■血液重金属水平与潜伏性结核感染(LTBI)之间的关系尚未完全阐明。这项研究的目的是使用2011年至2012年的国家健康和营养检查调查数据,调查成年人血液重金属水平与LTBI之间的潜在关联。
■我们在这项研究中招募了1710名参与者,并比较参与者的基线特征。多因素Logistic回归分析,受限三次样条(RCS)分析,我们利用亚组分析和交互作用检验来探索血锰(Mn)水平与LTBI风险之间的关联.
■与非LTBI个体相比,LTBI参与者的血锰水平更高(p<0.05),而铅的水平,镉,总汞,硒,铜,锌和锌在两组之间没有显着差异(p>0.05)。在完全调整的模型中,随着血Mn水平每增加1个单位,LTBI风险略有增加(OR=1.00,95%CI:1.00-1.01,p=0.02).与最低四分位数的参与者相比,最高四分位数的参与者的LTBI风险增加了三倍(OR=4.01,95%CI:1.22-11.33,p=0.02)。RCS分析未显示血液Mn水平与LTBI之间的非线性关系(非线性p值=0.0826)。亚组分析和相互作用测试表明,年龄,酒精消费,收入与贫困比率显著影响LTBI风险(交互作用p值<0.05)。
■患有LTBI的人比非LTBI的人有更高的血锰水平,和较高的血锰水平与LTBI风险增加相关。
UNASSIGNED: The associations between blood heavy metal levels and latent tuberculosis infection (LTBI) have not been fully elucidated. The aim of this study was to investigate the potential association between blood heavy metal levels and LTBI in adults using National Health and Nutrition Examination Survey data from 2011 to 2012.
UNASSIGNED: We enrolled 1710 participants in this study, and compared the baseline characteristics of participants involved. Multivariate logistic regression analysis, restricted cubic splines (RCS) analysis, along with subgroup analysis and interaction tests were utilized to explore the association between blood
manganese (Mn) level and LTBI risk.
UNASSIGNED: Participants with LTBI had higher blood Mn level compared to non-LTBI individuals (p < 0.05), while the levels of lead, cadmium, total mercury, selenium, copper, and zinc did not differ significantly between the two groups (p > 0.05). In the fully adjusted model, a slight increase in LTBI risk was observed with each 1-unit increase in blood Mn level (OR = 1.00, 95% CI: 1.00-1.01, p = 0.02). Participants in the highest quartile of blood Mn level had a threefold increase in LTBI risk compared to those in the lowest quartile (OR = 4.01, 95% CI: 1.22-11.33, p = 0.02). RCS analysis did not show a non-linear relationship between blood Mn level and LTBI (non-linear p-value = 0.0826). Subgroup analyses and interaction tests indicated that age, alcohol consumption, and income-to-poverty ratio significantly influenced LTBI risk (interaction p-values<0.05).
UNASSIGNED: Individuals with LTBI had higher blood Mn level compared to non-LTBI individuals, and higher blood Mn level associated with increased LTBI risk.