■我们的目的是研究妊娠晚期胎膜早破(PROM)孕妇的母体中性粒细胞比率与组织学绒毛膜羊膜炎(HCA)风险之间的关系。
■对2018年3月至2021年8月期间妊娠晚期的95例PROM妇女进行了回顾性分析。根据HCA的存在将这些妇女分为两组。比较两组患者的一般临床资料和实验室指标。采用广义加性模型进行曲线拟合,使用分段回归模型进一步解释中性粒细胞比率与HCA风险之间的非线性关系.
■调整混杂因素后,曲线拟合显示中性粒细胞比率与HCA风险之间呈“U”形曲线关系。当中性粒细胞比率<76.3%时,HCA的风险呈下降趋势,但差异无统计学意义(校正OR=0.884,95%CI:0.781~1.001,P=0.053)。然而,当中性粒细胞比率>76.3%时,HCA风险显著增加(校正OR=1.339,95%CI:1.067~1.680,P=0.012)。此外,我们将中性粒细胞比率平均分为三组.低比率组较中比率组发生HCA的风险明显增加(OR=4.292,95%CI:1.247~14.706,P=0.021),用作参考组。同样,高比例组的HCA风险(OR=13.145,95%CI:1.796~96.233,P=0.011)也显著升高.然而,高比率组和低比率组之间的HCA风险无显著差异(OR=1.182,95%CI:0.357-3.909,P=0.784)。
■妊娠晚期胎膜早破妇女的母体中性粒细胞比率与HCA风险之间存在显着的“U”形关系。
UNASSIGNED: We aimed to investigate the association between maternal neutrophil ratio and histological chorioamnionitis (HCA) risk in pregnant women with premature rupture of membranes (PROM) in late pregnancy.
UNASSIGNED: A retrospective analysis was conducted on 95 cases of women with PROM in their late pregnancy between March 2018 and August 2021. These women were divided into two groups based on the presence of HCA. General clinical data and laboratory indicators were compared between the two groups. A generalized additive model was used for curve fitting, and a segmented regression model was used to explain further the non-linear relationship between neutrophil ratio and HCA risk.
UNASSIGNED: After adjusting for confounding factors, the curve fitting showed a \"U\"-shaped curve relationship between the neutrophil ratio and the risk of HCA. When the neutrophil ratio was <76.3%, the risk of HCA exhibited a decreasing trend, but the difference was not statistically significant (adjusted OR = 0.884, 95% CI: 0.781-1.001, P = 0.053). However, when the neutrophil ratio was >76.3%, the HCA risk was significantly increased (adjusted OR = 1.339, 95% CI: 1.067-1.680, P = 0.012). Furthermore, we equally divided the neutrophil ratio into three groups. The risk of HCA was significantly increased in the low-ratio group (OR = 4.292, 95% CI: 1.247-14.706, P = 0.021) compared with the middle-ratio group, which was used as the reference group. Similarly, the HCA risk of the high-ratio group (OR = 13.145, 95% CI: 1.796-96.233, P = 0.011) was also significantly enhanced. However, there was no significant difference in HCA risk between the high-ratio and low-ratio groups (OR = 1.182, 95% CI: 0.357-3.909, P = 0.784).
UNASSIGNED: There was a significant \"U\"-shaped relationship between maternal neutrophil ratio and HCA risk in women with PROM in late pregnancy.