■睡眠增强了对疫苗接种的抗体反应,但是睡眠与严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的mRNA疫苗接种之间的关系尚未完全了解。
■在这项前瞻性观察研究中,我们调查了睡眠习惯对48名健康成年人中SARS-CoV-2mRNA疫苗诱导的免疫获得的影响(BNT-162b2,n=34;mRNA-1273,n=14;女性,n=30,62.5%;男性,n=18,37.5%;中位年龄,39.5年;四分位数范围,33.0-44.0年)从2021年6月到2022年1月。该研究使用肌动描记术和睡眠日记测量睡眠持续时间,涵盖了初次和加强疫苗接种的时期。
■多变量线性回归分析表明,加强疫苗接种后3天和7天的体动测定客观睡眠持续时间与较高的抗体滴度独立且显着相关(B=0.003;95%置信区间,0.000-0.005;Beta=0.337;p=0.02),即使在控制了协变量之后,包括年龄,性别,疫苗的类型,和对疫苗接种的反应原性。疫苗接种前获得抗体滴度与平均客观睡眠时间之间的关联,并且通过睡眠日记测量的任何主观睡眠持续时间都可以忽略不计。
■更长的目标,但不是主观的,加强疫苗接种后的睡眠持续时间增强了抗体反应。因此,鼓励公民在mRNA疫苗接种后睡眠时间更长,尤其是在加强剂量后,可能会增加对SARS-CoV-2的保护。
■本研究在大学医院医疗信息网络中心注册(UMIN:https://www.乌明。AC.jp)2021年7月30日,#UMIN000045009。
Sleep enhances the antibody response to vaccination, but the relationship between sleep and mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not fully understood.
In this prospective observational study, we investigated the influence of sleep habits on immune acquisition induced by mRNA vaccines against SARS-CoV-2 in 48 healthy adults (BNT-162b2, n=34; mRNA-1273, n=14; female, n=30, 62.5%; male, n=18, 37.5%; median age, 39.5 years; interquartile range, 33.0-44.0 years) from June 2021 to January 2022. The study measured sleep duration using actigraphy and sleep diaries, which covered the periods of the initial and booster vaccinations.
Multivariable linear regression analysis showed that actigraphy-measured objective sleep duration 3 and 7 days after the booster vaccination was independently and significantly correlated with higher antibody titers (B=0.003; 95% confidence interval, 0.000-0.005; Beta=0.337; p=0.02), even after controlling for covariates, including age, sex, the type of vaccine, and reactogenicity to the vaccination. Associations between acquired antibody titer and average objective sleep duration before vaccination, and any period of subjective sleep duration measured by sleep diary were negligible.
Longer objective, but not subjective, sleep duration after booster vaccination enhances antibody response. Hence, encouraging citizens to sleep longer after mRNA vaccination, especially after a booster dose, may increase protection against SARS-CoV-2.
This study is registered at the University Hospital Medical Information Network Center (UMIN: https://www.umin.ac.jp) on July 30, 2021, #UMIN000045009.