隐形矫正器已广泛用于正畸治疗,但仍存在牙菌斑形成和口腔粘膜磨损的问题,会导致复杂的口腔疾病。为了解决这些问题,具有润滑性的亲水性聚(磺基甜菜碱甲基丙烯酸酯)(聚SBMA)涂层,防污,和抗粘性已经在对准器材料上开发(即,聚对苯二甲酸乙二醇酯,PETG)通过简单可行的甲基丙烯酸缩水甘油酯(GMA)辅助涂层策略。通过GMA的开环反应将聚(GMA-co-SBMA)接枝到胺化的PETG表面上(即,“接枝到”方法以获得G-co-S涂层),或通过自由基聚合在GMA接枝的PETG表面上形成聚SBMA层(即,“从接枝”方法获得G-g-S涂层)。G-co-S和G-g-S涂层显著降低了PETG表面的摩擦系数。蛋白质吸附,细菌粘附,并且在G-co-S-和G-g-S-涂覆表面上的生物膜形成被显著抑制。在空气或人工唾液中储存2周后,涂层的性能保持稳定。两种涂层在体外均表现出良好的生物相容性,并且在体内2周内不会对大鼠的口腔粘膜产生刺激。这项研究提出了一种有希望的策略,用于开发具有改进性能的隐形对准器,有利于口腔健康治疗。本文受版权保护。保留所有权利。
Invisible aligners have been widely used in orthodontic treatment but still present issues with plaque formation and oral mucosa abrasion, which can lead to complicated oral diseases. To address these issues, hydrophilic poly(sulfobetaine methacrylate) (polySBMA) coatings with lubricating, antifouling, and antiadhesive properties have been developed on the aligner materials (i.e., polyethylene terephthalate glycol, PETG) via a simple and feasible glycidyl methacrylate (GMA)-assisted coating strategy. Poly(GMA-co-SBMA) is grafted onto the aminated PETG surface via the ring-opening reaction of GMA (i.e., \"grafting to\" approach to obtain G-co-S coating), or a polySBMA layer is formed on the GMA-grafted PETG surface via free radical polymerization (i.e., \"grafting from\" approach to obtain G-g-S coating). The G-co-S and G-g-S coatings significantly reduce the friction coefficient of PETG surface. Protein adsorption, bacterial adhesion, and biofilm formation on the G-co-S- and G-g-S-coated surfaces are significantly inhibited. The performance of the coatings remains stable after storage in air or artificial saliva for 2 weeks. Both coatings demonstrate good biocompatibility in vitro and is not caused irritation to the oral mucosa of rats in vivo over 2 weeks. This study proposes a promising strategy for the development of invisible aligners with improved performance, which is beneficial for oral health treatment.