对白内障发病机理的研究正在进行中,有关该主题的出版物数量每年都在增加。本研究概述了研究现状,热门话题,近几十年来白内障发病机制领域的学术趋势,这有助于指导未来的研究方向,优化资源配置。在本研究中,我们对白内障的发病机制进行了文献计量学分析.1999年1月1日至2023年12月20日的出版物是从WebofScienceCoreCollection(WoSCC)收集的,并对提取的数据进行量化分析。我们使用MicrosoftExcel分析和呈现数据,VOSviewer,CiteSpace,和Python。总之,4006篇文章根据各种特征进行了评估,包括出版年份,作者,国家,机构,期刊,引文,和关键词。本研究利用VOSviewer进行可视化分析,包括合著者,共同引文,共现,和网络可视化。CiteSpace软件用于识别具有显著活动爆发的关键词。从1999年到2023年,全球年度出版物数量从76种增加到277种,增长了264.47%。实验眼研究发表了最多的手稿(178种出版物),而调查眼科学和视觉科学获得的引用最多(6675次引用)。最有影响力和生产力的国家,机构,作者是美国(1244种出版物,54,456条引文),加州大学系统(136种出版物,5401引用),和姚克(49种出版物,838次引用),分别。排名前100位的关键词通过共现分析分为四个簇:(1)继发性白内障,(2)氧化应激,(3)基因突变和蛋白异常,(4)晶状体上皮细胞生物学过程的改变。关于四个子主题的进一步讨论概述了研究主题和趋势。总之,白内障形成的具体机制仍然是未来研究的热门课题,应进行更深入的探索。
Research on the pathogenesis of cataracts is ongoing and the number of publications on this topic is increasing annually. This study offers an overview of the research status, popular topics, and scholarly tendencies in the field of cataract pathogenesis over recent decades,which helps to guide future research directions, and optimize resource allocation. In the present study, we performed a bibliometric analysis of cataract pathogenesis. Publications from January 1, 1999, to December 20, 2023, were collected from the Web of Science Core Collection (WoSCC), and the extracted data were quantified and analyzed. We analyzed and presented the data using Microsoft Excel, VOSviewer, CiteSpace, and Python. In all, 4006 articles were evaluated based on various characteristics, including publication year, authors, countries, institutions, journals, citations, and keywords. This study utilized VOSviewer to conduct visualized analysis, including co-authorship, co-citation, co-occurrence, and network visualization. The CiteSpace software was used to identify keywords with significant bursts of activity. The number of annual global publications climbed from 76 to 277 between 1999 and 2023, a 264.47% rise. Experimental Eye Research published the most manuscripts (178 publications), whereas Investigative Ophthalmology & Visual Science received the most citations (6675 citations). The most influential and productive country, institution, and author were the United States (1244 publications, 54,456 citations), University of California system (136 publications, 5401 citations), and Yao Ke (49 publications, 838 citations), respectively. The top 100 ranked keywords are divided into four clusters through co-occurrence analysis: (1) secondary cataracts, (2) oxidative stress, (3) gene mutations and protein abnormalities, and (4) alteration of biological processes in lens epithelial cells. Further discussions on the four subtopics outline the research topics and trends. In conclusion, the specific mechanism of cataract formation remains a popular topic for future research and should be explored in greater depth.