癌症,一种致命的疾病,拥有多种治疗替代方案来对抗它的存在,金属配合物已经成为重要的药用化合物,表现出相当大的生物学功效,尤其是作为抗癌剂。顺铂在各种癌症类型治疗中的应用,包括乳腺癌,为设计用于乳腺癌治疗的新型纳米结构金属配合物提供了灵感。值得注意的是,创新的多官能醚配体(包含Mn(II),Ni(II),Cu(II),Zn(II),Hg(II),和Ag(I)离子)已合成。为了确定它们的结构特征,元素和光谱分析,包括IR,UV-Vis,1H-NMR,质量和电子自旋共振(ESR)光谱,磁矩,摩尔电导,热分析,和电子显微镜,被雇用。这些络合物在DMF中的摩尔电导证明了非电解性质。通过电子显微镜数据鉴定了复合物的纳米结构形式。在环境温度下,固体配合物的ESR光谱表现出各向异性和各向同性的变化,表明共价键合。对配体及其几种金属配合物进行了针对乳腺癌蛋白3S7S和肝癌蛋白4OO6的细胞毒性测试,其中Ag(I)配合物(7)显示出最有效的作用,其次是Cu(II)与配体(配合物(2)),顺铂,配体本身,和Cu(II)/Zn(II)配合物(8)。分子对接数据揭示了几种复合物的抑制顺序。
Cancer, a lethal ailment, possesses a multitude of therapeutic alternatives to combat its presence, metal complexes have emerged as significant classes of medicinal compounds, exhibiting considerable biological efficacy, especially as anticancer agents. The utilization of cis-platin in the treatment of various cancer types, including breast cancer, has served as inspiration to devise novel nanostructured metal complexes for breast cancer therapy. Notably, homo- and hetero-octahedral bimetallic complexes of an innovative multifunctional ether ligand (comprising Mn(II), Ni(II), Cu(II), Zn(II), Hg(II), and Ag(I) ions) have been synthesized. To ascertain their structural characteristics, elemental and spectral analyses, encompassing IR, UV-Vis, 1H-NMR, mass and electron spin resonance (ESR) spectra, magnetic moments, molar conductance, thermal analysis, and electron microscopy, were employed. The molar conductance of these complexes in DMF demonstrated a non-electrolytic nature. Nanostructured forms of the complexes were identified through electron microscopic data. At ambient temperature, the ESR spectra of the solid complexes exhibited anisotropic and isotropic variants, indicative of covalent bonding. The ligand and several of its metal complexes were subjected to cytotoxicity testing against breast cancer protein 3S7S and liver cancer protein 4OO6, with the Ag(I) complex (7) evincing the most potent effect, followed by the Cu(II) with ligand (complex (2)), Cis-platin, the ligand itself, and the Cu(II)/Zn(II) complex (8). Molecular docking data unveiled the inhibitory order of several complexes.