■肺癌,其特点是发病率和致死率高,有必要进行深入研究,以增强我们对其发病机理的理解并发现新的治疗方法。最近的研究越来越证明肺癌细胞可以调节肿瘤微环境,促进肿瘤生长,通过外泌体的释放进行转移。外泌体是细胞分泌的小囊泡,含有多种生物活性分子,如蛋白质,核酸,和代谢物。本文通过文献计量分析,对肺癌的外泌体研究及其进展进行了全面综述。
■在WebofScienceCoreCollection(WoSCC)数据库上系统地搜索了与肺癌患者外泌体相关的出版物。使用VOSviwers进行文献计量分析,CiteSpace,和R包“Bibliometrics”。使用MicrosoftOfficeExcel2019对出版物进行定量分析。出版语言仅限于“英语”,搜索策略采用TS=(外泌体或外泌体或外泌体)和TS=(肺癌)。搜索期于2004年1月1日开始,并于2023年11月12日中午结束。选择的文献类型包括文章和评论。
■该研究包含来自71个国家和2105个机构的521种期刊的1699篇论文。分析显示,多年来肺癌外泌体研究呈持续上升趋势,最近出现了显著的激增。这种激增表明对肺癌外泌体的兴趣和研究深度日益增长。中国和美国的主要研究机构,包括南京医科大学,上海交通大学,中国科学院,和Utmd安德森癌症中心,成为重要的研究中心。该领域的年度出版物数量持续增长,尤其是近年来。关键术语如肺癌,非小细胞肺癌(NSCLC),微泡,细胞间通讯,外泌体miRNA,肿瘤学主导了研究领域。像细胞生物学这样的领域,生物化学,生物技术,肿瘤学与这项研究有着密切的关系。ClotildeThéry成为该领域被引用最多的作者,强调她的重要贡献。这些结果证明了外泌体研究对肺癌的广泛影响,关键术语不仅涵盖肺癌和非小细胞肺癌等疾病特异性方面,还涵盖微泡和细胞间通讯等基本生物学概念。对外泌体microRNAs和肿瘤学的探索为肺癌外泌体研究开辟了新的途径。总之,肺癌外泌体研究有望继续受到关注,可能导致治疗和预防方面的突破。
■有关肺癌外泌体的出版物呈逐年上升趋势,中国和美国在出版物数量上排名第一和第二。然而,双方学术学习合作与交流不足,而中国大学在这一领域的研究机构中占很大比例。李静是最有成效的作家,ClotildeThéry是被引用最多的作者,癌症是出版物数量最多的杂志。目前肺癌外泌体领域的焦点是生物标志物,液体活检,免疫疗法,和肿瘤微环境。
UNASSIGNED: Lung cancer, characterized by its high morbidity and lethality, necessitates thorough research to enhance our understanding of its pathogenesis and discover novel therapeutic approaches. Recent studies increasingly demonstrate that lung cancer cells can modulate the tumor microenvironment, promoting tumor growth, and metastasis through the release of exosomes. Exosomes are small vesicles secreted by cells and contain a variety of bioactive molecules such as proteins, nucleic acids, and metabolites. This paper presents a comprehensive review of exosome research in lung cancer and its progress through bibliometric analysis.
UNASSIGNED: Publications related to exosomes in lung cancer patients were systematically searched on the Web of Science Core Collection (WoSCC) database. Bibliometric analysis was performed using VOSviwers, CiteSpace, and the R package \"Bibliometrics\". Publications were quantitatively analyzed using Microsoft Office Excel 2019. The language of publication was restricted to \"English\" and the search strategy employed TS=(exosomes or exosomes or exosomes) and TS=(lung cancer). The search period commenced on January 1, 2004, and concluded on November 12, 2023, at noon. The selected literature types included Articles and Reviews.
UNASSIGNED: The study encompassed 1699 papers from 521 journals across 71 countries and 2105 institutions. Analysis revealed a consistent upward trend in lung cancer exosome research over the years, with a notable surge in recent times. This surge indicates a growing interest and depth of inquiry into lung cancer exosomes. Major research institutions in China and the United States, including Nanjing Medical University, Shanghai Jiao Tong University, Chinese Academy Of Sciences, and Utmd Anderson Cancer Center, emerged as crucial research hubs. The annual publication count in this field witnessed a continuous rise, particularly in recent years. Key terms such as lung cancer, non-small cell lung cancer (NSCLC), microvesicles, intercellular communication, exosomal miRNAs, and oncology dominated the research landscape. Fields like cell biology, biochemistry, biotechnology, and oncology exhibited close relation with this research. Clotilde Théry emerged as the most cited author in the field, underlining her significant contributions. These results demonstrate the broad impact of exosome research in lung cancer, with key terms covering not only disease-specific aspects such as lung cancer and NSCLC but also basic biological concepts like microvesicles and intercellular communication. Explorations into exosomal microRNAs and oncology have opened new avenues for lung cancer exosome research. In summary, lung cancer exosome research is poised to continue receiving attention, potentially leading to breakthroughs in treatment and prevention.
UNASSIGNED: Publications on lung cancer exosomes show a rising trend year by year, with China and the United States ranking first and second in terms of the number of publications. However, there is insufficient academic learning cooperation and exchanges between the two sides, and Chinese universities account for a large proportion of research institutions in this field. Jing Li is the most productive author, Clotilde Théry is the most co-cited author, and Cancers is the journal with the highest number of publications. The current focus in the field of lung cancer exosomes is on biomarkers, liquid biopsies, immunotherapy, and tumor microenvironment.