Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative condition leading to progressive muscle weakness, atrophy, and ultimately death. Traditional ALS clinical evaluations often depend on subjective metrics, making accurate disease detection and monitoring disease trajectory challenging. To address these limitations, we developed the nQiALS toolkit, a machine learning-powered system that leverages smartphone typing dynamics to detect and track motor impairment in people with ALS. The study included 63 ALS patients and 30 age- and sex-matched healthy controls. We introduce the three core components of this toolkit: the nQiALS-Detection, which differentiated ALS from healthy typing patterns with an AUC of 0.89; the nQiALS-Progression, which separated slow and fast progression at specific thresholds with AUCs ranging between 0.65 and 0.8; and the nQiALS-Fine Motor, which identified subtle progression in fine motor dysfunction, suggesting earlier prediction than the state-of-the-art assessment. Together, these tools represent an innovative approach to ALS assessment, offering a complementary, objective metric to traditional clinical methods and which may reshape our understanding and monitoring of ALS progression.

In an era marked by escalating concerns about digital security, biometric identification methods have gained paramount importance. Despite the increasing adoption of biometric techniques, keystroke dynamics analysis remains a less explored yet promising avenue. This study highlights the untapped potential of keystroke dynamics, emphasizing its non-intrusive nature and distinctiveness. While keystroke dynamics analysis has not achieved widespread usage, ongoing research indicates its viability as a reliable biometric identifier. This research builds upon the existing foundation by proposing an innovative deep-learning methodology for keystroke dynamics-based identification. Leveraging open research datasets, our approach surpasses previously reported results, showcasing the effectiveness of deep learning in extracting intricate patterns from typing behaviors. This article contributes to the advancement of biometric identification, shedding light on the untapped potential of keystroke dynamics and demonstrating the efficacy of deep learning in enhancing the precision and reliability of identification systems.

BACKGROUND: Mental fatigue is a common and potentially debilitating state that can affect individuals\' health and quality of life. In some cases, its manifestation can precede or mask early signs of other serious mental or physiological conditions. Detecting and assessing mental fatigue can be challenging nowadays as it relies on self-evaluation and rating questionnaires, which are highly influenced by subjective bias. Introducing more objective, quantitative, and sensitive methods to characterize mental fatigue could be critical to improve its management and the understanding of its connection to other clinical conditions.
OBJECTIVE: This paper aimed to study the feasibility of using keystroke biometrics for mental fatigue detection during natural typing. As typing involves multiple motor and cognitive processes that are affected by mental fatigue, our hypothesis was that the information captured in keystroke dynamics can offer an interesting mean to characterize users\' mental fatigue in a real-world setting.
METHODS: We apply domain transformation techniques to adapt and transform TypeNet, a state-of-the-art deep neural network, originally intended for user authentication, to generate a network optimized for the fatigue detection task. All experiments were conducted using 3 keystroke databases that comprise different contexts and data collection protocols.
RESULTS: Our preliminary results showed area under the curve performances ranging between 72.2% and 80% for fatigue versus rested sample classification, which is aligned with previously published models on daily alertness and circadian cycles. This demonstrates the potential of our proposed system to characterize mental fatigue fluctuations via natural typing patterns. Finally, we studied the performance of an active detection approach that leverages the continuous nature of keystroke biometric patterns for the assessment of users\' fatigue in real time.
CONCLUSIONS: Our results suggest that the psychomotor patterns that characterize mental fatigue manifest during natural typing, which can be quantified via automated analysis of users\' daily interaction with their device. These findings represent a step towards the development of a more objective, accessible, and transparent solution to monitor mental fatigue in a real-world environment.

Keystroke dynamics is a soft biometric based on the assumption that humans always type in uniquely characteristic manners. Previous works mainly focused on analyzing the key press or release events. Unlike these methods, we explored a novel visual modality of keystroke dynamics for human identification using a single RGB-D sensor. In order to verify this idea, we created a dataset dubbed KD-MultiModal, which contains 243.2 K frames of RGB images and depth images, obtained by recording a video of hand typing with a single RGB-D sensor. The dataset comprises RGB-D image sequences of 20 subjects (10 males and 10 females) typing sentences, and each subject typed around 20 sentences. In the task, only the hand and keyboard region contributed to the person identification, so we also propose methods of extracting Regions of Interest (RoIs) for each type of data. Unlike the data of the key press or release, our dataset not only captures the velocity of pressing and releasing different keys and the typing style of specific keys or combinations of keys, but also contains rich information on the hand shape and posture. To verify the validity of our proposed data, we adopted deep neural networks to learn distinguishing features from different data representations, including RGB-KD-Net, D-KD-Net, and RGBD-KD-Net. Simultaneously, the sequence of point clouds also can be obtained from depth images given the intrinsic parameters of the RGB-D sensor, so we also studied the performance of human identification based on the point clouds. Extensive experimental results showed that our idea works and the performance of the proposed method based on RGB-D images is the best, which achieved 99.44% accuracy based on the unseen real-world data. To inspire more researchers and facilitate relevant studies, the proposed dataset will be publicly accessible together with the publication of this paper.

The paper addresses issues concerning secure authentication in computer systems. We focus on multi-factor authentication methods using two or more independent mechanisms to identify a user. User-specific behavioral biometrics is widely used to increase login security. The usage of behavioral biometrics can support verification without bothering the user with a requirement of an additional interaction. Our research aimed to check whether using information about how partial passwords are typed is possible to strengthen user authentication security. The partial password is a query of a subset of characters from a full password. The use of partial passwords makes it difficult for attackers who can observe password entry to acquire sensitive information. In this paper, we use a Siamese neural network and n-shot classification using past recent logins to verify user identity based on keystroke dynamics obtained from the static text. The experimental results on real data demonstrate that keystroke dynamics authentication can be successfully used for partial password typing patterns. Our method can support the basic authentication process and increase users\' confidence.

The safeguarding of online services and prevention of unauthorized access by hackers rely heavily on user authentication, which is considered a crucial aspect of security. Currently, multi-factor authentication is used by enterprises to enhance security by integrating multiple verification methods rather than relying on a single method of authentication, which is considered less secure. Keystroke dynamics is a behavioral characteristic used to evaluate an individual\'s typing patterns to verify their legitimacy. This technique is preferred because the acquisition of such data is a simple process that does not require any additional user effort or equipment during the authentication process. This study proposes an optimized convolutional neural network that is designed to extract improved features by utilizing data synthesization and quantile transformation to maximize results. Additionally, an ensemble learning technique is used as the main algorithm for the training and testing phases. A publicly available benchmark dataset from Carnegie Mellon University (CMU) was utilized to evaluate the proposed method, achieving an average accuracy of 99.95%, an average equal error rate (EER) of 0.65%, and an average area under the curve (AUC) of 99.99%, surpassing recent advancements made on the CMU dataset.

Can digital technologies provide a passive unobtrusive means to observe and study cognition outside of the laboratory? Previously, cognitive assessments and monitoring were conducted in a laboratory or clinical setting, allowing for a cross-sectional glimpse of cognitive states. In the last decade, researchers have been utilizing technological advances and devices to explore ways of assessing cognition in the real world. We propose that the virtual keyboard of smartphones, an increasingly ubiquitous digital device, can provide the ideal conduit for passive data collection to study cognition. Passive data collection occurs without the active engagement of a participant and allows for near-continuous, objective data collection. Most importantly, this data collection can occur in the real world, capturing authentic datapoints. This method of data collection and its analyses provide a more comprehensive and potentially more suitable insight into cognitive states, as intra-individual cognitive fluctuations over time have shown to be an early manifestation of cognitive decline. We review different ways passive data, centered around keystroke dynamics, collected from smartphones, have been used to assess and evaluate cognition. We also discuss gaps in the literature where future directions of utilizing passive data can continue to provide inferences into cognition and elaborate on the importance of digital data privacy and consent.

BACKGROUND: Mental disorders are prevalent during adolescence. Among the digital phenotypes currently being developed to monitor mental health symptoms, typing behavior is one promising candidate. However, few studies have directly assessed associations between typing behavior and mental health symptom severity, and whether these relationships differs between genders.
OBJECTIVE: In a cross-sectional analysis of a large cohort, we tested whether various features of typing behavior derived from keystroke metadata were associated with mental health symptoms and whether these relationships differed between genders.
METHODS: A total of 934 adolescents from the Future Proofing study undertook 2 typing tasks on their smartphones through the Future Proofing app. Common keystroke timing and frequency features were extracted across tasks. Mental health symptoms were assessed using the Patient Health Questionnaire-Adolescent version, the Children\'s Anxiety Scale-Short Form, the Distress Questionnaire 5, and the Insomnia Severity Index. Bivariate correlations were used to test whether keystroke features were associated with mental health symptoms. The false discovery rates of P values were adjusted to q values. Machine learning models were trained and tested using independent samples (ie, 80% train 20% test) to identify whether keystroke features could be combined to predict mental health symptoms.
RESULTS: Keystroke timing features showed a weak negative association with mental health symptoms across participants. When split by gender, females showed weak negative relationships between keystroke timing features and mental health symptoms, and weak positive relationships between keystroke frequency features and mental health symptoms. The opposite relationships were found for males (except for dwell). Machine learning models using keystroke features alone did not predict mental health symptoms.
CONCLUSIONS: Increased mental health symptoms are weakly associated with faster typing, with important gender differences. Keystroke metadata should be collected longitudinally and combined with other digital phenotypes to enhance their clinical relevance.
BACKGROUND: Australian and New Zealand Clinical Trial Registry, ACTRN12619000855123; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377664&isReview=true.

The data presented in this article comprises human-written samples of keystroke dynamic features for free-text inputs, in the form of sentences written in natural language, together with synthesized samples that share the same text sequences. The human-written samples originate in three publicly available datasets that have been previously used in several keystroke dynamics studies; the corresponding synthesized samples, which have been forged as detailed in the companion article, share the same keystroke sequences as the human-written ones to facilitate comparison. The human-written samples were collected, and the synthesized samples created, with the objective of training and evaluating a liveness detection model. For each human-written sample of each source dataset and each method, 25 synthetic samples were included in the dataset here presented; these were forged using five different methods, a between-subject profile (only samples from users other than the target were available to the attacker) or with varying partial knowledge of the legitimate users\' keystroke dynamics that ranged from only 100 keystrokes to all the available information. This dataset can be used by researchers to evaluate the performance of liveness detection methods for keystroke dynamics against a variety of state-of-the-art methods of sample synthesis.

Traditional polygraph techniques mostly rely on the changes of an individual\'s physiological indicators, such as electrodermal activity, heart rate, breath, eye movement and function of neural signals and other indicators. They are easily affected by individual physical conditions, counter-tests, external environment and other aspects, and it is difficult to conduct large-scale screening tests based on the traditional polygraph techniques. The application of keystroke dynamics to polygraph can overcome the shortcomings of the traditional polygraph techniques to a large extend, increase the reliability of polygraph results and promote the validity of legal evidence of polygraph results in forensic practice. This paper introduces keystroke dynamics and its application in deception research. Compared with the traditional polygraph techniques, keystroke dynamics can be used with a relatively wider application range, not only for deception research but also for identity identification, network screening and other large-scale tests. At the same time, the development direction of keystroke dynamics in the field of polygraph is prospected.
传统的测谎技术大多依赖个体的生理指标，如皮肤电、心率、呼吸、眼动和神经信号功能等指标的变化，容易受个体身体条件、反测试以及外部环境等方面的影响，并且很难进行大面积的筛查测试。将击键动力学应用于测谎可以很大程度上克服传统测谎技术的不足，增加测谎结果的可靠性，促进测谎结论在司法鉴定实践中的法定证据效力。本文介绍了击键动力学及其在欺骗研究中的应用，和传统测谎技术相比，击键动力学除了可以进行欺骗行为研究外，还可用于身份识别、网络筛查等大面积的测试，应用范围相对更广。同时，本文还对击键动力学在测谎领域的发展方向进行了展望。.