未经证实:下肢动脉硬化闭塞症(LEASO)患者更有可能与不良心血管结局相关。目前,很少有研究报道LEASO患者的性别特异性特征和主要心脑血管不良事件(MACCEs)风险.我们的研究是为了确定LEASO对男性和女性MACCE的特征和贡献。
UNASSIGNED:我们于2017年11月至2019年11月在武汉大学人民医院进行了一项单中心回顾性研究。LEASO组和对照组之间的患者比例为1:1,基于年龄,性别,糖尿病和高血压合并症,目前吸烟和药物。MACCE的发生被用作这项观察性研究的主要终点。
未经授权:本研究纳入了LEASO组(n=430)和对照组(n=430)。在平均38.83±14.28个月的随访中,共有183例患者经历了MACCE。多因素Cox回归分析显示LEASO是所有患者MACCEs发生的独立预测因子(HR:2.448,95%CI:1.730~3.464,P<0.001)。按性别亚组进行性别亚组分析,LEASO也是男性病例(HR:2.919,95%CI:1.776-4.797,P<0.001)和女性病例(HR:1.788,95%CI:1.110-2.880,P=0.017)发生MACCE的独立预测因子。此外,Kaplan-Meier分析显示,不同性别LEASO患者的无事件生存率差异无统计学意义(χ2=0.742,P=0.389)。
UNASSIGNED:在我们的研究中,LEASO倾向于作为男性和女性患者MACCEs的有用风险分层指标。值得注意的是,应注意接受全面心血管评估和干预的LEASO患者,即使缺乏传统的心血管危险因素。
UNASSIGNED: Patients with lower extremity arteriosclerosis obliterans (LEASO) are more likely to appear to be associated with adverse cardiovascular outcomes. Currently, few studies have reported the sex-specific characteristics and risk of major cardiovascular and cerebrovascular adverse events (MACCEs) in LEASO. Our study was conducted to determine the characteristics and contributions of LEASO to MACCEs in males and females.
UNASSIGNED: We conducted a single-center retrospective study of consecutively enrolled patients with first-diagnosed LEASO at Renmin Hospital of Wuhan University from November 2017 to November 2019. The ratio of patients between the LEASO and control groups was 1 to 1 and based on age, sex, comorbid diabetes mellitus and hypertension, current smoking and medications. The occurrence of MACCEs was used as the primary endpoint of this observational study.
UNASSIGNED: A LEASO group (n = 430) and control group (n = 430) were enrolled in this study. A total of 183 patients experienced MACCEs during an average of 38.83 ± 14.28 months of follow-up. Multivariate Cox regression analysis indicated that LEASO was an independent predictor of the occurrence of MACCEs in all patients (HR: 2.448, 95% CI: 1.730-3.464, P < 0.001). Subgroup analysis by sex subgroup was conducted for sex, and LEASO was also an independent predictor of the occurrence of MACCEs in both male cases (HR: 2.919, 95% CI: 1.776-4.797, P < 0.001) and female cases (HR: 1.788, 95% CI: 1.110-2.880, P = 0.017). Moreover, Kaplan-Meier analysis indicated no significant difference in event-free survival between patients of different sexes with LEASO (χ2 = 0.742, P = 0.389).
UNASSIGNED: LEASO tended to a useful risk stratified indicator for MACCEs in both male and female patients in our study. Notably, attention should be given to patients with LEASO who should undergo comprehensive cardiovascular evaluation and intervention, even if there is a lack of traditional cardiovascular risk factors.