背景:慢性便秘是一种常见的胃肠道疾病,其特征是排便不频繁或困难,显著影响患者的生活质量。实验室标志物在识别与慢性便秘相关的生理变化方面提供了潜在的诊断价值。然而,它们的有效性仍未得到充分开发。
目的:本研究的目的是评估各种实验室检查在确定成人慢性便秘的潜在原因方面的诊断价值。
方法:在都胡克的库尔德斯坦私立医院和Jeen诊所进行了一项横断面研究,库尔德斯坦,伊拉克,从2022年12月到2024年5月。共纳入132名符合罗马IV标准的慢性便秘患者。数据收集涉及人口统计信息,生活方式因素,和实验室测试,包括全血细胞计数(CBC),促甲状腺激素(TSH),血清钙,血清钾,血清葡萄糖,血清肌酐,甲状旁腺激素(PTH),和维生素D水平。
结果:研究人群包括56名男性(42.4%)和76名女性(57.6%),平均年龄为46.5岁(SD=17岁),范围为18-81岁。只有56名(42.4%)患者进行了定期运动,85例(64.4%)患者每天饮水量不足2升水,108例(81.8%)超重或肥胖.在研究人群中,27例(20.4%)检测到甲状腺功能减退,甲状旁腺功能亢进27例(20.4%),58(44%)贫血,白细胞增多症24例(18.2%),48例(36.4%)肾损害,低钾血症中的四个(3%),高钾血症12例(9.1%),低钙血症10例(7.6%),高钙血症12例(9.1%),空腹血糖受损46例(34.8%),21例高血糖(15.9%),和维生素D缺乏的80(60.6%)。在研究人群中,40例(30%)患者的实验室检查小组正常。
结论:在慢性便秘中,实验室检查在成人中具有很高的诊断率,对于排除慢性便秘的次要原因至关重要。慢性便秘患者普遍存在不健康的生活方式。
BACKGROUND: Chronic constipation is a common gastrointestinal complaint characterized by infrequent or difficult bowel movements, significantly affecting patients\' quality of life. Laboratory markers offer potential diagnostic value in identifying physiological changes associated with chronic constipation, yet their effectiveness remains underexplored.
OBJECTIVE: The objective of this study was to evaluate the diagnostic value of various laboratory tests in identifying the underlying causes of chronic constipation among adults.
METHODS: A cross-sectional study was conducted at Kurdistan Private Hospital and Jeen Clinics in Duhok, Kurdistan, Iraq, from December 2022 to May 2024. A total of 132 patients meeting the Rome IV criteria for chronic constipation were included. Data collection involved demographic information, lifestyle factors, and laboratory tests, including complete blood count (CBC), thyroid stimulating hormone (TSH), serum calcium, serum potassium, serum glucose, serum creatinine, parathyroid hormone (PTH), and vitamin D levels.
RESULTS: The study population consisted of 56 males (42.4%) and 76 females (57.6%) with a mean age of 46.5 years (SD=17 years) and a range of 18-81 years. Regular exercise was performed by only 56 (42.4%) patients, 85 (64.4%) patients were drinking less than 2 liters of water per day, and 108 (81.8%) were overweight or obese. Of the study population, hypothyroidism was detected in 27 (20.4%), hyperparathyroidism in 27 (20.4%), anemia in 58 (44%), leukocytosis in 24 (18.2%), renal impairment in 48 (36.4%), hypokalemia in four (3%), hyperkalemia in 12 (9.1%), hypocalcemia in 10 (7.6%), hypercalcemia in 12 (9.1%), impaired fasting glucose in 46 (34.8%), hyperglycemia in 21 (15.9%), and vitamin D deficiency in 80 (60.6%). Of the study population, 40 (30%) patients had normal laboratory investigations panel.
CONCLUSIONS: In chronic constipation, laboratory tests have high diagnostic yield in adults and are essential for ruling out secondary causes of chronic constipation. Unhealthy lifestyles are prevalent in patients with chronic constipation.