lichen striatus

纹状体苔藓
  • 文章类型: Journal Article
    头颅镜检查是一种有助于诊断指甲疾病的非侵入性方法。该研究的目的是回顾有关指甲镜在指甲牛皮癣中的可用性的文献,指甲扁平苔藓,和指甲地衣纹状体。
    指甲牛皮癣的前视特征是凹陷,伴有红斑性边界的指甲溶解症,鲑鱼片,碎片出血,外侧和近端褶皱中的点状血管,和下甲。指甲扁平苔藓的上颌骨特征是甲癣,甲状腺溶解症,纵向黑甲,和红色的Lunula.关于指甲镜在指甲扁平苔藓中的可用性的文献很少。
    与临床检查相比,腹腔镜检查有助于评估指甲异常。奇怪的改变,鲑鱼片,与裸眼相比,通过甲镜检查可以更好地观察指甲溶解的红斑边界以及指甲牛皮癣的碎片出血。头颅镜检查可增强对黑甲的检测,色素异常,和指甲扁平苔藓的肺脏变化。指甲和脚趾甲的特征不同。
    头颅镜检查(指甲皮肤镜检查)是一种用于诊断指甲疾病的非侵入性方法。在这次审查中,我们评估了胃镜检查是否有助于诊断炎性指甲疾病,如牛皮癣,扁平苔藓,和纹状体地衣.指甲牛皮癣的特征是存在点蚀,鲑鱼片,碎片出血,在胃镜检查下甲膜有或没有红斑边界和扩张血管的指甲溶解。甲扁平苔藓的上颌镜检查显示存在纵向起皱和裂开(甲癣),碎片出血,纵向黑甲以及红色的肺(指甲基质的远端)。指甲扁平苔藓的胃镜检查数据很少。甲镜检查是一个有用的工具,在可视化的指甲异常,与肉眼相比,大多数特征更好地可视化与onychoscopy。
    UNASSIGNED: Onychoscopy is a noninvasive method helpful in diagnosing nail disorders. The aim of the study was to review literature on the usability of onychoscopy in nail psoriasis, nail lichen planus, and nail lichen striatus.
    UNASSIGNED: Onychoscopic features of nail psoriasis are pitting, onycholysis with erythematous border, salmon patches, splinter hemorrhages, dotted vessels in lateral and proximal folds, and hyponychium. Onychoscopic features of nail lichen planus are onychorrhexis, onycholysis, longitudinal melanonychia, and red lunula. The literature on the usability of onychoscopy in nail lichen striatus is scarce.
    UNASSIGNED: Onychoscopy facilitates evaluation of nail abnormalities compared to the clinical examination. Lunular alterations, salmon patches, erythematous border of onycholysis as well as splinter hemorrhages in nail psoriasis are better visualized with onychoscopy compared to the naked eye. Onychoscopy enhances detection of melanonychia, dyschromia, and lunular changes in nail lichen planus. Onychoscopic features are different in fingernails and toenails.
    Onychoscopy (nail dermoscopy) is a noninvasive method used in diagnosing of nail disorders. In this review, we evaluated if onychoscopy may be helpful in diagnosing inflammatory nail disorders such as psoriasis, lichen planus, and lichen striatus. Nail psoriasis can be characterized with the presence of pitting, salmon patches, splinter hemorrhages, onycholysis with or without erythematous border and dilated vessels in the hyponychium on onychoscopy. Onychoscopy of nail lichen planus shows the presence of longitudinal ridging and splitting (onychorrhexis), splinter hemorrhages, longitudinal melanonychia as well as red lunula (distal part of nail matrix). The data on onychoscopy in nail lichen striatus are scarce. Onychoscopy is a helpful tool in visualization of nail abnormalities, with most of the features better visualized with onychoscopy compared to the naked eye.
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  • 文章类型: Journal Article
    纹状体地衣(LS),线性银屑病(LPs),线状皮肤红斑狼疮(LCLE)和线状扁平苔藓(LLP)常具有相似的临床表现,这使得肉眼难以进行临床诊断;因此,他们很容易被误诊。这项研究的目的是确定反射共聚焦显微镜(RCM)是否有助于区分儿童的这四种线性皮肤病。这项回顾性研究包括14例LS患者,九个有LP,八个与LCLE和12与LLP。所有患者均使用RCM进行分析,和活检是从先前通过RCM成像的病变中收集的。对于LS,真皮乳头状环部分缺失,但是当存在时,表现为小,均匀圆形,明亮的细胞和偶尔高度折射的丰满的细胞结构,在集群中聚合。LP表现出黑色的囊肿样结构,小,明亮,圆形细胞聚集在表皮水平;在真皮-表皮交界处,均匀分布,放大,在真皮浅层观察到微弱的真皮乳头状环和许多扩大的低屈光小管结构。LCLE和LLP表现出相似的表现,包括表皮紊乱,几乎完全没有真皮乳头状环,和各种大小的折射结构密集分布在真皮中。LCLE的主要区别特征是毛囊周围聚集的不同大小的结构,而LLP表现出分散分布的致密结构。RCM可用于区分LS的关键特征,LP,儿童LCLE和LLP。
    Lichen striatus (LS), linear psoriasis (LPs), linear cutaneous lupus erythematosus (LCLE) and linear lichen planus (LLP) often have similar clinical manifestations, which makes clinical diagnosis with the naked eye difficult; therefore, they are easily misdiagnosed. The purpose of this study was to determine whether reflectance confocal microscopy (RCM) is helpful in differentiating between these four linear dermatoses in children. This retrospective study included 14 patients with LS, nine with LPs, eight with LCLE and 12 with LLP. All patients were analysed using RCM, and biopsies were collected from lesions previously imaged by RCM. For LS, the dermal papillary rings were partially absent, but when present, manifested with small, homogeneously round, bright cells and occasionally highly refractive plump cellular structures, aggregated in clusters. LPs exhibited dark cyst-like structures with small, bright, round cells aggregated at the epidermal level; at the dermal-epidermal junction, homogeneously distributed, enlarged, faint dermal papillary rings and numerous enlarged low-refractive canalicular structures were observed in the superficial dermis. LCLE and LLP exhibited similar manifestations, including epidermal disarray, almost total absence of dermal papillary rings, and various sized refractive structures densely distributed in the dermis. The key distinguishing features of LCLE were the different sized structures mainly clustered around hair follicles, while LLP demonstrated dense structures with a scattered distribution. RCM may be used to distinguish between the key features of LS, LPs, LCLE and LLP in children.
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  • 文章类型: Case Reports
    线形硬伤,也被称为线性硬皮病,是一种局部形式的硬皮病,其特征是存在遵循线性分布模式的病变。除了典型的皮肤炎症和纤维化,硬叶的线性亚型通常会影响肌肉和骨骼等基础结构,这可能导致功能限制。纹状体苔藓,线性炎症皮肤状况,主要影响5至15岁的儿童。有趣的是,这两种疾病都可以表现出遵循Blaschko路线的病变。在这里,我们报告了一个4岁儿童的Blaschko模仿地衣纹状体的线性硬斑病例。这个独特的病例代表了第一个记录的线性morphea实例,显示出精确的Blaschko模式,并成功地用baricitinib治疗。患者接受口服baricitinib,每日剂量2mg,持续1年,导致显著的改善。大多数病变软化了,并且在整个治疗期间没有显著的疾病进展或不良事件的发生.在早期阶段识别线性硬皮对于确保有效治疗和防止毁容后遗症至关重要。怀疑患有扁平苔藓的患者也应密切随访,并在随访期间排除线性硬皮。本文还对巴利替尼在硬皮病中的应用和安全性方面的最新进展进行了综述。
    Linear morphea, also known as linear scleroderma, is a localized form of scleroderma characterized by the presence of lesions that follow a linear distribution pattern. Apart from the typical inflammation and fibrosis of the skin, the linear subtype of morphea often affects underlying structures such as muscles and bones, which can lead to functional limitations. Lichen striatus, a linear inflammatory skin condition, primarily affects children aged 5 to 15 years. Interestingly, both diseases can exhibit lesions that follow the lines of Blaschko. Here we report a case with linear morphea following the lines of Blaschko mimicking lichen striatus in a 4-year-old child. This unique case represents the first documented instance of linear morphea exhibiting a precise Blaschko pattern and being successfully treated with baricitinib. The patient received oral baricitinib at a daily dosage of 2 mg for a duration of 1 year, resulting in remarkable improvement. The majority of the lesions softened, and there was no significant disease progression or occurrence of adverse events throughout the treatment period. Recognizing linear morphea at an early stage is of utmost importance in ensuring effective treatment and preventing disfiguring sequelae. Patients suspected of lichen striatus should also be closely followed and linear morphea should be excluded during the follow-up. The recent breakthrough in the application and the safety of baricitinib in scleroderma is also reviewed.
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  • 文章类型: Review
    Morphea是一种罕见的炎症和纤维化疾病,具有多形性临床表现。我们报告了两例在先前的良性皮肤病后发展为同位素反应的情况,伴随着对文献的回顾。该病例系列强调了恢复对良性皮肤状况的护理建议的重要性,例如纹状体苔藓和色素性紫癜性皮肤病,因为随后很少发生硬斑。
    Morphea is an uncommon inflammatory and fibrosing disorder that has a polymorphous clinical presentation. We report two cases of morphea developing as an isotopic response after a preceding benign skin disease, accompanied by a review of the literature. This case series highlights the importance of return to care recommendations for benign skin conditions such lichen striatus and pigmented purpuric dermatoses due to the rare possibility of subsequent morphea development.
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  • 文章类型: Journal Article
    在这项回顾性研究中,我们分析了30例扁平苔藓患者(年龄<18岁)的记录。70%为女性,30%为男性,诊断平均年龄为5.38±4.22岁。受影响的最常见年龄组为0-4岁。扁平苔藓的平均持续时间为6.66±4.22个月。9例(30%)患者存在特应性。虽然LS是一种良性的自限性皮肤病,对更多患者进行的长期前瞻性研究将有助于更好地了解该疾病,包括其病因和与特应性疾病的关系。
    We analyzed records of 30 patients with lichen striatus (age < 18 years) in this retrospective study. Seventy percent were females and 30% were males with a mean age of diagnosis of 5.38 ± 4.22 years. The most common age group affected was 0-4 years. The mean duration of lichen striatus was 6.66 ± 4.22 months. Atopy was present in 9 (30%) patients. Although LS is a benign self-limited dermatosis, long-term prospective studies with a greater number of patients will help in better understanding of the disease including its etiopathogenesis and association with atopy.
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  • 文章类型: Journal Article
    炎症后色素沉着减退是一种常见的获得性色素障碍,在皮肤颜色上更为突出,导致巨大的美容和社会心理影响。通常,色素性疾病的诊断会对个体的健康相关生活质量产生负面影响,并可能导致污名化。尽管大多数炎症后色素沉着减退病例随时间自发消退,系统的诊断方法可以帮助确定潜在的病因并告知治疗策略.可能是由于皮肤炎症,炎症性或感染性皮肤病的后遗症,或皮肤病学程序。因此,对流行病学的透彻了解,病史,体检结果,炎症后色素减退现象的临床特征可以向提供者解释主要原因,并允许对患者进行教育。了解各种可用的治疗方法和这些选择的功效也很重要,这将告知提供者为患者选择合适的治疗方法。尽管存在对获得性色素沉着减退疾病进行分类的算法,对于炎症后色素减退的诊断和治疗,目前还没有确定的算法,这值得进一步探索和讨论。
    Post-inflammatory hypopigmentation is a common acquired pigmentary disorder that is more prominent in skin of color, leading to great cosmetic and psychosocial implications. Often, a diagnosis with a pigmentary disorder can negatively impact an individual\'s health-related quality of life and may result in stigma. Although most cases of post-inflammatory hypopigmentation resolve spontaneously over time, a systematic diagnostic approach can help with identifying the underlying etiology and informing treatment strategies. It can be due to cutaneous inflammation, sequelae of inflammatory or infectious dermatoses, or dermatologic procedures. Therefore, a thorough understanding of the epidemiology, patient history, physical exam findings, and clinical features of post-inflammatory hypopigmentation phenomenon can explain the primary cause to providers and allow for patient education. It is also important to understand the various therapeutic approaches available and the efficacy of these options, which will inform providers to choose the appropriate therapy for patients. Although algorithms exist for classifying acquired disorders of hypopigmentation, there are no established algorithms for the diagnosis and treatment of post-inflammatory hypopigmentation, which warrants further exploration and discourse.
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  • 文章类型: Journal Article
    背景技术皮肤病是儿科年龄组中的主要健康问题,并且与显著的发病率相关。丘疹鳞状疾病,构成儿童皮肤病的主要部分,目前在各种临床模式。进行这项研究是为了研究儿科年龄组(2-14岁)的丘疹鳞状疾病的医院患病率,并确定其年龄和性别分布的形态和临床模式。方法2019年12月1日至2021年5月30日在皮肤科门诊进行了分析性横断面研究,性病,和Legrology,JK医院和LN医学院,博帕尔,印度。属于2-14岁年龄组的95名连续患者,参加皮肤科OPD的患者以及儿科转诊的病例均纳入研究.详细的病史,关于年龄,持续时间,发病,症状,复发,家族史,预先存在的医疗条件,并记录了药物摄入史。关于发烧史的信息,喉咙痛,并注意到疫苗接种。临床和皮肤病学检查,包括头发,钉,所有病例均行粘膜检查。对相关病例进行了必要的调查,并以专门为研究设计的形式记录了数据。结果在本研究中,丘疹鳞状疾病占所有儿科(2-14岁)皮肤病的2.9%。在发现的各种丘疹鳞状疾病中,牛皮癣是最常见的疾病(31.6%),其次是Gianotti-Crosti综合征(18.9%),和扁平苔藓(18.9%)。男性人数超过女性,比例为1.48:1。在本研究中,丘疹鳞状疾病的发生率在11-14岁之间最高。结论丘疹鳞状疾病在整个皮肤病中占很大比例,属于成人和儿童人群。由于临床表现的显著变化,地理和环境影响,治疗,和预后;与成人皮肤病相比,儿童丘疹鳞状疾病组需要不同的治疗方法。在这一领域需要更多的研究来适当地诊断和管理小儿丘疹鳞状疾病,以减少疾病负担,并作为更好的患者护理的关键。
    Introduction Skin disorders are a major health problem in the pediatric age group and are associated with significant morbidity. Papulosquamous disorders, forming a major part of the skin diseases in children, present in a variety of clinical pattern. This study is conducted in order to study the hospital-based prevalence of papulosquamous disorders in the pediatric age group (2-14 years) and to determine the morphology and clinical patterns with respect to their age and sex distribution. Methodology An analytical cross-sectional study was conducted from December 1, 2019, to May 30, 2021, in the outpatient department of the Department of Dermatology, Venereology, and Leprology, JK Hospital and LN Medical College, Bhopal, India. Ninety-five consecutive patients belonging to the age group of 2-14 years, attending the Dermatology OPD and also referred cases from the Pediatrics Department were enrolled in the study. A detailed history of illness, regarding age, duration, onset, symptoms, recurrence, family history of the disease, pre-existing medical conditions, and drug intake history was taken. Information regarding the history of fever, sore throat, and vaccination was noted. Clinical and dermatological examination including hair, nail, and mucosal examination was done for all the cases. Necessary investigations were ordered for relevant cases and the data was recorded in a form specially designed for the study. Results In the present study, papulosquamous disorders constituted 2.9% of all pediatric (2-14 years) dermatosis. Of the various papulosquamous disorders found, psoriasis was the most common disease that was found (in 31.6%) followed by Gianotti-Crosti syndrome (18.9%), and lichen planus (18.9%). Males outnumbered females with a ratio of 1.48:1. The incidence of papulosquamous disorders was highest in 11-14 years of age in the present study. Conclusion Papulosquamous disorders account for a large number of the overall dermatoses, belonging to both the adult and pediatric populations. Due to significant changes in clinical presentation, geographical and environmental influences, treatment, and prognosis; the papulosquamous group of disorders in children require a varying approach than adult dermatoses. More studies are required in this field to appropriately diagnose and manage pediatric papulosquamous disorders in order to reduce the disease burden and as a key to better patient care.
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  • 文章类型: Case Reports
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  • 文章类型: Journal Article
    A 7-year-old healthy girl presented with an 11-month history of an asymptomatic red, dome-shaped papule on her right medial elbow and 6-month history of linearly distributed, few millimeter, flesh-colored papules extending from and including the red papule. Histopathology demonstrated features of both a Spitz nevus and lichen striatus. The Spitz nevus was removed with a punch biopsy and the lichen striatus subsequently resolved. To our knowledge, co-localization of a Spitz nevus with lichen striatus has not been previously reported and highlights the potential association between the immunogenicity of Spitz nevi and the development of lichen striatus.
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  • 文章类型: Case Reports
    There have been many reports of congenital and acquired dermatoses that trail Blaschko lines. Lichen striatus is representative of an acquired cutaneous linear inflammatory dermatosis running along the lines of Blaschko, characterized histopathologically by the predominance of lichenoid infiltration. Adult blaschkitis, however, is considered under the same disease spectrum as lichen striatus and is characterized by a spongiotic reaction pattern. Few differences have been recognized between lichen striatus and adult blaschkitis such as age of onset, triggers, distribution, histopathology, and response to treatment. A case of male patient with adult blaschkitis presenting as unilateral asymptomatic erythematous edematous papules, papulovesicles, and plaques over Blaschko\'s lines, in which skin biopsy revealed coexistent pathological features of lichen striatus and adult blaschkitis along with blood eosinophilia, has been presented here. This may add to the cumulative evidence on the pathogenesis of adult blaschkitis as an allergic reaction to an unknown inciting allergen. Evidence to consider adult blaschkitis as part of the lichen striatus spectrum is growing. Triggers for such skin reactions remain diverse. This case presentation suggests that adult blaschkitis could be triggered by an allergic response evidenced by the blood eosinophilia when other causes of eosinophilia are excluded.
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