背景:由于手术过程中手术位置引起的压迫和下肢循环障碍,可能会发生井腿间室综合征(WLCS)。虽然罕见,在截石位进行的3500例手术中有1例发生,它会导致严重的并发症。因此,预防和早期诊断至关重要。WLCS的症状,如腿部疼痛,肿胀,感觉异常,和血清肌酸激酶(CK)水平对诊断有用。本研究旨在探讨腹腔镜或机器人辅助结直肠癌手术中术后CK升高的危险因素。
方法:在2022年2月至2023年3月期间,对178例接受腹腔镜或机器人辅助结直肠癌手术的患者进行了术后CK水平测量。我们比较了病人的背景,短期结果,CK水平≥250(n=62)和CK水平<250(n=116)的患者之间的大腿/小腿周长。我们使用单变量和多变量分析调查了CK水平升高的危险因素。
结果:4例CK水平为22405U/L的患者,4685U/L,4050U/L,和3824U/L报告的症状,经保守治疗改善。通过多变量分析确定了以下独立的预后因素:男性(优势比[OR],4.403;95%CI,1.960至9.892),直肠手术(或,2.779;95%CI,1.249至6.184),持续低头位置持续时间≥180分钟(或,3.523;95%CI,1.552至7.997),术前小腿围≥33cm(OR,2.482;95%CI,1.154至5.339)。
结论:截石位结直肠癌术后CK升高的危险因素包括男性,直肠手术,没有位置变化的延伸的连续低头位置,术前小腿围较大。这项研究强调了每3小时改变术中位置对防止CK水平升高的潜在重要性。尽管没有具体检查预防效果。
BACKGROUND: Well-leg compartment syndrome (WLCS) can occur due to compression and lower limb circulation disturbances caused by the surgical position during the procedure. Although rare, with an incidence of 1 in 3500 surgeries performed in the lithotomy position, it can lead to serious complications. Therefore, prevention and early diagnosis are critical. Symptoms of WLCS, such as leg pain, swelling, paresthesia, and serum creatine kinase (CK) levels are useful for diagnosis. This study aimed to investigate the risk factors for postoperative CK elevation in laparoscopic or robot-assisted colorectal cancer surgery performed in the lithotomy-Trendelenburg position.
METHODS: Postoperative CK levels were measured in 178 patients who underwent laparoscopic or robot-assisted colorectal cancer surgery between February 2022 and March 2023. We compared patient backgrounds, short-term outcomes, and thigh/calf circumferences between patients with CK levels ≥ 250 (n = 62) and those with CK levels < 250 (n = 116). We investigated risk factors for elevated CK levels using both univariate and multivariate analyses.
RESULTS: Four patients with CK levels of 22405 U/L, 4685 U/L, 4050 U/L, and 3824 U/L reported symptoms, which improved with conservative treatment. The following independent prognostic factors were identified by multivariate analysis: male sex (odds ratio [OR], 4.403; 95% CI, 1.960 to 9.892), rectal surgery (OR, 2.779; 95% CI, 1.249 to 6.184), continuous head-down position duration ≥ 180 min (OR, 3.523; 95% CI, 1.552 to 7.997), and preoperative calf circumference ≥ 33 cm (OR, 2.482; 95% CI, 1.154 to 5.339).
CONCLUSIONS: Risk factors for CK elevation after colorectal cancer surgery in the lithotomy position include male sex, rectal surgery, an extended continuous head-down position without position changes, and a larger preoperative calf circumference. This study highlights the potential importance of intraoperative position changes every 3 h for preventing elevated CK levels, although the preventive effect was not specifically examined.