背景:这是一项前瞻性研究,旨在研究一种新型眼用溶液的抗菌功效,该溶液包含在脂质体中的臭氧化葵花籽油和羟丙甲纤维素以及脂质体泡沫(BlefOX)。在接受玻璃体内注射的患者中,与聚维酮碘5%相比。
方法:本研究采用双眼设计,共195例患者,共390只眼,分为两组。在基线(注射前T0-3天)从每个患者的双眼收集结膜拭子。研究组接受了家庭治疗,其中包括每天4次滴注两滴含有0.5%臭氧化葵花籽油的脂质体和羟丙甲纤维素(Ozodrop)的等渗眼用溶液,并每天两次将脂质体泡沫应用于玻璃体内注射的眼睛。相比之下,对照组(对侧眼)接受5%聚维酮碘治疗.该治疗方案维持3天。在T1(注射前10分钟),所有患者均向双眼结膜囊内滴入1滴5%聚维酮碘局部溶液.30秒后,在两个研究组中,每只眼睛均获得结膜拭子.
结果:结果,来自结膜拭子,在巧克力琼脂和血琼脂上,研究组的微生物负荷显着降低(p≤0.007)。研究表明,在两种巧克力琼脂上,聚维酮碘5%+Ozodrop+BlefOX的组合比单独的聚维酮碘5%提供了更大的微生物负荷减少(141[72.31%]与98[50.26%],p<0.0001)和血琼脂(130[66.67%]vs.97[49.74%],p=0.0007)。聚维酮碘5%+Ozodrop+BlefOX的组合导致杀死约41%至49%的细菌,而在巧克力琼脂和血琼脂上单独使用聚维酮碘5%,分别。
结论:脂质体臭氧化油治疗,再加上脂质体泡沫,在接受玻璃体内注射的患者中,与单纯接受5%聚维酮碘治疗的眼部相比,结膜微生物负荷显著减少.
BACKGROUND: This was a prospective study to investigate the antimicrobial efficacy of a novel ophthalmic solution comprising ozonated sunflower oil in liposomes plus hypromellose in conjunction with liposomal foam (BlefOX), in patients undergoing intravitreal injection, in comparison to povidone iodine 5%.
METHODS: The study employed a paired-eye design with n = 195 patients and a total of n = 390 eyes divided into two groups. Conjunctival swabs were collected from both eyes of each patient at baseline (T0-3 days before the injection). The study group underwent home therapy, which included instilling two drops of an isotonic ophthalmic solution containing 0.5% ozonated sunflower oil in liposomes plus hypromellose (Ozodrop) four times daily and applying liposomal foam twice daily to the eye undergoing intravitreal injections. In contrast, the control group (contralateral eyes) received treatment with povidone iodine 5%. This treatment regimen was maintained for 3 days. At T1 (10 min before injection), all patients instilled one drop of a topical solution of povidone iodine 5% into the conjunctival sac of both eyes. After 30 seconds had elapsed, a conjunctival swab was obtained for each eye in both study groups.
RESULTS: The results, derived from conjunctival swabs, exhibited a significant reduction in the microbial load of the study group on both chocolate agar and blood agar (p ≤ 0.007). The study demonstrated that the combination of povidone iodine 5% + Ozodrop + BlefOX provides a greater reduction in microbial load than povidone iodine 5% alone on both chocolate agar (141 [72.31%] vs. 98 [50.26%], p < 0.0001) and blood agar (130 [66.67%] vs. 97 [49.74%], p = 0.0007). The combination of povidone iodine 5% + Ozodrop + BlefOX resulted in the killing of approximately 41% to 49% of bacteria compared to povidone iodine 5% alone on the chocolate agar and blood agar, respectively.
CONCLUSIONS: Liposomal ozonated oil treatment, coupled with liposomal foam, in patients undergoing intravitreal injection led to a substantial reduction in conjunctival microbial load compared to eyes treated solely with povidone iodine 5%.