malnutrition risk

  • 文章类型: Journal Article
    背景:关于接受家庭护理(HC)和非卧床护理(AC)服务的患者中营养不良的患病率知之甚少。Further,从医院转行HC或AC的营养不良患者的再入院风险也未得到很好的确定.本研究旨在解决这两个差距。
    方法:对2019年1月至12月新转诊的HC和AC患者进行了描述性队列研究。临床医生使用迷你营养评估简表(MNA-SF)评估营养状况。计算了营养不良和营养不良风险(ARM)的患病率,使用对数二项回归模型估计营养不良患者出院后30天内再入院的相对风险.
    结果:总共返回了3704个MNA-SF,其中2402人(65%)有完整的数据。新转诊的HC和AC患者中营养不良和ARM的估计患病率为21%(95%CI:19%-22%)和55%(95%CI:53%-57%),分别。营养不良患者的估计再入院风险比营养状态正常患者高2.7倍(95%CI:1.9%-3.9%),ARM患者的估计再入院风险高1.9倍(95%CI:1.4%-2.8%)。
    结论:HC和AC患者中营养不良和ARM的患病率较高。营养不良和ARM与出院后30天再次入院的风险增加相关。
    BACKGROUND: Little is known about the prevalence of malnutrition among patients receiving home care (HC) and ambulatory care (AC) services. Further, the risk of hospital readmission in malnourished patients transitioning from hospital to HC or AC is also not well established. This study aims to address these two gaps.
    METHODS: A descriptive cohort study of newly referred HC and AC patients between January and December 2019 was conducted. Nutrition status was assessed by clinicians using the Mini Nutritional Assessment-Short Form (MNA-SF). Prevalence of malnutrition and at risk of malnutrition (ARM) was calculated, and a log-binomial regression model was used to estimate the relative risk of hospital readmission within 30 days of discharge for those who were malnourished and referred from hospital.
    RESULTS: A total of 3704 MNA-SFs were returned, of which 2402 (65%) had complete data. The estimated prevalence of malnutrition and ARM among newly referred HC and AC patients was 21% (95% CI: 19%-22%) and 55% (95% CI: 53%-57%), respectively. The estimated risk of hospital readmission for malnourished patients was 2.7 times higher (95% CI: 1.9%-3.9%) and for ARM patients was 1.9 times higher (95% CI: 1.4%-2.8%) than that of patients with normal nutrition status.
    CONCLUSIONS: The prevalence of malnutrition and ARM among HC and AC patients is high. Malnutrition and ARM are correlated with an increased risk of hospital readmission 30 days posthospital discharge.
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  • 文章类型: Journal Article
    胃切除术和食管切除术是食管癌和胃癌治疗中执行最多的手术。食管切除术的类型取决于恶性肿瘤的类型,肿瘤的部位,切除标准,和切除领域。食管切除术的三种标准方法是经食管切除术,左侧胸腹入路,和三个阶段的程序。经产入路包括腹部和颈部切口,而左胸腹入路是一个阶段的手术,利用单个切口暴露夹层区域。IvorLewis和McKeown食管切除术是两阶段和三阶段手术,包括开腹手术和右开胸手术。食管切除术和胃切除术后,吸收不良通常是严重的术后并发症。与这些癌症有关的营养不良会产生有害影响,包括术后并发症的发生率升高,感染风险升高,伤口愈合延迟,对治疗的耐受性降低,生活质量下降,死亡率上升。我们的叙事综述总结并阐明了治疗胃旁路手术后吸收不良和营养不良的解决方案。这些解决方案包括调整等方法,补充剂,和治疗。尽管需要更多的研究来证实它们的有效性,这些方法表明有可能降低对患者饮食的影响。通过考虑这些影响的有益影响并考虑解决方案,我们的目标是改善这些不利影响的管理,最终改善患者的整体健康状况和术后结局。
    Gastrectomy and esophagectomy are the most performed surgeries in the treatment of both esophageal and gastric cancers. The type of esophagectomy depends on the type of malignancy, site of the tumor, criteria of resection, and field of resection. The three standard approaches to esophagectomy are the transhiatal approach, the left thoracoabdominal approach, and a three-stage procedure. The transhiatal approach involves abdominal and cervical incisions, while the left thoracoabdominal approach is a one-stage procedure that utilizes a single incision exposing the dissection field. The Ivor Lewis and McKeown esophagectomies are two-stage and three-stage surgeries that include laparotomy with right thoracotomy. Malabsorption often emerges as a significant postoperative complication following esophagectomy and gastrectomy surgeries. Malnutrition linked with these cancers has detrimental effects, including heightened rates of postoperative complications, elevated infection risks, delayed wound healing, reduced tolerance to treatment, diminished quality of life, and heightened mortality rates. Our narrative review summarizes and sheds light on solutions to treat malabsorption disorders and malnutrition after gastric bypass surgery. These solutions include methods such as adjustments, supplements, and treatment. Although more research is needed to confirm their effectiveness, these methods indicate potential for lowering the impact on patients\' diets. By considering the beneficial implications of these effects and considering solutions, we aim to improve the management of these adverse effects, ultimately improving the overall health and postoperative outcomes of patients.
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  • 文章类型: Case Reports
    营养性视神经病变是一种罕见且经常被忽视的因素,对称,和逐渐的视力障碍。这种情况属于代谢性神经病的范畴。我们记录了一例涉及归因于与维生素B12缺乏相关的全血细胞减少症的双侧营养性视神经病变。一名健康的65岁印度妇女报告说,进步,过去六个月视力无痛下降。她在前一年有口服摄入量减少的病史,并且否认有任何胃肠道或全身症状。双侧视力为1/60。检查显示视盘苍白,双眼血管衰减,杯盘比为0.3。血液分析显示指标低,血清维生素B12缺乏。尽管正在接受治疗,由于病情的慢性,她的视力仍然受损。这个案例突出了识别因饮食习惯不适当而导致营养不良的老年妇女的视觉症状的重要性,导致双侧营养性视神经病变。
    Nutritional optic neuropathy is a rare and often overlooked factor leading to bilateral, symmetrical, and gradual visual impairment. This condition falls within the category of metabolic neuropathies. We documented a case involving bilateral nutritional optic neuropathy attributed to pancytopenia associated with vitamin B12 deficiency. A healthy 65-year-old Indian woman reported a bilateral, progressive, painless decline in vision over the past six months. She had a history of reduced oral intake for the preceding year and denied experiencing any gastrointestinal or constitutional symptoms. Bilateral visual acuity was 1/60. Examination revealed pale optic discs with attenuated vessels in both eyes and a cup-disc ratio of 0.3. The blood analysis showed low indices and a deficiency in serum vitamin B12. Despite undergoing treatment, her vision remained impaired due to the chronic nature of the condition. This case highlights the importance of identifying visual symptoms in an elderly woman experiencing malnutrition caused by inadequate dietary habits, which leads to bilateral nutritional optic neuropathy.
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  • 文章类型: Journal Article
    目的:研究与营养风险评分变化相关的社会网络因素,用SCREEN-8衡量,超过三年,居住在社区的45岁及以上的加拿大人,使用加拿大老龄化纵向研究(CLSA)的数据。方法:通过从基线评分中减去随访时的SCREEN-8评分,计算CLSA基线与首次随访波之间SCREEN-8评分的变化。采用多变量线性回归分析SCREEN-8评分变化的相关因素。结果:基线时的平均SCREEN-8评分为38.7(SD=6.4),随访时平均SCREEN-8评分为37.9分(SD=6.6)。SCREEN-8评分的平均变化为-0.90(SD=5.99)。更高水平的社会参与(参与社区活动)与基线和随访之间SCREEN-8分数的增加有关。三年后.结论:营养师应该意识到,社会参与水平低的人可能会面临营养状况随着时间的推移而下降的风险,因此应考虑对他们进行积极的营养风险筛查。营养师可以制定和支持旨在将食物与社会参与相结合的计划。
    Purpose: To examine the social network factors associated with changes in nutrition risk scores, measured by SCREEN-8, over three years, in community-dwelling Canadians aged 45 years and older, using data from the Canadian Longitudinal Study on Aging (CLSA).Methods: Change in SCREEN-8 scores between the baseline and first follow-up waves of the CLSA was calculated by subtracting SCREEN-8 scores at follow-up from baseline scores. Multivariable linear regression was used to examine the factors associated with change in SCREEN-8 score.Results: The mean SCREEN-8 score at baseline was 38.7 (SD = 6.4), and the mean SCREEN-8 score at follow-up was 37.9 (SD = 6.6). The mean change in SCREEN-8 score was -0.90 (SD = 5.99). Higher levels of social participation (participation in community activities) were associated with increases in SCREEN-8 scores between baseline and follow-up, three years later.Conclusions: Dietitians should be aware that individuals with low levels of social participation may be at risk for having their nutritional status decrease over time and consideration should be given to screening them proactively for nutrition risk. Dietitians can develop and support programs aimed at combining food with social participation.
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  • 文章类型: Journal Article
    背景:在高收入国家,65%至70%的65岁及以上的社区居住成年人处于高营养风险中。营养风险是指不良饮食摄入和营养状况的风险。高营养风险的后果包括虚弱,住院治疗,死亡,降低了生活质量。社会因素(如社会支持和共情)是已知的影响饮食行为在以后的生活;然而,根据作者的知识,没有进行过专门研究这些社会因素与营养风险之间的相关性的综述.
    目的:本范围综述的目的是了解有关高收入国家(HIC)社区居住老年人的社会因素与营养风险之间关系的证据的范围和类型,并确定解决HIC社区居住老年人营养风险的社会干预措施。
    方法:本综述将遵循JBI证据综合手册所概述的范围审查方法,和PRISMA-ScR(系统审查的首选报告项目和范围审查的荟萃分析扩展)指南。搜索将包括MEDLINE,CINAHL,PsychInfo,和WebofScience。搜索没有日期限制。然而,仅包含英语资源。EndNote和Covidence将用于参考管理和删除重复研究。文章将被筛选,以及至少2名独立审稿人使用Covidence提取的数据。要提取的数据将包括研究特征(国家,方法,目标,设计,dates),参与者特征(人口描述,纳入和排除标准,招聘方法,参与者总数,人口统计),如何测量营养风险(包括用于测量营养风险的工具),检查的社会因素或干预措施(包括如何测量或确定这些因素),营养风险与社会因素之间的关系,以及旨在解决营养风险的社会干预措施的细节。
    结果:范围审查于2023年10月开始,并将于2024年8月完成。研究结果将描述营养风险文献中通常检查的社会因素,这些社会因素与营养风险之间的关系,影响营养风险的社会因素,以及旨在解决营养风险的社会干预措施。提取的数据的结果将以叙述性总结的形式和随附的表格呈现。
    结论:鉴于高收入国家社区老年人的营养风险患病率高以及营养风险的负面影响,了解与营养风险相关的社会因素至关重要。预计审查结果将有助于确定应积极筛查营养风险的个人,并为计划提供信息。政策,以及旨在降低营养风险患病率的干预措施。
    背景:
    BACKGROUND: In high-income countries (HICs), between 65% and 70% of community-dwelling adults aged 65 and older are at high nutrition risk. Nutrition risk is the risk of poor dietary intake and nutritional status. Consequences of high nutrition risk include frailty, hospitalization, death, and reduced quality of life. Social factors (such as social support and commensality) are known to influence eating behavior in later life; however, to the authors\' knowledge, no reviews have been conducted examining how these social factors are associated with nutrition risk specifically.
    OBJECTIVE: The objective of this scoping review is to understand the extent and type of evidence concerning the relationship between social factors and nutrition risk among community-dwelling older adults in HICs and to identify social interventions that address nutrition risk in community-dwelling older adults in HICs.
    METHODS: This review will follow the scoping review methodology as outlined by the JBI Manual for Evidence Synthesis and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines. The search will include MEDLINE (Ovid), CINAHL, PsycINFO, and Web of Science. There will be no date limits placed on the search. However, only resources available in English will be included. EndNote (Clarivate Analytics) and Covidence (Veritas Health Innovation Ltd) will be used for reference management and removal of duplicate studies. Articles will be screened, and data will be extracted by at least 2 independent reviewers using Covidence. Data to be extracted will include study characteristics (country, methods, aims, design, and dates), participant characteristics (population description, inclusion and exclusion criteria, recruitment method, total number of participants, and demographics), how nutrition risk was measured (including the tool used to measure nutrition risk), social factors or interventions examined (including how these were measured or determined), the relationship between nutrition risk and the social factors examined, and the details of social interventions designed to address nutrition risk.
    RESULTS: The scoping review was started in October 2023 and will be finalized by August 2024. The findings will describe the social factors commonly examined in the nutrition risk literature, the relationship between these social factors and nutrition risk, the social factors that have an impact on nutrition risk, and social interventions designed to address nutrition risk. The results of the extracted data will be presented in the form of a narrative summary with accompanying tables.
    CONCLUSIONS: Given the high prevalence of nutrition risk in community-dwelling older adults in HICs and the negative consequences of nutrition risk, it is essential to understand the social factors associated with nutrition risk. The results of the review are anticipated to aid in identifying individuals who should be screened proactively for nutrition risk and inform programs, policies, and interventions designed to reduce the prevalence of nutrition risk.
    UNASSIGNED: DERR1-10.2196/56714.
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  • 文章类型: Journal Article
    慢性肾脏病(CKD)的患病率正在上升,尤其是老年人。CKD和衰老之间的重叠与身体成分改变有关,代谢异常,和营养不良。肾脏护理指南建议根据肾脏疾病阶段用低蛋白饮食治疗CKD患者。另一方面,老年护理指南强调需要更高的蛋白质摄入量来预防营养不良。如何在老年CKD人群中调和低膳食蛋白质摄入量与确保有利的营养状况仍然是挑战。因此,本研究旨在评估低蛋白充足能量摄入(LPAE)饮食对老年CKD(3~5期)患者营养风险和营养状况的影响,然后评估其对CKD代谢异常的影响.为此,42名受试者[年龄≥65岁,保守治疗CKD3-5期,和老年营养风险指数(GNRI)≥98]被招募,并规定了LPAE饮食。在基线和LPAE饮食6个月后,收集了以下数据:年龄,性别,生化参数,人体测量,身体成分,GNRI。根据他们的饮食依从性,受试者被分为两组:依从性和非依从性.对于合规组,获得的结果表明,没有增加营养不良的风险发生率,但是,更确切地说,身体成分和代谢参数的改善,表明LPAE饮食可以为老年CKD患者提供安全的工具。
    The prevalence of chronic kidney disease (CKD) is rising, especially in elderly individuals. The overlap between CKD and aging is associated with body composition modification, metabolic abnormalities, and malnutrition. Renal care guidelines suggest treating CKD patient with a low-protein diet according to the renal disease stage. On the other hand, geriatric care guidelines underline the need for a higher protein intake to prevent malnutrition. The challenge remains of how to reconcile a low dietary protein intake with insuring a favorable nutritional status in geriatric CKD populations. Therefore, this study aims to evaluate the effect of a low-protein adequate energy intake (LPAE) diet on nutritional risk and nutritional status among elderly CKD (stage 3-5) patients and then to assess its impact on CKD metabolic abnormalities. To this purpose, 42 subjects [age ≥ 65, CKD stage 3-5 in conservative therapy, and Geriatric Nutritional Risk Index (GNRI) ≥ 98] were recruited and the LPAE diet was prescribed. At baseline and after 6 months of the LPAE diet, the following data were collected: age, sex, biochemical parameters, anthropometric measurements, body composition, and the GNRI. According to their dietary compliance, the subjects were divided into groups: compliant and non-compliant. For the compliant group, the results obtained show no increased malnutrition risk incidence but, rather, an improvement in body composition and metabolic parameters, suggesting that the LPAE diet can provide a safe tool in geriatric CKD patients.
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  • 文章类型: Meta-Analysis
    背景:衰老和痴呆是老年人常见且密切相关的健康问题,影响他们维持健康饮食的能力,最终导致营养不良。
    目的:在本研究中,我们估计了全球营养不良患病率和老年痴呆患者营养不良风险.
    方法:Meta分析。
    方法:Embase,OvidMEDLINE,PubMed,CINAHL,Scopus,和WebofScience进行了全面搜索,查找从数据库开始到2022年10月发表的文章。
    方法:使用广义线性混合模型和随机效应模型进行汇总患病率分析。I2和Cochran的Q统计量用于识别异质性。使用Peters回归检验和漏斗图评估发表偏倚。进行了主持人分析,以调查纳入研究的患病率估计值的变化。所有统计分析均使用R软件进行。
    结果:共有16项研究纳入分析,涉及6513名老年痴呆症患者。结果表明,32.52%(95%置信区间:19.55-45.49)的所有包括老年痴呆症患者营养不良,而46.80%(95%置信区间:38.90-54.70)有营养不良的风险。在住院环境中的老年患者(46.59%)和阿尔茨海默病患者(12.26%)中,营养不良的患病率很高。调节营养不良患病率的因素包括充足的维生素B12摄入量,风险行为,医疗合并症,和某些神经精神症状.营养不良风险在女性(29.84%)和阿尔茨海默病患者(26.29%)中的患病率较高。调节营养不良风险患病率的因素包括总胆固醇水平,维生素B12的消费,风险行为,医疗合并症,和某些神经精神症状.
    结论:大约三分之一的老年痴呆症患者营养不良,近一半的老年人有营养不良的风险。鼓励卫生保健专业人员之间的合作,确保早期评估和有效管理营养不良,对于保持老年痴呆症患者良好的营养状况至关重要。
    背景:本研究已在国际前瞻性系统审查注册中心(PROSPERO:CRD420223669329)注册。
    结论:全球,约32.52%的老年痴呆症患者营养不良,约46.80%有营养不良风险.
    BACKGROUND: Aging and dementia are common and closely related health problems in older adults, affecting their ability to maintain a healthy diet and ultimately resulting in malnutrition.
    OBJECTIVE: In this study, we estimated the global prevalence of malnutrition and malnutrition risk in older adults with dementia.
    METHODS: Meta-analysis.
    METHODS: Embase, Ovid MEDLINE, PubMed, CINAHL, Scopus, and Web of Science were comprehensively searched for articles published from database inception to October 2022.
    METHODS: Pooled prevalence analysis was conducted using a generalized linear mixed model and a random-effects model. I2 and Cochran\'s Q statistics were used for identifying heterogeneity. Publication bias was evaluated using Peters\' regression test and a funnel plot. Moderator analyses were conducted to investigate variations in the prevalence estimates of the included studies. All statistical analyses were conducted using R software.
    RESULTS: A total of 16 studies involving a total of 6513 older adults with dementia were included in the analysis. The results indicated that 32.52 % (95 % confidence interval: 19.55-45.49) of all included older adults with dementia had malnutrition, whereas 46.80 % (95 % confidence interval: 38.90-54.70) had a risk of malnutrition. The prevalence of malnutrition was found to be high among older patients living in institutionalized settings (46.59 %) and those with Alzheimer\'s disease (12.26 %). The factors moderating the prevalence of malnutrition included adequate vitamin B12 consumption, risk behaviors, medical comorbidities, and certain neuropsychiatric symptoms. The prevalence of malnutrition risk was high among women (29.84 %) and patients with Alzheimer\'s disease (26.29 %). The factors moderating the prevalence of malnutrition risk included total cholesterol level, vitamin B12 consumption, risk behaviors, medical comorbidities, and certain neuropsychiatric symptoms.
    CONCLUSIONS: Approximately one-third of older adults with dementia are malnourished and nearly half of older adults are at a risk of malnutrition. Encouraging collaboration among health-care professionals and ensuring early assessment and effective management of malnutrition are crucial for maintaining a favorable nutritional status in older adults with dementia.
    BACKGROUND: This study was registered with the International Prospective Register of Systematic Reviews (PROSPERO: CRD42022369329).
    CONCLUSIONS: Globally, approximately 32.52 % of older adults with dementia are malnourished and approximately 46.80 % are at a risk of malnutrition.
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  • 文章类型: Journal Article
    本研究旨在调查与社区中体弱多病和体弱多病的老年人认知虚弱相关的健康因素。
    总共包括233名符合Fried的虚弱或虚弱标准的老年人。使用简短的便携式精神状态问卷评估认知状态。健康因素包括营养状况(使用迷你营养评估工具进行评估,身体质量指数,和腰部,手臂,和腿部周长),身体功能(用短物理性能电池评估),生活质量(用EuroQoL5维度5级问卷的总指数-EQoL指数-,和视觉模拟量表-QoL-VAS-适用于当今的健康状况),除了睡眠,身体活动,以及通过手腕佩戴的加速度计估计的不活动。进行了多变量逻辑回归分析,以确定认知虚弱的潜在预测因子,认为年龄是一个混杂因素。
    认知脆弱的参与者表现出高龄,自我报告的疲惫加剧,整体物理性能下降,减少腿部周长,减少对中等至剧烈体力活动的参与,和更高水平的不活动(所有p<0.05)。然而,在调整了年龄之后,只有QoL-VAS作为认知脆弱的危险因素出现(赔率比:1.024),而EQoL指数,小腿周边,和中等至剧烈的体力活动水平被确定为保护因素(赔率比:0.025,0.929和0.973,分别)。
    这项研究强调了诸如年龄,和可改变的因素,包括生活质量,营养状况,和体力活动在社区中具有虚弱表型的老年人的认知虚弱发展中的作用。
    UNASSIGNED: This study aims to investigate the health factors associated with cognitive frailty in frail and pre-frail older adults living in the community.
    UNASSIGNED: A total of 233 older adults meeting Fried\'s criteria for pre-frailty or frailty were included. Cognitive status was evaluated using the Short Portable Mental Status Questionnaire. Health factors encompassed nutritional status (evaluated using the Mini Nutritional Assessment tool, body mass index, and waist, arm, and leg circumferences), physical function (assessed with the Short Physical Performance Battery), quality of life (measured with the total index of the EuroQoL 5-Dimension 5-Level questionnaire - EQoL-Index -, and the Visual-Analogue Scale - QoL-VAS - for today\'s health state), as well as sleep, physical activity, and inactivity estimated through wrist-worn accelerometers. Multivariable logistic regression analyses were conducted to identify potential predictors of cognitive frailty, considering age as a confounding factor.
    UNASSIGNED: Cognitive frail participants exhibited advanced age, heightened self-reported exhaustion, diminished overall physical performance, reduced leg perimeter, decreased engagement in moderate-to-vigorous physical activity, and higher levels of inactivity (all p<0.05). However, after adjusting for age, only QoL-VAS emerged as a cognitive frailty risk factor (Odds ratio: 1.024), while the EQoL-Index, calf perimeter, and levels of moderate-to-vigorous physical activity were identified as protective factors (Odds ratios: 0.025, 0.929, and 0.973, respectively).
    UNASSIGNED: This study highlights the complex relationship between non-modifiable factors such as age, and modifiable factors including quality of life, nutritional status, and physical activity in the development of cognitive frailty among older adults with a frailty phenotype living in the community.
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  • 文章类型: Journal Article
    这项研究旨在确定哪个社交网络,人口统计学,和健康指标变量能够预测中年及以后加拿大成年人高营养风险的发展,使用加拿大老龄化纵向研究的数据。多变量二项logistic回归用于检查随访时高营养风险发展的预测因素,基线后3年。在基线,35.0%的参与者处于高营养风险,42.2%的参与者在随访中处于高风险。社会支持水平较低,社会参与度较低,抑郁症,自我评估的健康老龄化与随访时高营养风险的发展有关。显示这些因素的个体应积极筛查营养风险。
    This study aimed to determine which social network, demographic, and health-indicator variables were able to predict the development of high nutrition risk in Canadian adults at midlife and beyond, using data from the Canadian Longitudinal Study on Aging. Multivariable binomial logistic regression was used to examine the predictors of the development of high nutrition risk at follow-up, 3 years after baseline. At baseline, 35.0 per cent of participants were at high nutrition risk and 42.2 per cent were at high risk at follow-up. Lower levels of social support, lower social participation, depression, and poor self-rated healthy aging were associated with the development of high nutrition risk at follow-up. Individuals showing these factors should be screened proactively for nutrition risk.
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  • 文章类型: Journal Article
    目的:营养不良是一种常见的老年综合征,具有包括死亡率在内的多种阴性结局。然而,很少有文献关注营养不良风险及其对老年综合征和癌症患者死亡率的临床意义之间的关系.这项研究的目的是确定营养不良风险在老年肿瘤学实践中的临床重要性。
    方法:180例≥65岁的癌症患者纳入研究。所有患者都接受了老年综合征的询问,包括多药房,脆弱,可能的肌少症,跌倒风险,强直症,抑郁症,认知障碍,失眠,和白天过度嗜睡。迷你营养评估评分>23.5和17-23.5分为营养良好和营养不良风险。分别。
    结果:在180名患者中(平均年龄73.0±5.6岁,女性:50%),营养不良风险的患病率为28.9%.各组之间在年龄方面没有统计学上的显著差异,性别,教育,婚姻状况,身体质量指数,除慢性阻塞性肺疾病外的合并症(p>0.05)。调整后的年龄,性别,和体重指数;多重用药(比值比[OR]:3.17;95%置信区间[CI],1.48-6.81),小腿围减少(OR:3.72;95%CI,1.22-11.38),跌倒风险(OR:2.72;95%CI,1.03-7.23),抑郁症(OR:6.24;95%CI,2.75-14.18),失眠(OR:4.89;95%CI,2.16-11.05),与营养良好的患者相比,虚弱(OR:2.44;95%CI,1.75-3.40)与营养不良风险相关(p<0.05)。营养不良风险患者的中位生存期为21.3个月(范围14.1-28.495%CI),未达到营养良好的患者的中位生存期(p<0.001)。
    结论:在老年癌症患者中,营养不良的风险与全因死亡的风险更高相关,并与许多老年综合征有关,包括多药房,跌倒风险,脆弱,失眠,和抑郁症。
    OBJECTIVE: Malnutrition is a common geriatric syndrome with multiple negative outcomes including mortality. However, there is a scarcity of literature that focuses on the relationship between malnutrition risk and its clinical implications on geriatric syndromes and mortality among cancer patients. The aim of this study is to determine the clinical importance of malnutrition risk in geriatric oncology practice.
    METHODS: 180 patients with cancer who were ≥ 65 years were included in the study. All patients were questioned in terms of geriatric syndromes, including polypharmacy, frailty, probable sarcopenia, fall risk, dynapenia, depression, cognitive impairment, insomnia, and excessive daytime sleepiness. Mini Nutritional Assessment scores > 23.5 and 17-23.5 were categorized as well-nourished and malnutrition risk, respectively.
    RESULTS: Of the 180 patients (mean age 73.0 ± 5.6 years, female: 50%), the prevalence of malnutrition risk was 28.9%. There was no statistically significant difference between the groups in terms of age, gender, education, marital status, body mass index, and comorbidities except for chronic obstructive pulmonary disease (p > 0.05). After adjustment for age, sex, and body mass index; polypharmacy (odds ratio [OR]: 3.17; 95% confidence interval [CI], 1.48-6.81), reduced calf circumference (OR: 3.72; 95% CI, 1.22-11.38), fall risk (OR: 2.72; 95% CI, 1.03-7.23), depression (OR: 6.24; 95% CI, 2.75-14.18), insomnia (OR: 4.89; 95% CI, 2.16-11.05), and frailty (OR: 2.44; 95% CI, 1.75-3.40) were associated with malnutrition risk compared to well-nourished patients (p < 0.05). Median survival in patients with malnutrition risk was 21.3 months (range 14.1-28.4 95% CI) and median survival in patients who were defined as well nourished was not reached (p < 0.001).
    CONCLUSIONS: The risk of malnutrition was associated with a higher risk for all-cause mortality in older patients with cancer, and was associated with many geriatric syndromes, including polypharmacy, fall risk, frailty, insomnia, and depression.
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