背景:脂滴(LD)是一种代谢活跃的细胞器,随着细胞的代谢状态和能量需求而动态变化。插入LD磷脂单层或存在于细胞质中的蛋白质,在脂质稳态和信号调节中起关键作用,被称为LD相关蛋白。
方法:以关键词“脂滴”和“代谢性疾病”获取有关LD代谢和病理机制的文献。搜索包括Scopus在内的数据库后,OVID,WebofScience,从2013年到2024年,PubMed使用“脂滴”等术语,“脂滴相关蛋白”,“脂肪肝”,\"糖尿病\",“糖尿病肾病”,“肥胖”,“动脉粥样硬化”,“高脂血症”,“天然药物单体”和“天然化合物”,最常见的天然化合物在约954篇文章中被鉴定。最终,对10个天然化合物的体外或体内研究报告进行了共91项研究的改进和总结.
结果:最常用的天然化合物包括小檗碱,Mangostin,辣椒素,咖啡因,金雀异黄素,表没食子儿茶素-3-没食子酸酯,绿原酸,甜菜碱,人参皂苷,白藜芦醇。这些天然化合物与LD相关蛋白相互作用,有助于改善各种代谢疾病中的异常LD。
结论:参与调节LD和LD相关蛋白的天然化合物有望治疗代谢性疾病。对这些相互作用的进一步研究可能导致新的治疗应用。
BACKGROUND: Lipid droplet (LD) is a metabolically active organelle, which changes dynamically with the metabolic state and energy requirements of cells. Proteins that either insert into the LD phospholipid monolayer or are present in the cytoplasm, playing a crucial role in lipid homeostasis and signaling regulation, are known as LD-associated proteins.
METHODS: The keywords \"lipid droplets\" and \"metabolic diseases\" were used to obtain literature on LD metabolism and pathological mechanism. After searching databases including Scopus, OVID, Web of Science, and PubMed from 2013 to 2024 using terms like \"lipid droplets\", \"lipid droplet-associated proteins\", \"fatty liver disease\", \"diabetes\", \"diabetic kidney disease\", \"obesity\", \"atherosclerosis\", \"hyperlipidemia\", \"natural drug monomers\" and \"natural compounds\", the most common natural compounds were identified in about 954 articles. Eventually, a total of 91 studies of 10 natural compounds reporting in vitro or in vivo studies were refined and summarized.
RESULTS: The most frequently used natural compounds include Berberine, Mangostin, Capsaicin, Caffeine, Genistein, Epigallocatechin-3-gallate, Chlorogenic acid, Betaine, Ginsenoside, Resveratrol. These natural compounds interact with LD-associated proteins and help ameliorate abnormal LDs in various metabolic diseases.
CONCLUSIONS: Natural compounds involved in the regulation of LDs and LD-associated proteins hold promise for treating metabolic diseases. Further research into these interactions may lead to new therapeutic applications.