人脑的一个突出的神经解剖学特征是其明显的皮质折叠,越来越多的证据表明,脑沟形态与功能性脑结构和认知有关。最近的研究强调了推定的三级沟(pTS):小,浅,后期开发,和进化上新的沟,已被假定为联合皮质中的功能标志。表征大脑结构的一种卓有成效的方法是根据基于功能磁共振成像的功能连接谱中的过渡来描绘区域;然而,精确的区域边界可以根据用于生成分割的数据而改变。因为沟是固定的神经解剖结构,在这里,我们建议将功能连接锚定到个体水平的沟解剖结构。我们在儿科样本(N=43;女性20;年龄7-18)中,在外侧前额叶(LPFC)和外侧顶叶皮质(LPC)的42个沟中表征了功能连接的细粒度模式。Further,我们测试了pTS形态和功能网络体系结构之间的关系,关注深度作为这些浅沟的定义特征,并且与认知的变异性有关。我们发现1)个体沟具有不同的连通性模式,但尽管如此,聚集在一起,形成相似模式的群体——在某些情况下,具有遥远的而不是相邻的沟,2)在小组和个人级别的集群分配中存在适度的一致性,强调个人层面分析的必要性,和3)跨个人,对于几个pTS,更大的深度与更高的网络中心性相关。这些结果强调了考虑个体沟形态对于理解功能性脑组织的重要性。
■一个显著的,和功能相关,人脑的特征是其明显的皮质折叠。然而,沟解剖和脑功能之间的联系仍然知之甚少-特别是对于小,浅,缔合皮质中的个体可变沟。这里,我们探讨了外侧前额叶和顶叶区单独定义的沟之间的功能连接。我们发现单个沟具有不同的连通性模式,但仍聚集在一起,具有相似的连通性-在某些情况下,横跨外侧前额叶和顶沟。我们进一步表明,特定沟的网络中心性与其深度呈正相关,从而帮助弥合大脑解剖和功能网络中的个体差异之间的差距,利用个体的沟解剖。
A salient neuroanatomical feature of the human brain is its pronounced cortical folding, and there is mounting evidence that sulcal morphology is relevant to functional brain architecture and cognition. Recent studies have emphasized putative tertiary sulci (pTS): small, shallow, late-developing, and evolutionarily new sulci that have been posited to serve as functional landmarks in association cortices. A fruitful approach to characterizing brain architecture has been to delineate regions based on transitions in fMRI-based functional connectivity profiles; however, exact regional boundaries can change depending on the data used to generate the parcellation. As sulci are fixed neuroanatomical structures, here, we propose to anchor functional connectivity to individual-level sulcal anatomy. We characterized fine-grained patterns of functional connectivity across 42 sulci in lateral prefrontal (LPFC) and lateral parietal cortices (LPC) in a pediatric sample (N = 43; 20 female; ages 7-18). Further, we test for relationships between pTS morphology and functional network architecture, focusing on depth as a defining characteristic of these shallow sulci, and one that has been linked to variability in cognition. We find that 1) individual sulci have distinct patterns of connectivity, but nonetheless cluster together into groups with similar patterns - in some cases with distant rather than neighboring sulci, 2) there is moderate agreement in cluster assignments at the group and individual levels, underscoring the need for individual-level analyses, and 3) across individuals, greater depth was associated with higher network centrality for several pTS. These results highlight the importance of considering individual sulcal morphology for understanding functional brain organization.
UNASSIGNED: A salient, and functionally relevant, feature of the human brain is its pronounced cortical folding. However, the links between sulcal anatomy and brain function are still poorly understood - particularly for small, shallow, individually variable sulci in association cortices. Here, we explore functional connectivity among individually defined sulci in lateral prefrontal and parietal regions. We find that individual sulci have distinct patterns of connectivity but nonetheless cluster together into groups with similar connectivity - in some cases spanning lateral prefrontal and parietal sulci. We further show that the network centrality of specific sulci is positively associated with their depth, thereby helping to bridge the gap between individual differences in brain anatomy and functional networks leveraging the sulcal anatomy of the individual.