■全身免疫炎症指数(SII)是一种新型的综合性炎症标志物。炎症与肺功能受损有关。我们旨在探讨SII与肺功能之间的可能关系,以检查SII在预测肺功能下降方面的潜力。
■使用2007年至2012年NHANES的数据进行了横断面调查。采用多元线性回归模型分析SII与肺功能的线性关系。敏感性分析,亚组分析,和相互作用测试被用来检查不同人群之间这种关系的稳健性。拟合平滑曲线和阈值效应分析用于描述非线性关系。
■本研究共纳入10,125例患者。在调整所有协变量后,多元线性回归模型分析表明,高Log2-SII水平与FVC降低显著相关(β,-23.4061;95%CI,-42.2805-4.5317),FEV1(β,-46.7730;95%CI,-63.3371--30.2089),FEV1%(β,-0.7923;95%CI,-1.1635--0.4211),FEV1/FVC(β,-0.6366;95%CI,-0.8328--0.4404)和PEF(β,-121.4468;95%CI,-164.1939--78.6998)。在趋势检验和分层分析中,Log2-SII与肺功能指标之间的负相关保持稳定。Log2-SII与FVC倒U型关系,FEV1,FEV1%,和PEF被观察到,FEV1/FVC与Log2-SII呈负相关。Log2-SII与FVC之间非线性关系的截止值,FEV1,FEV1%,PEF分别为8.3736、8.0688、8.3745和8.5255。当SII超过临界值时,肺功能明显下降。
■这项研究发现SII与肺功能指标之间存在密切的相关性。这项研究调查了总体人群中肺功能开始下降时的SII阈值。SII可能成为预测肺功能下降的有希望的血清学指标。然而,需要进一步的前瞻性研究来确定这两个因素之间的因果关系。
UNASSIGNED: Systemic immune-inflammation index (SII) is a novel comprehensive inflammatory marker. Inflammation is associated with impaired lung function. We aimed to explore the possible relationship between SII and lung function to examine the potential of SII in predicting lung function decline.
UNASSIGNED: A cross-sectional survey was conducted using the data of the NHANES from 2007 to 2012. Multiple linear regression models were used to analyze the linear relationship between SII and pulmonary functions. Sensitivity analyses, subgroup analyses, and interaction tests were used to examine the robustness of this relationship across populations. Fitted smooth curves and threshold effect analysis were used to describe the nonlinear relationships.
UNASSIGNED: A total of 10,125 patients were included in this study. After adjusting for all covariates, multiple linear regression model analysis showed that high Log2-SII level was significantly associated with decreased FVC(β, -23.4061; 95% CI, -42.2805- -4.5317), FEV1(β, -46.7730; 95% CI, -63.3371- -30.2089), FEV1%(β, -0.7923; 95% CI, -1.1635- -0.4211), FEV1/FVC(β, -0.6366; 95% CI, -0.8328- -0.4404) and PEF(β, -121.4468; 95% CI,-164.1939- -78.6998). The negative correlation between Log2-SII and pulmonary function indexes remained stable in trend test and stratified analysis. Inverted U-shaped relationships between Log2-SII and FVC, FEV1, FEV1%, and PEF were observed, while a negative linear correlation existed between FEV1/FVC and Log2-SII. The cutoff values of the nonlinear relationship between Log2-SII and FVC, FEV1, FEV1%, PEF were 8.3736, 8.0688, 8.3745, and 8.5255, respectively. When SII exceeded the critical value, the lung function decreased significantly.
UNASSIGNED: This study found a close correlation between SII and pulmonary function indicators. This study investigated the SII threshold when lung functions began to decline in the overall population. SII may become a promising serological indicator for predicting lung function decline. However, prospective studies were needed further to establish the causal relationship between these two factors.