Fall-related hip fractures are a serious public health issue in older adults. As most mechanistic hip fracture risk prediction models incorporate tissue tolerance, test methods that can accurately characterize the fracture force of the femur (and factors that influence it) are imperative. While bone possesses viscoelastic properties, experimental characterization of rate-dependencies has been inconsistent in the whole-femur literature. The goal of this study was to investigate the influence of experimental paradigm on loading rate and fracture force (both means and variability) during mechanical tests simulating lateral fall loadings on the proximal femur. Six pairs of matched femurs were split randomly between two test paradigms: a \'lower rate\' materials testing system (MTS) with a constant displacement rate of 60 mm/s, and a hip impact test system (HIT) comprised of a custom-built vertical drop tower utilizing an impact velocity of 4 m/s. The loading rate was 88-fold higher for the HIT (mean (SD) = 2465.49 (807.38) kN/s) compared to the MTS (27.78 (10.03) kN/s) paradigm. However, no difference in fracture force was observed between test paradigms (mean (SD) = 4096.4 (1272.6) N for HIT, and 3641.3 (1285.8) N for MTS). Within-paradigm variability was not significantly different across paradigms for either loading rate or fracture force (coefficients of variation ranging from 0.311 to 0.361). Within each test paradigm, significant positive relationships were observed between loading rate and fracture force (HIT adjusted R2 = 0.833, p = 0.007; MTS adjusted R2 = 0.983, p < 0.0001). Overall, this study provides evidence that energy-based impact simulators can be a valid method to measure femoral bone strength in the context of fall-related hip fractures. This study motivates future research to characterize potential non-linear relationships between loading rate and fracture threshold at both macro and microscales.

BACKGROUND: Flatfoot is a structural and functional deformity of the foot that might change ground reaction force variables of gait. Evaluating the components of ground reaction force in three dimensions during gait is considered clinically important. This study aimed to investigate the components of ground reaction force, impulse, and loading rate during gait in people with flexible and rigid flatfoot compared to healthy subjects. 20 young women with flatfoot in two experimental groups (10 with rigid flatfoot and 10 with flexible flatfoot) and 10 healthy women in the control group participated in this study. Ground reaction force components during gait were measured using two force plates. The peak of ground reaction forces, impulse, and loading rate were then extracted. Data were processed and analyzed using MATLAB and SPSS software. One-way ANOVA with a significant level (P˂0.05) was used for statistical analysis. The results showed that peak braking force was higher in the rigid flatfoot group than in the control group (p = 0.016) and the flexible flatfoot group (p = 0.003). The posterior force loading rate was significantly higher in the rigid flatfoot group than in the flexible flatfoot group (P = 0.04). There was no significant difference in vertical loading rate between groups (P˃0.05). Since the maximal posterior ground reaction force was higher in the subjects with rigid flatfoot than in those with flexible flatfoot and healthy subjects, the increase in posterior ground reaction force is associated with an increase in anterior shear force at the knee.

Understanding cellular force transmission dynamics is crucial in mechanobiology. We developed the DNA-based ForceChrono probe to measure force magnitude, duration, and loading rates at the single-molecule level within living cells. The ForceChrono probe circumvents the limitations of in vitro single-molecule force spectroscopy by enabling direct measurements within the dynamic cellular environment. Our findings reveal integrin force loading rates of 0.5-2 pN/s and durations ranging from tens of seconds in nascent adhesions to approximately 100 s in mature focal adhesions. The probe\'s robust and reversible design allows for continuous monitoring of these dynamic changes as cells undergo morphological transformations. Additionally, by analyzing how mutations, deletions, or pharmacological interventions affect these parameters, we can deduce the functional roles of specific proteins or domains in cellular mechanotransduction. The ForceChrono probe provides detailed insights into the dynamics of mechanical forces, advancing our understanding of cellular mechanics and the molecular mechanisms of mechanotransduction.

The cracking problem of asphalt concrete panels is a crucial consideration in the design of hydraulic asphalt concrete seepage control bodies. Panels experiencing uneven rises or falls of water levels during impoundment may exhibit loading rate effects. Investigating the fracture toughness value of asphalt concrete under varying loading rates is essential. This study employs a statistical method to calculate the fracture index KIC, using the semi-circular bending test (SCB) to examine the effect of loading rates on the Type I fracture mode of hydraulic asphalt concrete. The data are analyzed using the two-parameter Weibull distribution curve, offering insights into the minimum number of KIC test specimens. The results indicate an increase in KIC with loading rate, with greater data dispersion at faster rates. The Weibull distribution curve successfully fits the fracture behavior under different loading rates, providing valuable predictions. This study estimates the minimum number of SCB test specimens to be nine, based on a confidence level of 0.95 and a relative deviation not exceeding 5%.

BACKGROUND: Running exercise is an effective means to enhance cardiorespiratory fitness and body composition. Besides these health benefits, running is also associated with musculoskeletal injuries that can be more prevalent in individuals with excessive body weight. Little is known regarding the specific effects of overweight and foot pronation on ground reaction force distribution during running. Therefore, this study aimed to investigate the effects of overweight/obesity and foot pronation on running kinetics.
METHODS: Eighty-four young adults were allocated to four experimental groups: non-excessive body weight/non-pronated feet; non-excessive body weight/pronated feet; overweight or obesity/ non-pronated feet and overweight or obesity/pronated feet. Biomechanical testing included participants to run at ~ 3.2 m/s over an 18-m walkway with an embedded force plate at its midpoint. Three-dimensional ground reaction forces were recorded and normalized to body mass to evaluate running kinetics from 20 running trials. Test-re-test reliability for running speed data demonstrated ICC > 0.94 for each group and in total.
RESULTS: The results indicated significantly lower vertical impact peak forces (p = 0.001, effect size = 0.12), shorter time to reach the vertical impact peak (p = 0.006, effect size = 0.08) and reduced vertical loading rate (p = 0.0007, effect size = 0.13) in individuals with excessive body weight (overweight or obesity/non-pronated feet group and overweight or obesity/pronated feet) compared with individuals non-excessive body weight (non-excessive body weight/non-pronated feet and non-excessive body weight/pronated feet). Moreover, the excessive body weight groups presented lower peak braking (p = 0.01, effect size = 0.06) and propulsion forces (p = 0.003, effect size = 0.09), lower medio-lateral loading rate (p = 0.0009, effect size = 0.12), and greater free moments (p = 0.01, effect size = 0.07) when compared to the non-overweight groups. Moreover, a significant body mass by foot pronation interaction was found for peak medio-lateral loading rate. Non-excessive body weight/pronated feet, excessive body weight/non-pronated feet and excessive body weight/pronation groups presented lower medio-lateral loading rates compared to non-excessive body weight/non-pronated feet (p = 0.0001, effect size = 0.13).
CONCLUSIONS: Our results suggest that excessive body weight has an impact on ground reaction forces during running. We particularly noted an increase in medio-lateral and torsional forces during the stance phase. Individuals with excessive body weight appear to adapt their running patterns in an effort to attenuate early vertical impact loading.

[Purpose] To assess the reliability and validity of accelerometer-based impact absorption rate measurements during single-leg drop-jump landings. [Participants and Methods] Study participants were healthy adult males. The task involved a single-leg drop-jump from the platform with a forward landing onto a floor reaction force plate. Accelerometers were fastened to the trunk, while foot switches were attached to the forefoot plantar surfaces. The impact absorption rate was calculated as the peak composite acceleration during the single-leg drop-jump landing divided by the duration from foot contact to the attainment of peak value. The loading rate (LR) was calculated by dividing the peak vertical force by the duration from foot contact to the attainment of peak value, leveraging the data obtained from a floor reaction force plate. Intraclass correlation coefficients (ICC) were used for intra- and inter-rater reliability analyses of 18 and 12 participants, respectively. The validity was examined through the correlation between impact absorption rate and LR in the 18 participants. [Results] The intra- (ICC (1,1)) and inter-rater (ICC (2,1)) reliabilities for the impact absorption rates were 0.89 and 0.88, respectively. A significant positive correlation was observed between impact absorption rates and LR (r=0.71). [Conclusion] The impact absorption rate may be valuable in clinical practice.

The investigation of the behaviour of adhesive joints under high strain rates is an active area of research, primarily due to the widespread use of adhesives in various industries, including automotive manufacturing. Understanding how adhesives perform when subjected to high strain rates is crucial for designing vehicle structures. Additionally, it is particularly important to comprehend the behaviour of adhesive joints when exposed to elevated temperatures. Therefore, this study aims to analyse the impact of strain rate and temperature on the mixed-mode fracture characteristics of a polyurethane adhesive. To achieve this, mixed-mode bending tests were conducted on test specimens. These specimens were subjected to three different strain rates (0.2 mm/min, 200 mm/min, and 6000 mm/min) and tested at temperatures ranging from -30 °C to 60 °C. The crack size was measured using a compliance-based method during the tests. For temperatures above Tg, the maximum load supported by the specimen increased with an increasing loading rate. GI increased by a factor of 35 for an intermediate strain rate and 38 for a high strain rate from low temperature (-30 °C) to room temperature (23 °C). GII also increased for the same conditions by a factor of 25 and 95 times, respectively.

UNASSIGNED: Providing clinicians with an accurate method to predict kinetic measurements using 2D kinematic motion analysis is crucial to the management of distance runners. Evidence is needed to compare the accuracy of 2D and 3D kinematic measurements as well as measured and estimated kinetic variables.
UNASSIGNED: The objectives of this study were to (1) compare 2D video analysis of running kinematics with gold standard 3D motion capture and, (2) to evaluate published equations which estimate running kinetics using 2D kinematic and spatiotemporal values and modify these equations based on study findings.
UNASSIGNED: Controlled laboratory study, cross-sectional design.
UNASSIGNED: Runners who averaged at least 20 miles per week were invited to participate. Athletes ran on an instrumented treadmill at their preferred training pace for a 6-minute warm-up. Markers were placed over designated anatomical landmarks on both sides of the pelvis as well as the left lower extremity. Subjects then ran at their preferred speed and kinematic data were recorded using both the 2D and 3D camera systems at 240 frames/second. Additionally, ground reaction forces were recorded at 1200Hz. 2D and 3D kinematic values were compared and published kinetic prediction formulas were tested. Linear regression was used to develop new prediction equations for average loading rate (AVG_LR), peak vertical ground reaction force (VERT_GRF), and peak braking force (PK_BRK). Paired t-tests were used to assess differences between the 2D and 3D kinematic variables and the measured (MEAS) and calculated (CALC) kinetic variables.
UNASSIGNED: Thirty runners (13 men and 17 women) voluntarily consented to participate in this study and the mean age of the participants was 31.8 years (range 20 to 48 years). Although significant differences existed, all 2D kinematic measures were within 2°-5° of 3D kinematic measures. Published prediction equations for AVG_LR and VERT_GRF were supported, but new prediction equations showed higher R2 for AVG_LR (0.52) and VERT_GRF (0.75) compared to previous work. A new prediction equation for PK_BRK was developed. No significant differences were found between the MEAS and CALC kinetic variables using the new equations.
UNASSIGNED: Accurate predictions of kinetic variables can be made using spatiotemporal and 2D kinematic variables.
UNASSIGNED: Level 2.

The purpose of this study was to develop peak ground reaction force (pGRF) and peak loading rate (pLR) prediction equations for high-impact activities in adult subjects with a broad range of body masses, from normal weight to severe obesity. A total of 78 participants (27 males; 82.4 ± 20.6 kg) completed a series of trials involving jumps of different types and heights on force plates while wearing accelerometers at the ankle, lower back, and hip. Regression equations were developed to predict pGRF and pLR from accelerometry data. Leave-one-out cross-validation was used to calculate prediction accuracy and Bland-Altman plots. Body mass was a predictor in all models, along with peak acceleration in the pGRF models and peak acceleration rate in the pLR models. The equations to predict pGRF had a coefficient of determination (R2) of at least 0.83, and a mean absolute percentage error (MAPE) below 14.5%, while the R2 for the pLR prediction equations was at least 0.87 and the highest MAPE was 24.7%. Jumping pGRF can be accurately predicted through accelerometry data, enabling the continuous assessment of mechanical loading in clinical settings. The pLR prediction equations yielded a lower accuracy when compared to the pGRF equations.

Tensile deformation behavior of continuous high-strength and high-modulus single carbon fibers impregnated with a polysulfone solution was investigated. The effect of the carbon fiber type, mass fraction of the polymer, and the loading rate on the tensile strength was studied. It was observed that, whereas for high-modulus carbon fibers the magnitude of tensile strength depends significantly on the loading rate, for high-strength carbon fibers, such dependence was nearly not observed. SEM study shows that at low loading rates, elementary filaments inside the impregnated fiber are able to align themselves along the load application axis because a thermoplastic matrix can flow under the tensile stresses\' force. As a result, the fiber\'s strength properties can be realized more effectively in the thermoplastic-based composites than in the same composite with an epoxy matrix.