linear dermatosis

  • 文章类型: Journal Article
    纹状体地衣(LS),线性银屑病(LPs),线状皮肤红斑狼疮(LCLE)和线状扁平苔藓(LLP)常具有相似的临床表现,这使得肉眼难以进行临床诊断;因此,他们很容易被误诊。这项研究的目的是确定反射共聚焦显微镜(RCM)是否有助于区分儿童的这四种线性皮肤病。这项回顾性研究包括14例LS患者,九个有LP,八个与LCLE和12与LLP。所有患者均使用RCM进行分析,和活检是从先前通过RCM成像的病变中收集的。对于LS,真皮乳头状环部分缺失,但是当存在时,表现为小,均匀圆形,明亮的细胞和偶尔高度折射的丰满的细胞结构,在集群中聚合。LP表现出黑色的囊肿样结构,小,明亮,圆形细胞聚集在表皮水平;在真皮-表皮交界处,均匀分布,放大,在真皮浅层观察到微弱的真皮乳头状环和许多扩大的低屈光小管结构。LCLE和LLP表现出相似的表现,包括表皮紊乱,几乎完全没有真皮乳头状环,和各种大小的折射结构密集分布在真皮中。LCLE的主要区别特征是毛囊周围聚集的不同大小的结构,而LLP表现出分散分布的致密结构。RCM可用于区分LS的关键特征,LP,儿童LCLE和LLP。
    Lichen striatus (LS), linear psoriasis (LPs), linear cutaneous lupus erythematosus (LCLE) and linear lichen planus (LLP) often have similar clinical manifestations, which makes clinical diagnosis with the naked eye difficult; therefore, they are easily misdiagnosed. The purpose of this study was to determine whether reflectance confocal microscopy (RCM) is helpful in differentiating between these four linear dermatoses in children. This retrospective study included 14 patients with LS, nine with LPs, eight with LCLE and 12 with LLP. All patients were analysed using RCM, and biopsies were collected from lesions previously imaged by RCM. For LS, the dermal papillary rings were partially absent, but when present, manifested with small, homogeneously round, bright cells and occasionally highly refractive plump cellular structures, aggregated in clusters. LPs exhibited dark cyst-like structures with small, bright, round cells aggregated at the epidermal level; at the dermal-epidermal junction, homogeneously distributed, enlarged, faint dermal papillary rings and numerous enlarged low-refractive canalicular structures were observed in the superficial dermis. LCLE and LLP exhibited similar manifestations, including epidermal disarray, almost total absence of dermal papillary rings, and various sized refractive structures densely distributed in the dermis. The key distinguishing features of LCLE were the different sized structures mainly clustered around hair follicles, while LLP demonstrated dense structures with a scattered distribution. RCM may be used to distinguish between the key features of LS, LPs, LCLE and LLP in children.
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  • 文章类型: Journal Article
    在这项回顾性研究中,我们分析了30例扁平苔藓患者(年龄<18岁)的记录。70%为女性,30%为男性,诊断平均年龄为5.38±4.22岁。受影响的最常见年龄组为0-4岁。扁平苔藓的平均持续时间为6.66±4.22个月。9例(30%)患者存在特应性。虽然LS是一种良性的自限性皮肤病,对更多患者进行的长期前瞻性研究将有助于更好地了解该疾病,包括其病因和与特应性疾病的关系。
    We analyzed records of 30 patients with lichen striatus (age < 18 years) in this retrospective study. Seventy percent were females and 30% were males with a mean age of diagnosis of 5.38 ± 4.22 years. The most common age group affected was 0-4 years. The mean duration of lichen striatus was 6.66 ± 4.22 months. Atopy was present in 9 (30%) patients. Although LS is a benign self-limited dermatosis, long-term prospective studies with a greater number of patients will help in better understanding of the disease including its etiopathogenesis and association with atopy.
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  • 文章类型: Case Reports
    带状疱疹样扁平苔藓是皮肤扁平苔藓的一种变体,可能在带状疱疹治愈的部位发展,也可能自发进化,以前没有带状疱疹或水痘-带状疱疹病毒感染史。扁平苔藓是一种免疫介导的疾病,影响皮肤和粘膜。尽管如此,其确切病因尚不清楚。病变由多边形组成,瘙痒,平顶丘疹,可能合并形成斑块。这是一例39岁的女性,其躯干右侧有三个月的瘙痒性皮肤病变史。在皮肤病学检查中,有很大的,离散,带状,色素沉着过度,躯干和腹部右侧的Blaschko线条后出现丘疹。从病变处进行的活检的组织学检查显示,锯齿网脊,带状炎症浸润,确认诊断为扁平苔藓,并接受局部类固醇治疗。根据调查结果,一个刨床,遵循Blaschko线分布而不是皮球分布的瘙痒性皮疹应引起对带状疱疹样扁平苔藓的怀疑。
    Zosteriform lichen planus is a variant of cutaneous lichen planus that may develop at the site of healed herpes zoster or may evolve spontaneously with no previous history of herpes zoster or varicella-zoster virus infection. Lichen planus is an immune-mediated disorder that affects the skin and mucous membrane. Nonetheless, its exact etiology remains unclear. The lesion consists of polygonal, pruritic, flat-topped papules that may coalesce to form a plaque. This is a case of a 39-year-old female presenting with a three-month history of pruritic skin lesion over the right side of her trunk. On dermatological examination, there were large, discrete, band-like, hyperpigmented, papular patches following Blaschko\'s lines on the right side of the trunk and abdomen. The histological examination of a biopsy taken from the lesion showed hypergranulosis, sawtooth rete ridges, band-like inflammatory infiltrate, confirming the diagnosis of lichen planus and was treated with topical steroids. Based on the findings, a planer, pruritic skin rash that follows Blaschko\'s lines distribution rather than dermatomal distribution should raise the suspicion of zosteriform lichen planus.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    OBJECTIVE: Lichen striatus is a unilateral inflammatory dermatosis that rarely affects the nail unit. When the inflammation involves the nail unit, classic lichenoid nail changes are easily detectable, more often limited to only one portion of the nail. Usually the nail dystrophy coexists with periungual skin papules following Blaschko\'s lines, but it could also be an isolated feature. Because a nail unit biopsy presents difficulties in execution, especially in a child, the aim of our study has been to describe the nail unit dermoscopy features of lichen striatus hoping to provide a valid aid to clinicians in the diagnosing this rare disorder.
    METHODS: We reviewed the images of five pediatric patients with a clinical diagnosis of lichen striatus. Data about sex, age, localization, predisposing/triggering factors, and associated disorders are reported.
    RESULTS: The diagnosis of lichen striatus can be challenging as there are clinically overlapping features with related dermatoses. A common diagnostic pitfall occurs with inflammatory linear verrucous epidermal nevus and lichen planus. Involvement of only one part of the nail plate with linear longitudinal fissuring, ridging, and distal splitting, especially if seen with perionychial skin lesions, is characteristic of lichen striatus.
    CONCLUSIONS: Nail lichen striatus is rare, and there is sparse published literature on it. When the changes in lichen striatus are limited to the nail, the diagnosis may easily be missed. We therefore believe that dermoscopy is an important diagnostic maneuver, which should be integrated into the evaluation of patients with potential lichen striatus, and in particular is helpful for clinicians unwilling or unable to perform a nail unit biopsy.
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  • 文章类型: Case Reports
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  • 文章类型: Case Reports
    Linear atrophoderma of Moulin (LAM) is a rare dermatosis in childhood and early adolescence. The exact etiology of LAM is still obscure. Several treatment modalities were reported but none was consistently successful. We report a case of LAM in which a favorable outcome was obtained with topical calcipotriol. The relevant literature is also reviewed.
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