非酒精性脂肪性肝病(NAFLD)是目前全球范围内影响所有年龄和种族的最常见的肝病形式,即使在年轻人中也已成为持续的威胁。我们的目的是通过肝脏超声检查(LUS)评估低血糖指数地中海饮食(LGIMD)对NAFLD评分的影响。
EPAtologia中的NUTRIzione(NUTRIEPA)是一种基于人群的双盲RCT。数据收集于2011年,并在2013-14年进行了分析。
98名来自Putignano(Puglia,意大利南部)来自先前的基于人群的随机抽样研究,并确定为患有中度或重度NAFLD。
干预策略是分配LGIMD或对照饮食。
主要结局指标是NAFLD评分,由LUS定义。
随机化后,50名受试者被分配到LGIMD,48名受试者被分配到对照饮食。该研究持续了六个月,所有参与者都接受了每月的控制/检查。通过地中海适足指数(MAI)衡量,对LGIMD的依从性中位数为10.1。观察到时间与LGIMD对NAFLD评分的负交互作用(-4.14,95%CI-6.78,-1.49),并在第六个月变得更加明显(-4.43,95CI-7.15,-1.71)。LGIMD之间相互作用的积极影响,还观察到时间和年龄(第三个月:0.07,95%CI0.02,0.12;第六个月:0.08,95%CI0.03,0.13)。
发现LGIMD在相对较短的时间内降低NAFLD评分。鼓励那些不寻求医疗护理但仍患有NAFLD的受试者遵循LGIMD和其他生活方式干预措施,可以降低疾病的严重程度。这种饮食干预,也可以形成2型糖尿病(T2DM)和心血管疾病一级预防的基石。
Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS).
NUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14.
98 men and women coming from Putignano (Puglia, Southern Italy) were drawn from a previous randomly sampled population-based study and identified as having moderate or severe NAFLD.
The intervention strategy was the assignment of a LGIMD or a control diet.
The main outcome measure was NAFLD score, defined by LUS.
After randomization, 50 subjects were assigned to a LGIMD and 48 to a control diet. The study lasted six months and all participants were subject to monthly controls/checks. Adherence to the LGIMD as measured by Mediterranean Adequacy Index (MAI) showed a median of 10.1. A negative interaction between time and LGIMD on the NAFLD score (-4.14, 95% CI -6.78,-1.49) was observed, and became more evident at the sixth month (-4.43, 95%CI -7.15, -1.71). A positive effect of the interaction among LGIMD, time and age (Third month: 0.07, 95% CI 0.02, 0.12; Sixth month: 0.08, 95% CI 0.03,0.13) was also observed.
LGIMD was found to decrease the NAFLD score in a relatively short time. Encouraging those subjects who do not seek medical attention but still have NAFLD to follow a LGIMD and other life-style interventions, may reduce the degree of severity of the disease. Dietary intervention of this kind, could also form the cornerstone of primary prevention of Type 2 Diabetes Mellitus (T2DM) and cardiovascular disease.