心血管风险增加与某些血小板形态学参数有关,和几个单核苷酸多态性(SNP)已被报道。尽管如此,对其在1型糖尿病(T1DM)儿童中的作用知之甚少。所以,我们旨在研究T1DM患儿血小板参数和血脂变化与rs7961894SNP的关系.80名T1DM儿童和80名明显健康的对照者参加了这项横断面研究。血小板计数,平均血小板体积(MPV),血小板分布宽度(PDW),plateletcrit(PCT),HbA1c,甘油三酯,总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),测量高密度脂蛋白胆固醇,并计算了动脉粥样硬化指数。使用实时聚合酶链等位基因识别技术,对rs7961894SNP进行基因分型。T1DM患儿MPV明显增高,PDW,TC,和LDL-C与对照组相比。25%的患者有rs7961894CT基因型,MPV明显增高,PDW,PCT,LDL-C,甘油三酯,Castelli的风险指数II(CRIII),和血浆动脉粥样硬化指数(AIP)与CC基因型患者的比较。MPV与CRIII和AIP显著相关,带有CRIII的PDW,而PCT与HbA1c显著相关,LDL-C,CRIII,和AIP。rs7961894CT基因型是MPV变化的显著依赖预测因子,PDW,和PCT在多元回归分析中的应用。结论:在儿童T1DM中,rs7961894CT基因型与MPV显著相关,PDW,和PCT的变化,这表明与CRIII和AIP有实质性的关系,强调监测这些患者以及早发现潜在心血管风险的重要性.已知内容:•血小板和血脂异常与动脉粥样硬化的发病机制有关•糖尿病中血小板活性和形态学参数的变化是矛盾的•rs7961894单核苷酸多态性与平均血小板体积(MPV)的显着变化相关,没有可用的数据在儿童中什么是新的:•1型糖尿病儿童表现出明显更高的MPV值和血小板分布宽度(PDW)•rs7961894基因型是MPV变化的依赖性PDW,和plateletcrit(PCT)值•rs7961894CT基因型的糖尿病儿童显示脂质参数的实质性改变,MPV之间有很强的相关性,PDW,PCT和Castelli的风险指数II和血浆致动脉粥样硬化指数。
Increased cardiovascular risk has been associated with certain platelet morphological parameters, and several single nucleotide polymorphisms (SNPs) have been reported to be linked. Still, little is known about their role among children with type 1 diabetes mellitus (T1DM). So, we aimed to investigate platelet parameters and lipid profile changes in relation to rs7961894 SNP in children with T1DM. Eighty children with T1DM and eighty apparently healthy controls participated in this cross-sectional study. Platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), HbA1c, triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol were measured, and atherogenic indices were calculated. Using a real-time polymerase chain allelic discrimination technique, rs7961894 SNP was genotyped. Children with T1DM had significantly higher MPV, PDW, TC, and LDL-C compared to controls. 25% of patients had rs7961894 CT genotype with significantly higher MPV, PDW, PCT, LDL-C, triglycerides, Castelli\'s risk index II (CRI II), and atherogenic index of plasma (AIP) compared to CC genotyped patients. MPV correlated significantly with CRI II and AIP, PDW with CRI II, while PCT correlated substantially with HbA1c, LDL-C, CRI II, and AIP. rs7961894 CT genotype was a significant dependent predictor of the changes in MPV, PDW, and PCT in multivariate regression analysis.Conclusion: In children with T1DM, rs7961894 CT genotype is significantly linked to MPV, PDW, and PCT changes, which showed a substantial relationship to CRI II and AIP, highlighting the importance of monitoring these patients to identify potential cardiovascular risks early. What is Known: • Platelets and dyslipidemia are involved in atherosclerosis pathogenesis • Changes in platelet activity and morphological parameters in diabetes mellitus are contradictory • rs7961894 single nucleotide polymorphism is associated with significant changes in mean platelet volume (MPV) with no available data in children What is New: • Children with type 1 diabetes mellitus exhibited significantly higher values of MPV and platelet distribution width (PDW) • rs7961894 CT genotype was a dependent predictor of the changes in MPV, PDW, and plateletcrit (PCT) values • Diabetic children with the rs7961894 CT genotype showed substantial alterations in lipid parameters with a strong correlation between MPV, PDW, and PCT and Castelli\'s risk index II and the atherogenic index of plasma.