皮脂腺的选择性光热分解有可能成为治疗寻常痤疮的有效替代方法。然而,由于缺乏针对皮脂腺的适当能量来源，这种技术在临床环境中的应用受到了阻碍，围绕安全的问题，以及与治疗相关的不适和停机时间。在这项工作中,我们引入了第一个FDA批准的系统，该系统结合了1726nm激光和有效的接触冷却来治疗轻度，中度,和严重的痤疮有效，同时确保安全和最小的患者不适，没有辅助疼痛缓解技术。进行光传输和生物传热模拟以证明系统的功效和选择性。使用Arrhenius动力学模型对皮肤和皮脂腺的热损伤进行建模。数值模拟表明，结合激光能量和最佳接触冷却可以引起空间上仅限于皮脂腺的显着温度升高；这导致高度选择性的靶向和对皮脂腺的最大损伤，同时保留其他皮肤结构。体内人体面部皮肤组织学结果证实了模拟结果。这里报道的研究表明，提出的1726nm激光系统诱导皮脂腺的选择性光热解，为寻常痤疮的治疗提供了一种安全有效的方法。
Selective photothermolysis of the sebaceous glands has the potential to be an effective alternative for treating acne vulgaris. However, the translation of this technique to clinical settings has been hindered by a lack of appropriate energy sources to target sebaceous glands, concerns surrounding safety, and treatment-related discomfort and downtime. In this work, we introduce the first FDA-approved system that combines a 1726-nm laser and efficient contact cooling to treat mild, moderate, and severe acne effectively while ensuring safety and minimal patient discomfort without adjunct pain mitigation techniques. Light transport and bioheat transfer simulations were performed to demonstrate the system\'s efficacy and selectivity. The resulting thermal damage to the skin and sebaceous glands was modeled using the Arrhenius kinetic model. Numerical simulations demonstrated that combining laser energy and optimal contact cooling could induce a significant temperature increase spatially limited to the sebaceous gland; this results in highly selective targeting and maximum damage to the sebaceous gland while preserving other skin structures. In vivo human facial skin histology results corroborated the simulation results. The studies reported here demonstrate that the presented 1726-nm laser system induces selective photothermolysis of the sebaceous gland, providing a safe and effective method for the treatment of acne vulgaris.
