majocchi’s granuloma

Majocchi 肉芽肿
  • 文章类型: Case Reports
    带状疱疹(HZ)感染是由水痘-带状疱疹病毒(VZV)的重新激活引起的,在浅表真菌感染部位很少有报道。此外,在深部真菌感染部位发生的HZ尚未在文献中报道。我们讨论了一例45岁男性患者的独特病例,该患者表现为伴有播散性HZ的Majocchi肉芽肿(MG)。
    Herpes zoster (HZ) infection is caused by the reactivation of the varicella-zoster virus (VZV) and has very rarely been reported at the site of a superficial fungal infection. Also, HZ occurring at the site of a deep fungal infection has not been reported in the literature. We discuss a unique case of a 45-year-old male patient presenting with a Majocchi granuloma (MG) superinfected with disseminated HZ.
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  • 文章类型: Journal Article
    肾移植是受鼓励的肾脏替代疗法,因为它可以提供更长时间的存活和更好的生活质量。不幸的是,由于长期使用免疫抑制,肾移植受者容易感染。尽管皮肤癣菌感染通常不会危及生命,最近,越来越多的免疫功能低下患者增强了临床意义。我们提出了一种罕见的皮肤癣菌病,Majocchi肉芽肿,在移植后早期传播到所有四肢。由于移植后早期的急性排斥反应,一名年轻的肾移植受者接受了强化的免疫抑制治疗。四个月后,身体各个部位出现了许多结节性皮肤病变。在皮肤活检中发现侵袭性真菌感染。此外,在组织培养物中分离出红色毛癣菌。因此,患者被诊断为Majocchi肉芽肿。口服特比萘芬片剂可获得有效的治疗。Majocchi肉芽肿是一种独特的皮肤癣菌病,其特征是感染扩散到真皮。在这种意想不到的情况下,我们提醒医生注意肾移植受者的机会性感染.
    Kidney transplantation is the encouraged kidney replacement therapy due to providing more prolonged survival with a better quality of life. Unfortunately, kidney transplant recipients are susceptible to infections because of long-term utilization of immunosuppression. Despite dermatophyte infections are generally not life-threatening, the clinical significance has been recently enhanced by an increasing number of immunocompromised patients. We have presented a rare dermatophytosis course, Majocchi\'s granuloma, that spreads to all extremities during the early post-transplant period. A young kidney transplant recipient was exposed to intensive immunosuppression therapy due to acute rejection in the early period of post-transplantation. After four months, numerous nodular skin lesions were raised on various body parts. An invasive fungal infection was identified in the skin biopsy. Also, Trichophyton rubrum was isolated in the tissue cultures. Consequently, the patient was diagnosed with Majocchi\'s granuloma. An effectual treatment was attained with an oral terbinafine tablet. Majocchi\'s granuloma is a distinct form of dermatophytosis characterized by the spreading of infection into the dermis. In this unexpected case, we alerted physicians to opportunistic infections in the kidney transplant recipient.
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  • 文章类型: Case Reports
    真菌感染的诊断可能很有挑战性,但是每个专业的医生都可能遇到这个问题。它们可能被误认为是其他常见的皮肤病,如湿疹或牛皮癣,无意中被外用皮质类固醇或钙调磷酸酶抑制剂治疗。这可能会导致隐姓埋名的癣,用于描述临床表现改变的真菌感染的术语,这可能会使临床医生更加困惑。该病例报告介绍了一名54岁的先前健康的男性,其生殖器腹股沟区域有4个月的疼痛和瘙痒性皮疹史。患者的全科医生尝试用局部特比萘芬治疗皮疹失败,益康唑-曲安奈德,和倍他米松夫西地酸,除了口服双氯西林胶囊。在检查中,大腿和耻骨区域有多个红蓝结节和脓疱合并成浸润性红斑。真菌培养是阴性的,但是,临床特征以及长期使用局部类固醇和抗真菌药物的历史引起了对深部真菌感染的怀疑。组织病理学皮肤检查显示深部化脓性和肉芽肿性毛囊炎伴毛囊破裂,这与Majocchi肉芽肿的诊断一致。伊曲康唑胶囊治疗开始,经过16周的全身抗真菌治疗,皮疹解决了。总之,我们的病例报告显示了一例Majocchi肉芽肿,这是一个很棒的模仿者,特别是对于非皮肤科医生。因此,重要的是将诊断视为鉴别诊断,即使患者以前接受过局部抗真菌药物治疗。
    Fungal infections can be challenging to diagnose, but doctors of every specialty may encounter this issue. They can be mistaken for other common dermatoses such as eczema or psoriasis and inadvertently be treated with topical corticosteroids or calcineurin inhibitors. This may lead to tinea incognita, a term used to describe a fungal infection with an altered clinical appearance, which may confuse the clinician even further. This case report presents a 54-year-old previously healthy man with a 4-month history of a painful and pruritic rash in the genitoinguinal region. The patient\'s general practitioner had unsuccessfully attempted to treat the rash with topical terbinafine, econazole-triamcinolone, and betamethasone-fusidic acid, in addition to peroral dicloxacillin capsules. On examination, there were multiple red-bluish nodules and pustules coalescing into infiltrating erythematous plaques on both thighs and in the pubic region. Fungal cultures were negative, but the clinical features together with the history of prolonged use of combined topical steroids and antifungals raised suspicion of a deep fungal infection. Histopathological skin examination revealed deep suppurative and granulomatous folliculitis with ruptured hair follicles which was consistent with a diagnosis of Majocchi\'s granuloma. Treatment with itraconazole capsules was initiated, and after a 16-week course of systemic antifungal therapy, the rash resolved. In conclusion, our case report presents a case of Majocchi\'s granuloma, which is a great mimicker, especially for non-dermatologists. It is therefore important that the diagnosis is considered as a differential diagnosis, even though a patient has previously been treated with a topical antifungal.
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  • 文章类型: Journal Article
    Majocchi肉芽肿(MG)是一种罕见的深部真菌性毛囊炎,最常见的是由皮肤癣菌引起。这里,我们介绍一例面部MG。
    Majocchi\'s granuloma (MG) is an uncommon form of deep fungal folliculitis that is most frequently caused by dermatophytes. Here, we present a case of facial MG.
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  • 文章类型: Journal Article
    目的:炎性癣是一种罕见的皮肤癣菌,主要引起皮肤和头发的真菌感染。这篇综述旨在介绍有关其流行病学的所有现有证据,病因,临床特征,和诊断方法以及各种炎症性癣感染推荐的治疗方法。本文对Majocchi肉芽肿和皮肤癣菌或Hadida病进行了综述。
    结果:皮肤癣菌的新系统发育分类包括9个属,影响人类的是毛癣菌,小孢子菌,表皮胚乳,还有Nannizzia.此外,分子的进步揭示了由炎性癣引起的抗真菌免疫反应受损,这些都在这篇文章中详细介绍。
    结论:这些病理的共同点是存在受损的免疫反应,因此,宿主的炎症反应受损。为了使用适当的诊断方法并提供适当的治疗,必须熟悉这些免疫学特征。
    OBJECTIVE: Inflammatory tinea is an uncommon group of dermatophyte entities that predominantly cause fungal infection of the skin and hair. This review intends to present all of the available evidence regarding its epidemiology, etiopathogenesis, clinical features, and diagnostic methods as well as treatments recommended for various inflammatory tinea infections. This article provides a review of Majocchi\'s granuloma and dermatophytic or Hadida\'s disease.
    RESULTS: The new phylogenetic classification of dermatophytes includes nine genera, and those that affect humans are Trichophyton, Microsporum, Epidermophyton, and Nannizzia. Furthermore, molecular advancements have revealed impaired antifungal immune responses caused by inflammatory tinea, which are detailed in this article.
    CONCLUSIONS: The common denominator in these pathologies is the presence of impaired immune responses and, consequently, an impaired inflammatory response by the host. It is necessary to be familiar with these immunological characteristics in order to use the appropriate diagnostic methods and to provide adequate treatment.
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  • 文章类型: Case Reports
    Majocchi\'s granuloma is an uncommon fungal infection of the dermis and subcutaneous tissue. The most frequently identified cause of Majocchi\'s granuloma is anthropophilic Trichophyton rubrum, and it is most commonly located on the anterior aspect of the lower limbs in women. Here, we report a case of Majocchi\'s granuloma on the forearm, a site that is rarely involved, in a 62-year-old woman who had been bitten by a dog. Histological examination revealed a dense dermal infiltrate composed of lymphoplasmacytic cells and neutrophils, with hyphae in the dermis. The presence of the fungus, Trichophyton tonsurans, was confirmed by mycological examination and molecular methods. Therefore, histological and mycological examination confirmed the diagnosis of Majocchi\'s granuloma. The patient was treated with local moxibustion and itraconazole, 200 mg/day, for 60 days, which facilitated a complete resolution of the lesions.
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  • 文章类型: Case Reports
    Dermatophytic granuloma, also called Majocchi\'s granuloma (MG), is an uncommon infection of the dermis and subcutaneous tissues that can occur in both healthy and immunosuppressed hosts. We present two cases of MG with different clinical features. Both patients had satisfactory relief after treatment with terbinafine.
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  • 文章类型: Case Reports
    Majocchi\'s granuloma is an intracutaneous or subcutaneous granulomatous inflammation caused by invasion of dermatophytic fungus, especially Trichophyton rubrum. This type of lesion is misdiagnosed frequently without proper auxiliary examination. Here, we report a case of widespread Majocchi\'s granuloma caused by T. rubrum in a 35-year-old woman with systemic lupus erythematosus for 9 years. The patient was initially misdiagnosed as SLE-associated skin lesions, which delayed her treatment and resulted in severe multiple disseminated lesions. After confirmed as Majocchi\'s granuloma, the patient was cured after 11-month treatment with terbinafine.
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