癌症是一个全球性问题,因此正在做出各种努力。氧化铁被认为是生物医学领域中用于癌症治疗的重要生化试剂。海洋大型藻类介导的氧化铁,尤其是,磁铁矿(Fe3O4)纳米颗粒(NPs)由于其荧光和磁性而成为诊断和治疗癌症的潜在替代品。我们打算评估罗森维因的水提取物的可用性(R.intricata)在Fe3O4NP合成中,并研究其对人肝癌(Hep3B)和胰腺(PANC1)癌细胞的细胞毒性作用。在本研究中,R.intricata是从南安达曼沿海地区收集的,印度。利用R.intricata的水提物通过共沉淀法合成Fe3O4NP。从紫外可见漫反射光谱分析中,植物合成的Fe3O4NPs在400-600nm处显示出宽峰,验证了NPs的形成。荧光光谱中660nm处的能带边缘发射峰证实了Fe3O4NP中的量子限制。傅里叶变换红外光谱证实了R.intricata作为具有O-H等官能团的封端和还原剂的作用,C-H,C=O,N=O,C=C,C-O,C-N,和由氨基酸产生的C-S,多糖,脂肪烃,酯类,酰胺,木质素,烷烃,脂肪胺,和硫酸盐.物理化学性质,如微晶尺寸(14.36nm),流体动力学尺寸(84.6nm),不规则形态,元素组成,粒径(125nm),结晶度和饱和磁化强度(0.90007emu/g)由X射线衍射仪获得,动态光散射,扫描电子显微镜,能量色散X射线光谱仪,高分辨率透射电子显微镜,选定区域电子衍射和振动样品磁强计技术,分别。细胞活力显示出剂量依赖性的细胞毒性作用,并增强了针对Hep3B和PANC1癌细胞的凋亡。R.intricata提取物覆盖的Fe3O4NPs可能是用于癌症治疗和管理的最合适和有效的纳米材料。
Cancer is a global issue and hence various efforts are being made. Iron oxide is considered a significant biochemical agent in the biomedical arena for cancer treatment. Marine macroalgae-mediated iron oxides especially,
magnetite (Fe3O4) nanoparticles (NPs) are a prospective alternative to diagnose and treat cancer owing to their fluorescent and magnetic properties. We intend to appraise the usability of the aqueous extract of Rosenvingea intricata (R. intricata) in Fe3O4 NPs synthesis and to study their cytotoxic effects against human hepatocarcinoma (Hep3B) and pancreatic (PANC1) cancer cells. In the present study, R. intricata were collected from the coastal region of South Andaman, India. Aqueous extracts of R. intricata were utilized to synthesize Fe3O4 NPs via the co-precipitation method. Phycosynthesized Fe3O4 NPs exhibited wide peak at 400-600 nm from ultraviolet-visible diffused reflectance spectroscopic analysis which validated the formation of NPs. Band edge emission peak at 660 nm in fluorescent spectra confirmed the quantum confinement in Fe3O4 NPs. Fourier transform infrared spectroscopy confirmed the role of R. intricata as a capping and reducing agent with functional groups such as O-H, C-H, C=O, N=O, C=C, C-O, C-N, and C-S arising from amino acids, polysaccharides, aliphatic hydrocarbons, esters, amides, lignins, alkanes, aliphatic amines, and sulfates. Physicochemical properties such as crystallite size (14.36 nm), hydrodynamic size (84.6 nm), irregular morphology, elemental composition, particle size (125 nm), crystallinity, and saturation magnetization (0.90007 emu/g) were obtained from x-ray diffractometer, dynamic light scattering, scanning electron microscopy, energy dispersive x-ray spectrometer, high-resolution transmission electron microscopy, selected area electron diffraction and vibrating sample magnetometer techniques, respectively. The cell viability showed dose-dependent cytotoxic effects and enhanced the apoptosis against Hep3B and PANC1 cancer cells. R. intricata extract capped Fe3O4 NPs could be the most appropriate and effective nanomaterial for cancer treatment and management.