背景:腹腔镜子宫内膜瘤切除术和随后的止血对卵巢储备有不利影响。
目的:评估剥除膀胱术后哪种止血方法对卵巢储备损伤较小。
方法:EMBASE,MEDLINE,Scopus,Scielo.br,LILACS,中环的Cochrane,Clinicaltrials.gov,CINAHL,从开始至2022年4月,我们检索了会议摘要和国际对照试验登记处.
方法:接受腹腔镜子宫内膜瘤切除术的妇女的随机对照试验(RCT),比较了至少两种止血方法。
方法:提取相关数据并制成表格。进行基于随机效应模型的网络荟萃分析,用于混合多种治疗,以使用累积排序曲线面积(SUCRA)下的表面对止血策略进行排序。使用Cochrane标准进行质量评估。主要结果是手术后3个月的血清抗苗勒管激素(AMH)水平。
结果:十项研究,包括748名女性,被选中。用倒钩缝合卵巢(SUCRA=82.80%)似乎是避免AMH减少的最有效策略。同样,超声检查窦卵泡计数,倒刺(SUCRA=30.70%)和简单缝线(SUCRA=30.70%)是最佳选择。简单缝合的卵巢缝合显示较低的FSH水平(SUCRA=88.70%)。
结论:缝合卵巢,用简单或带刺的缝线,似乎最有效的方法来保持卵巢储备较高。
BACKGROUND: Laparoscopic excision of endometrioma and subsequent hemostasis have detrimental effects on ovarian reserve.
OBJECTIVE: To evaluate which hemostatic approach after stripping cystectomy shows less damage on ovarian reserve.
METHODS: Embase, MEDLINE, Scopus, Scielo.br, LILACS, Cochrane Library at the CENTRAL Register of Controlled Trials, Clinicaltrials.gov, CINAHL, conference abstracts, and International Clinical Trials Registry Platform were searched from inception until April 2022.
METHODS: Randomized controlled trials of women undergoing laparoscopic endometrioma excision that compared at least two hemostatic approaches.
METHODS: Relevant data were extracted and tabulated. Network meta-analysis based on random-effects model for mixed multiple treatment to rank hemostatic strategies using the surface under the cumulative ranking curve area (SUCRA) was performed. Quality assessment was performed using Cochrane criteria. The primary outcome was serum antimullerian hormone levels 3 months after surgery.
RESULTS: Ten studies, including 748 women, were selected. Suturing the ovary with barbed suture (SUCRA, 82.80%) seem the most effective strategy to avoid antimullerian hormone reduction. Similarly, for ultrasonographic antral follicular count, barbed (SUCRA, 30.70%) and simple suture (SUCRA, 30.70%) were ranked the best choices. Ovarian suturing with simple suture demonstrated lower follicle-stimulating hormone levels (SUCRA, 88.70%).
CONCLUSIONS: Suturing the ovary, with simple or barbed suture, seems the most effective approach to keep ovarian reserve higher.