have a chronic course; hence, the importance of adherence to antidepressant medication for successful treatment outcomes is emphasized. This study aimed to examine different adherence measures and identify clinical factors that influence adherence in adolescent depression.
UNASSIGNED: A prospective study was conducted for patients diagnosed with depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorder, Fourth Edition from outpatient psychiatric settings at Korea University Medical Center, Guro Hospital. Patient demographics were obtained from a questionnaire, interview, and review of chart records. Adherence was assessed by four methods (Medication Event Monitoring System [MEMS], pill count, clinical rating scale, and patient\'s self-report). The Toronto Side Effect Scale was used to evaluate side effects, and specific depressive symptoms were assessed using the Hamilton Rating Scale for Depression and Childhood Depression Inventory-Korean version. The Multidimensional Scale of Perceived Social Support was administered to analyze social support, and the Parenting Stress Index-Short Form was used to evaluate parental stress levels. We used concordance correlation analysis to evaluate the relationship among the four adherence measures and the relationship between adherence level and clinical factors.
UNASSIGNED: Overall, the study enrolled 48 outpatients (mean age 16.33±1.93 years). The mean duration of illness was 1.27±2.17 years. Adherence rates for MEMS, clinician rating scale, pill count, and self-report after conversion to dichotomous measures were 67.5%, 48.9%, 60.0%, and 56.3%, respectively. Only the duration of illness remained significantly correlated with MEMS (r = 0.510, p =0.001).
UNASSIGNED: Pill count exhibited a higher degree of agreement with MEMS adherence than the other two adherence measures, possibly indicating that pill count may be a considerably reliable measure of adherence. Furthermore, MEMS adherence was positively correlated with disease duration, suggesting that the longer the duration of illness, the higher the adherence.