乳糜泻(CeD)是一种慢性自身免疫性疾病,由遗传易感个体的谷蛋白引发,以CeD特异性抗体为特征,HLA-DQ2和/或HLA-DQ8单倍型,肠病和不同的临床图片涉及许多器官。肠淋巴瘤可能是难治性CeD的结果。如果诊断为CeD的患者有症状,尽管严格的无麸质饮食至少12个月,严重绒毛萎缩并没有改善,可以认为存在耐火CeD。两种难治性CeD中的第二种具有异常的单克隆上皮内淋巴细胞,可以认为是前淋巴瘤,接下来会出现的是与肠病相关的T细胞淋巴瘤。本手稿通过对当前文献和指南的回顾来解决“CeD和恶性肿瘤”。
Celiac disease (CeD) is a chronic autoimmune disorder that is triggered by gluten in genetically susceptible individuals, and that is characterized by CeD-specific antibodies, HLA-DQ2 and/or HLA-DQ8 haplotypes, enteropathy and different clinical pictures related to many organs. Intestinal lymphoma may develop as a result of refractory CeD. If a patient diagnosed with CeD is symptomatic despite a strict gluten-free diet for at least 12 months, and does not improve with severe villous atrophy, refractory CeD can be considered present. The second of the two types of refractory CeD has abnormal monoclonal intraepithelial lymphocytes and can be considered as pre-lymphoma, and the next picture that will emerge is enteropathy-associated T-cell lymphoma. This manuscript addresses \"CeD and malignancies\" through a review of current literature and guidelines.