mechanical-electric feedback

  • 文章类型: Case Reports
    心房颤动(AF)是临床实践中最常见的心律失常之一。负责其发展的病理生理机制是复杂的,因个人而异,并与诱发因素有关。这里,我们报告一例由环状缩窄性心包炎(ACP)引起的房颤,由于其不寻常的解剖形式,这是极其罕见的。在我们的病人身上,AF对多种抗心律失常药物是难治性的;然而,当沿着房室(AV)沟环绕右心室和左心室(RV和LV)腔的环被切断时,发生了自发的窦性心律转换。这表明,由于心房扩大和左心房(LA)压力增加导致的心房拉伸可能有助于房颤的启动和维持。本报告强调了使用非侵入性诊断方法和机械电反馈(MEF)作为房颤启动和维持的病理生理机制,仔细研究房颤的罕见诱发因素的重要性。
    Atrial fibrillation (AF) is one of the most common arrhythmias encountered in clinical practice. The pathophysiological mechanisms responsible for its development are complex, vary amongst individuals, and associated with predisposing factors. Here, we report a case of AF caused by annular constrictive pericarditis (ACP), which is extremely rare due to its unusual anatomical form. In our patient, AF was refractory to multiple antiarrhythmic medications; however, spontaneous conversion to sinus rhythm occurred when the ring encircling the right and left ventricular (RV and LV) cavities along the atrioventricular (AV) groove was severed. This suggests that atrial stretch due to atrial enlargement and increased left atrial (LA) pressure may contribute to the initiation and maintenance of AF. This report highlights the importance of the careful investigation of rare predisposing factors for AF using non-invasive diagnostic approaches and mechanical-electric feedback (MEF) as a pathophysiological mechanism for AF initiation and maintenance.
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  • 文章类型: Case Reports
    电风暴(ES)仍然是临床医生的主要困境,通常表现为与重大不良结果相关的医疗紧急情况。触发ES背后的机制是复杂的。尽管交感神经系统激活的增加被广泛认为是启动和维持ES的主要机制,它认为,机械和电气基板之间的相互作用可能在某些情况下发挥重要作用。在这里,我们介绍了一种对多种抗心律失常药物难以治疗但因房间分流而停止的ES。我们的目标是强调机械电反馈(MEF)作为某些类型ES的病理生理机制的重要性,以及在有证据表明左心室充盈压或左心房压升高时,心房分流作为最初对抗心律失常药物难治性ES患者的替代治疗策略的实用性。
    Electrical storm (ES) remains a major dilemma for clinicians, often presenting as a medical emergency associated with significant adverse outcomes. The mechanisms behind triggering ES are complex. Although the increased activation of the sympathetic nervous system was widely accepted as a major mechanism in initiating and maintaining ES, it\'s thought that the interaction between mechanical and electrical substrates may play an important role in some situations. Here we present a case of ES that was refractory to multiple antiarrhythmic medications but was stopped by interatrial shunting. We aim to highlight the importance of mechano-electric feedback (MEF) as the pathophysiological mechanisms of some types of ES and the utility of interatrial shunting as an alternative therapeutic strategy for patients with ES initially refractory to antiarrhythmic medications when there is evidence to indicate increased left ventricular filling pressure or left atrial pressure.
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