■吸烟对水通道蛋白4阳性抗体(NMOSD-AQP4)和髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)的视神经脊髓炎谱系障碍患者磁共振成像(MRI)病变分辨率的影响之前尚未研究。
■我们旨在确定吸烟对MRI病变分辨率的影响,并评估其与复发后临床恢复的相关性。
■我们进行了一项队列研究,包括NMOSD-AQP4和MOGAD患者的急性和随访MRI扫描。我们收集了人口统计,临床,成像和吸烟数据。采用Logistic回归模型预测吸烟对病灶消退的影响,并评估临床恢复是否与MRI病灶消退相关。
■共纳入105例患者(57例患者为NMOSD-AQP4,48例患者为MOGAD)。当前和过去吸烟与NMOSD-AQP4和MOGAD中持续性病变的风险较高相关(风险比(RR)=3.4,95%置信区间(CI)=2.5-4.7,p<0.001)。此外,病变消退的存在与更好的临床恢复相关(RR=1.9,95%CI=1.7-2.2,p<0.001).
■吸烟与NMOSD-AQP4和MOGAD患者的MRI病变分辨率较差相关,病变消退与临床恢复相关。我们的发现表明吸烟在炎性中枢神经系统(CNS)疾病中的有害作用。
The effect of smoking on the resolution of magnetic resonance imaging (MRI) lesions in patients with neuromyelitis optica spectrum disorders with aquaporin-4 positive antibody (NMOSD-AQP4) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has not been studied before.
We aimed to determine the effect of smoking on lesion resolution in MRI and assess its correlation with clinical recovery after a relapse.
We conducted a cohort study including NMOSD-AQP4 and MOGAD patients with acute and follow-up MRI scans. We collected demographic, clinical, imaging and smoking data. Logistic regression models were fitted to predict the effect of smoking on lesion resolution and to assess whether clinical recovery was associated with MRI lesion resolution.
A total of 105 patients were included (57 with NMOSD-AQP4 and 48 with MOGAD). Current and past smoking was associated with a higher risk of persistent lesions in NMOSD-AQP4 and MOGAD (risk ratio (RR) = 3.4, 95% confidence interval (CI) = 2.5-4.7, p < 0.001). Additionally, the presence of lesion resolution was associated with better clinical recovery (RR = 1.9, 95% CI = 1.7-2.2, p < 0.001).
Smoking is associated with worse MRI lesion resolution in patients with NMOSD-AQP4 and MOGAD, and lesion resolution correlates with clinical recovery. Our findings suggest a detrimental effect of smoking in inflammatory central nervous system (CNS) diseases.