本文通过比较从MRSI获得的神经肿瘤标志物与MRF的T1/T2图,研究了神经胶质瘤患者的磁共振波谱成像(MRSI)和磁共振指纹(MRF)之间的相关性。通过定义T1,T2和各种代谢比的热点来分析来自12名同意的神经胶质瘤患者的数据。并使用Sørensen-Dice相似系数(DSC)和它们的强度中心(COID)之间的距离进行比较。MRF和肿瘤分割之间的DSC中位数为0.73(T1)和0.79(T2)。MRSI和MRF之间的DSC对Gln/tNAA最高(T1:0.75,T2:0.80,肿瘤:0.78),其次是Gly/tNAA(T1:0.57,T2:0.62,肿瘤:0.54)和tCho/tNAA(T1:0.61,T2:0.58,肿瘤:0.45)。肿瘤热点的中值为T1=1724ms,T2=86ms,Gln/tNAA=0.61,Gly/tNAA=0.28,Ins/tNAA=1.15,tCho/tNAA=0.48,在瘤周区域,T1=1756ms,T2=102ms,Gln/tNAA=0.38,Gly/tNAA=0.20,Ins/tNAA=1.06,tCho/tNAA=0.38,在NAWM中,T1=950ms,T2=43ms,Gln/tNAA=0.16,Gly/tNAA=0.07,Ins/tNAA=0.54,tCho/tNAA=0.20。本研究的结果构成了7TMRSI和3TMRF的首次比较,显示了这些方法之间的良好对应关系。
This paper investigated the correlation between magnetic resonance spectroscopic imaging (MRSI) and magnetic resonance fingerprinting (MRF) in glioma patients by comparing neuro-oncological markers obtained from MRSI to T1/T2 maps from MRF. Data from 12 consenting patients with gliomas were analyzed by defining hotspots for T1, T2, and various metabolic ratios, and comparing them using Sørensen-Dice similarity coefficients (DSCs) and the distances between their centers of intensity (COIDs). The median DSCs between MRF and the tumor segmentation were 0.73 (T1) and 0.79 (T2). The DSCs between MRSI and MRF were the highest for Gln/tNAA (T1: 0.75, T2: 0.80, tumor: 0.78), followed by Gly/tNAA (T1: 0.57, T2: 0.62, tumor: 0.54) and tCho/tNAA (T1: 0.61, T2: 0.58, tumor: 0.45). The median values in the tumor hotspot were T1 = 1724 ms, T2 = 86 ms, Gln/tNAA = 0.61, Gly/tNAA = 0.28, Ins/tNAA = 1.15, and tCho/tNAA = 0.48, and, in the peritumoral region, were T1 = 1756 ms, T2 = 102 ms, Gln/tNAA = 0.38, Gly/tNAA = 0.20, Ins/tNAA = 1.06, and tCho/tNAA = 0.38, and, in the NAWM, were T1 = 950 ms, T2 = 43 ms, Gln/tNAA = 0.16, Gly/tNAA = 0.07, Ins/tNAA = 0.54, and tCho/tNAA = 0.20. The results of this study constitute the first comparison of 7T MRSI and 3T MRF, showing a good correspondence between these methods.