intraoperative complications

术中并发症
  • 文章类型: Case Reports
    非眼科手术后的围手术期视力丧失是一种罕见但潜在的严重并发症。虽然它在泌尿外科的发生很少,对患者的后果和法律影响是显著的。我们介绍了一名53岁的女性,没有明显的病史,治疗肾结石。输尿管镜检查后,患者的视力突然下降。诊断为后部缺血性视神经病变。这种情况说明了与输尿管镜检查相关的罕见并发症,强调提高认识和严格的术后监测的重要性,尤其是有贫血或高血压等危险因素的患者。幸运的是,患者的快速和完全康复是令人鼓舞的,提示早期识别和适当的管理可以导致良好的预后。
    Perioperative vision loss following non-ophthalmic surgical procedures represents a rare but potentially serious complication. Although its occurrence in urology is infrequent, the consequences for patients and legal implications are significant. We present the case of a 53-year-old woman with no notable medical history, treated for renal lithiasis. Following the ureteroscopy, the patient experienced a sudden reduction in visual acuity. The diagnosis made was that of posterior ischemic optic neuropathy. This case illustrates a rare complication associated with ureteroscopy, highlighting the importance of increased awareness and rigorous postoperative monitoring, especially in patients with risk factors such as anemia or hypertension. Fortunately, the patient\'s rapid and complete recovery is encouraging, suggesting that early identification and appropriate management can lead to a favorable prognosis.
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  • 文章类型: Journal Article
    背景:有效的技术和非技术技能对于外科医生提供最佳的患者护理是必要的。这项研究的目的是评估普外科患者的非技术技能(NOTSS)与术后结局之间的关系。
    方法:这项前瞻性观察研究是在一个单一的,大,城市,2022年2月至9月在美国的学术医院。两名评估者(一名观察员和一名护士)在3至5次不同的手术中评估了每个参与的外科医生。患者结果数据收集自伊利诺伊州手术质量改进协作(ISQIC)数据库。我们使用美国外科医生学会国家质量改进计划(ACSNSQIP)方法来计算风险调整后的并发症。使用稳健的线性回归模型来评估外科医生的非技术技能与风险调整后的术后并发症之间的关联。
    结果:在研究中观察到的45名外科医生中,25例(55.5%)的患者结局数据由ISQIC数据库捕获。调整后的分析发现,NOTSS分数每增加一个单位,有显著的5.1(95%CI:-8.1;-2.0,p=0.003),降低任何术后并发症的调整风险,调整后的死亡风险显著降低1.1(95%CI:-1.8;-0.2,p=0.01),和显着1.1(95%CI:-1.9;-0.4,p=0.005)减少调整后的风险返回手术室。
    结论:较高的外科医生非技术技能评分与任何术后并发症的风险调整率降低相关。死亡率,回到手术室.改善术后患者预后的策略应包括提高外科医生的非技术技能。
    BACKGROUND: Effective technical and nontechnical skills are necessary for surgeons to provide optimal patient care. The aim of this study was to assess the relationship between Nontechnical Skills for Surgeons (NOTSS) and postoperative outcomes among general surgery patients.
    METHODS: This prospective observational study was conducted at a single, large, urban, academic hospital in the USA from February to September 2022. Two raters (an observer and a nurse) assessed each participating surgeon during 3 to 5 different operations. Patient outcome data were collected from the Illinois Surgical Quality Improvement Collaborative (ISQIC) database. We used the American College of Surgeons National Quality Improvement Program (ACS NSQIP) method to calculate risk-adjusted complications. Robust linear regression models were used to assess the association between surgeons\' nontechnical skills and risk-adjusted postoperative complications.
    RESULTS: Of the 45 surgeons who were observed in the study, 25 (55.5%) had patient outcome data captured by the ISQIC database. The adjusted analysis found that for every unit increase in the NOTSS score, there was a significant 5.1 (95% CI: -8.1; -2.0,p = 0.003), decrease in the adjusted risk of any postoperative complication, a significant 1.1 (95% CI: -1.8; -0.2, p = 0.01) decrease in the adjusted risk of mortality, and significant 1.1 (95% CI: -1.9; -0.4, p = 0.005) decrease in adjusted risks of returning to the operating room.
    CONCLUSIONS: Higher surgeons\' nontechnical skills scores were associated with a decreased risk-adjusted rate of any postoperative complication, mortality, and return to the operating room. Strategies to improve postoperative patient outcomes should include the improvement of surgeons\' nontechnical skills.
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  • 文章类型: Journal Article
    目的:评估基于眼前节光学相干断层扫描(AS-OCT)的晶状体术前评估的可能性,以预防和预测后囊下白内障(PSC)手术的术中并发症。
    方法:这项前瞻性研究包括512只诊断为PSC的眼睛。使用Line进行AS-OCT,交叉线和3D角膜扫描以可视化后囊。皮质下和皮质晶状体后囊和混浊,他们的关系和后透镜状空间的状态进行了评估。将研究样品分为三组,同时考虑到晶状体中显示的形态变化。第1、2和3组包括312、185和15只眼睛,分别,每组特征在于PSC中特定类型(1、2或3)的形态学AS-OCT变化。手术包括超声超声乳化和人工晶状体植入。进行了与白内障手术阶段相关的众所周知的措施,如果需要,为了保持后囊的完整性,同时考虑到PSC更改的类型。我们术前确定了手术中后囊膜破裂(PCR)和后囊膜斑块(PCP)检测的风险,并将此数据与后囊状态的术后数据进行了比较。
    结果:术中并发症的预期发生率为0%至10%的PSC病例被归类为低风险病例,而其余的,有很高的并发症风险。预期只有2型或3型PSC改变的眼睛具有术中PCP的高风险。只有3型PSC变化的眼睛,PCR的高风险。在第1、2和3组中,术中PCP的发生率为0%,100%和46.7%,分别,术中PCR的速率,0%,0%和53.3%,分别。术前基于OCT的晶状体形态与术中并发症呈正相关(r=0.88,p≤0.001)。基于AS-OCT的PSC术中并发症风险评估方法的敏感性和特异性分别为98.8%和96.5%,分别。
    结论:AS-OCT允许评估术前晶状体后混浊形态和后囊改变,确定并发症的风险,并为PSC进行手术计划。
    结论:什么是已知的?并发症(后囊(PC)破裂伴或不伴玻璃体丢失和残留的PC斑块)在,并影响预期的结果,后囊下白内障(PSC)手术。什么是新的?PC斑块在PSC术前2型改变的眼睛中最有可能,而术前3型改变的眼睛可能显示PC破裂或残留的PC斑块。AS-OCT使经验丰富的外科医生能够预测术中并发症的风险,并进行手术计划,PSC手术.
    OBJECTIVE: To assess the possibility of anterior segment optical coherence tomography (AS-OCT)-based preoperative evaluation of the lens in order to prevent and predict intraoperative complications of posterior subcapsular cataract (PSC) surgery.
    METHODS: This prospective study included 512 eyes diagnosed with PSC. AS-OCT was performed using Line, Cross Line and 3D Cornea scans to visualize the posterior capsule. The posterior capsule and opacities in the subcortical and cortical lens, their relationship and the state of the retrolenticular space were assessed. The study sample was divided into three groups while taking into account the revealed morphological changes in the lens. Groups 1, 2, and 3 comprised 312, 185 and 15 eyes, respectively, with each group characterized by a specific type (1, 2 or 3) of morphological AS-OCT changes in the PSC. Surgery consisted of ultrasound phacoemulsification with intraocular lens implantation. Well-known measures related to cataract surgery stages were performed, if required, to preserve the integrity of the posterior capsule, while taking into account the type of PSC changes. We preoperatively determined the eyes at risk for intraoperative posterior capsular rupture (PCR) and detection of posterior capsular plaque (PCP), and compared this data with the postoperative data on the state of the posterior capsule.
    RESULTS: The PSC cases with an expected rate of intraoperative complications of 0 to 10% were classified as those with a low risk, whereas the rest, with a high risk of complications. Only eyes with type 2 or type 3 PSC changes were expected to have a high risk of intraoperative PCP, and only eyes with type 3 PSC changes, a high risk of PCR. In groups 1, 2 and 3, the rates of intraoperative PCP were 0%, 100% and 46.7%, respectively, and the rates of intraoperative PCR, 0%, 0% and 53.3%, respectively. There was a significant positive correlation between preoperative OCT-based morphology of the lens and intraoperative complications (r = 0.88, p ≤0.001). Sensitivity and specificity for the method of AS-OCT-based evaluation of risks of intraoperative complications in PSC surgery were 98.8% and 96.5%, respectively.
    CONCLUSIONS: AS-OCT allows evaluating preoperatively posterior lens opacification morphology and posterior capsular changes, determining the risks of complications, and performing surgical planning for PSC.
    CONCLUSIONS: What is Known? Complications (posterior capsule (PC) rupture with or without vitreous loss and residual PC plaque) are common in, and affect the expected outcome of, posterior subcapsular cataract (PSC) surgery. What is new? PC plaque is most likely in eyes with preoperative type 2 changes in the PSC, whereas eyes with preoperative type 3 changes are likely to show PC rupture or residual PC plaque. AS-OCT enables an experienced surgeon to predict the risks of intraoperative complications in, and perform surgical planning for, PSC surgery.
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  • 文章类型: Journal Article
    目的:股骨假体周围骨折(PFF)是全髋关节置换术(THA)的重要并发症。尽管生物力学研究表明,制备股骨管的技术起着一定的作用,很少有临床研究报道这可能如何影响骨折风险。这项研究比较了无水泥THA中使用齿形器械进行压实和拉削之间的断裂风险。
    方法:使用从一家高容量医院的质量登记册中前瞻性收集的数据。包括使用Corail茎(DePuySynthes)的所有主要关节置换术。所有发生在术后前90天内的股骨骨折均纳入分析。我们确定了压实与拉削相比维持PFF的相对风险,并对混杂因素进行了调整(性别,年龄组,BMI,和使用带领茎)使用多变量泊松回归。
    结果:在2009年11月至2023年5月之间进行的6,788例主要THA可用于分析。66%为女性,平均年龄为65.0岁。手术后的前90天发生了129例(1.9%)骨折,压实组92例(2.3%),拉削组37例(1.3%)。与拉削组相比,压实组的未调整相对骨折风险为1.82(95%置信区间[CI]1.25-2.66),而调整后的相对危险度为1.70(CI1.10-2.70)。
    结论:在手术后90天内,与拉伤(2.3%对1.3%)相比,压实与更多的假体周围骨折相关。
    OBJECTIVE:  Periprosthetic femoral fracture (PFF) is a significant complication of total hip arthroplasty (THA). Although biomechanical studies have indicated that the technique by which the femoral canal is prepared plays a role, few clinical studies have reported on how this might affect the fracture risk. This study compares the fracture risk between compaction and broaching with toothed instruments in cementless THA.
    METHODS: Prospectively collected data from the quality register of a high-volume hospital was used. All primary arthroplasties using the Corail stem (DePuy Synthes) were included. All femoral fractures occurring within the first 90 days after the operation were included in the analysis. We determined the relative risk of sustaining PFF with compaction compared with broaching and adjusted for confounders (sex, age group, BMI, and use of a collared stem) using multivariable Poisson regression.
    RESULTS:  6,788 primary THAs performed between November 2009 and May 2023 were available for analysis. 66% were women and the mean age was 65.0 years. 129 (1.9%) fractures occurred during the first 90 days after the operation, 92 (2.3%) in the compaction group and 37 (1.3%) in the broaching group. The unadjusted relative risk of fracture in the compaction group compared with the broaching group was 1.82 (95% confidence interval [CI] 1.25-2.66), whereas the adjusted relative risk was 1.70 (CI 1.10-2.70).
    CONCLUSIONS: Compaction was associated with more periprosthetic fractures than broaching (2.3% versus 1.3%) within 90 days after surgery.
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  • 文章类型: Journal Article
    这项研究的主要目的是开发一种经过验证的分类系统,用于评估全髋关节置换术(THA)期间的医源性骨创伤和软组织损伤。次要目标是使用此分类系统比较常规THA(COTHA)与机械臂辅助THA(ROTHA)中的宏观骨创伤和软组织损伤。
    这项研究包括30个COTHA和30个ROTHA,由一名外科医生进行。在植入髋臼组件之前,获得了骨髋臼和髋臼周围软组织的术中照片,用于开发拟议的分类系统。评估了所提出的分类系统的观察者间和观察者内的变异性。
    全髋关节置换术(BOSTIHip)中的BOne创伤和软组织损伤分类系统对THA期间的骨髋臼创伤和关节周围肌肉损伤进行分级。对于观察者之间的协议,分类系统的类别间相关系数为0.90(95%CI0.86至0.93),对于观察者内部协议,分类系统的类别间相关系数为0.89(95%CI0.84至0.93)。与COTHA相比,ROTHA与改善的BOSTI髋关节评分(p=0.002)和前上(p=0.001)和后上(p<0.001)髋臼象限的原始骨表面更多相关。关于臀中肌损伤,两组之间没有差异(p=0.084),闭孔内(p=0.241),梨状肌(p=0.081),优等生(p=0.116),劣等游戏(p=0.132),股方肌(p=0.208),和股外侧肌(p=0.135),但与COTHA相比,ROTHA的总体合并肌肉损伤减少(p=0.023)。
    提出的BOSTIHip分类提供了一种可重复的分级系统,用于在THA期间对医源性骨创伤和软组织损伤进行分层。ROTHA与BOSTI髋关节评分改善有关,更原始的骨髋臼表面,与COTHA相比,关节周围肌肉联合损伤减少。需要进一步的研究来了解这些术中发现是否转化为治疗组之间临床结果的差异。
    UNASSIGNED: The primary objective of this study was to develop a validated classification system for assessing iatrogenic bone trauma and soft-tissue injury during total hip arthroplasty (THA). The secondary objective was to compare macroscopic bone trauma and soft-tissues injury in conventional THA (CO THA) versus robotic arm-assisted THA (RO THA) using this classification system.
    UNASSIGNED: This study included 30 CO THAs versus 30 RO THAs performed by a single surgeon. Intraoperative photographs of the osseous acetabulum and periacetabular soft-tissues were obtained prior to implantation of the acetabular component, which were used to develop the proposed classification system. Interobserver and intraobserver variabilities of the proposed classification system were assessed.
    UNASSIGNED: The BOne trauma and Soft-Tissue Injury classification system in total Hip arthroplasty (BOSTI Hip) grades osseous acetabular trauma and periarticular muscle damage during THA. The classification system has an interclass correlation coefficient of 0.90 (95% CI 0.86 to 0.93) for interobserver agreement and 0.89 (95% CI 0.84 to 0.93) for intraobserver agreement. RO THA was associated with improved BOSTI Hip scores (p = 0.002) and more pristine osseous surfaces in the anterior superior (p = 0.001) and posterior superior (p < 0.001) acetabular quadrants compared with CO THA. There were no differences between the groups in relation to injury to the gluteus medius (p = 0.084), obturator internus (p = 0.241), piriformis (p = 0.081), superior gamellus (p = 0.116), inferior gamellus (p = 0.132), quadratus femoris (p = 0.208), and vastus lateralis (p = 0.135), but overall combined muscle injury was reduced in RO THA compared with CO THA (p = 0.023).
    UNASSIGNED: The proposed BOSTI Hip classification provides a reproducible grading system for stratifying iatrogenic bone trauma and soft-tissue injury during THA. RO THA was associated with improved BOSTI Hip scores, more pristine osseous acetabular surfaces, and reduced combined periarticular muscle injury compared with CO THA. Further research is required to understand if these intraoperative findings translate to differences in clinical outcomes between the treatment groups.
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  • 文章类型: Journal Article
    背景:由于潜在的炎症,克罗恩病(CD)的手术被认为具有更多的并发症,免疫抑制,和营养不良。我们试图利用标准化的围手术期方案研究在高容量三级中心的CD患者和癌症患者中进行右侧结肠切除术的结果。
    方法:这是一项回顾性研究,研究了2013年至2022年在一家机构中所有CD患者或接受回肠结肠切除术或右半结肠切除术并回肠结肠吻合术的患者的结局。如果患者同时接受另一个程序或造口术,则将其排除在外。使用Wilcoxon秩和和卡方检验对数据进行单变量分析,以及多变量分析的逻辑回归和线性回归。
    结果:共纳入141例CD患者和589例癌症患者。患有CD的患者明显年轻,体重指数较低,合并疾病的可能性较小。包括糖尿病和高血压.患有CD的患者不太可能有吸烟史或先前的腹部手术史,但更有可能服用类固醇.两组的腹腔镜检查率相似,术中并发症,和失血。尽管术前和术中存在差异,CD患者和癌症患者的住院时间(LOS)相似,重新接纳,再操作,和死亡率。两组之间的手术结果没有显着差异。在多变量分析中,CD诊断与再次手术无关,重新接纳,死亡率,或LOS,同时控制其他特性。
    结论:使用标准化的围手术期方案,可以在具有CD专业知识的高容量中心进行CD手术,其结果与癌症等其他适应症相当。
    BACKGROUND: Surgery for Crohn\'s disease (CD) is considered to have more complications due to the underlying inflammation, immunosuppression, and malnutrition. We sought to study the outcomes of right-sided colonic resection in patients with CD and patients with cancer at a high-volume tertiary center utilizing a standardized perioperative protocol.
    METHODS: This is a retrospective study of outcomes for all patients with CD or patients undergoing ileocolic resection or right hemicolectomy with ileocolic anastomosis at a single institution from 2013 to 2022. Patients were excluded if they simultaneously underwent another procedure or ostomy creation. Data were analyzed using Wilcoxon rank-sum and chi-squared tests for univariate analyses, and logistic and linear regressions for multivariate analyses.
    RESULTS: In total 141 patients with CD and 589 patients with cancer were included. Patients with CD were significantly younger with lower body mass index and less likely to have comorbidities, including diabetes and hypertension. Patients with CD were less likely to have a smoking history or prior abdominal surgery, but more likely to be on steroids. Both groups had similar rates of laparoscopy, intraoperative complications, and blood loss. Despite the preoperative and intraoperative differences, both patients with CD and patients with cancer had similar lengths of stay (LOS), readmission, reoperation, and mortality rates. None of the surgical outcomes differed significantly between the two groups. On multivariate analysis, CD diagnosis was not associated with reoperation, readmission, mortality, or LOS while controlling for other characteristics.
    CONCLUSIONS: With the use of standardized perioperative protocols, surgery for CD at a high-volume center with expertise in CD can be performed with comparable results to other indications like cancer.
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  • 文章类型: Journal Article
    目的:低体温是剖宫产术后常见的并发症之一,严重影响孕妇术中手术安全和术后恢复。减轻剖宫产孕妇低体温的危险因素,可降低其发生概率,提高孕妇围手术期舒适度。因此,本研究系统评价剖宫产患者低体温的影响因素,旨在为剖宫产产妇低体温的预防提供参考。
    方法:在各种数据库中进行了系统搜索,包括PubMed,科克伦图书馆,Embase,WebofScience,中国国家知识基础设施(CNKI),万方,和中国生物医学文献数据库收集关于影响剖宫产孕妇体温过低因素的观察性研究。搜索截止日期为2024年1月30日。两名研究人员独立筛选文献,提取的数据,评估质量,交叉检查了结果。采用RevMan5.3和Stata17.0进行Meta分析。
    结果:本综述纳入了12项研究,所有研究均为2014-2022年进行的病例对照研究,共纳入5,561名孕妇.纳入的研究质量为平均或以上。荟萃分析结果显示,体重指数(均差(MD)=-1.47;95%置信区间(CI)[-2.84,-0.11];p=0.03),手术室温度(比值比(OR)=2.08;95%CI[1.56,2.76];p<0.00001),麻醉方法(OR=1.84;95%CI[1.40,2.42];p<0.0001),流体损失(MD=160.09;95%CI[77.31,242.87];p=0.0002),冲洗体积(MD=66.43;95%CI[8.46,124.40];p=0.02),和甲状腺功能减退(OR=2.29;95%CI[1.61,3.27];p<0.00001)是剖宫产孕妇围手术期低体温的危险因素(p<0.05)。
    结论:孕妇围手术期发生低体温受低体重指数等因素的影响,脊髓麻醉,低手术室温度,术中液体流失,冲洗量大,和甲状腺功能减退。
    OBJECTIVE: Hypothermia is one of the common complications of cesarean section, which has a serious impact on intraoperative surgical safety and postoperative recovery of pregnant women. Mitigation of the risk factors of hypothermia in pregnant women undergoing cesarean section may reduce the probability of its occurrence and improve the perioperative comfort of pregnant women. Therefore, this study systematically evaluates the influencing factors of hypothermia in patients undergoing cesarean section, aiming to provide references for the prevention of hypothermia in pregnant women undergoing cesarean section.
    METHODS: A systematic search was conducted across various databases, including PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang, and Chinese Biomedical Literature databases to gather observational studies on the factors affecting hypothermia in pregnant women undergoing cesarean section. The search deadline was January 30, 2024. Two researchers independently screened literature, extracted data, evaluated quality, and crosschecked the outcomes. Meta analysis was conducted using RevMan 5.3 and Stata17.0.
    RESULTS: Twelve studies were included in this review, all of which were case-control studies conducted from 2014 to 2022, encompassing a total of 5561 pregnant women. The quality of the studies included was average or above. The meta-analysis results showed that body mass index (mean difference (MD) = -1.47; 95% confidence interval (CI) [-2.84, -0.11]; p = 0.03), operating room temperature (odds ratio (OR) = 2.08; 95% CI [1.56, 2.76]; p < 0.00001), anesthesia method (OR = 1.84; 95% CI [1.40, 2.42]; p < 0.0001), fluid loss (MD = 160.09; 95% CI [77.31, 242.87]; p = 0.0002), flushing volume (MD = 66.43; 95% CI [8.46, 124.40]; p = 0.02), and hypothyroidism (OR = 2.29; 95% CI [1.61, 3.27]; p < 0.00001) were risk factors for perioperative hypothermia in pregnant women undergoing cesarean section (p < 0.05).
    CONCLUSIONS: The occurrence of hypothermia in pregnant women during the perioperative period is influenced by factors such as low body mass index, spinal anesthesia, low operating room temperature, intraoperative fluid loss, large flushing volume, and hypothyroidism.
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  • 文章类型: Journal Article
    腹腔镜子宫切除术近年来已成为越来越广泛使用的手术。这项研究的目的是评估在一个中心接受腹腔镜子宫切除术治疗良性或恶性适应症的患者的临床特征和围手术期结果。
    回顾性分析了在大学医院妇科肿瘤科接受腹腔镜子宫切除术的患者的数据。根据良性或恶性适应症的手术形成两组。评估了这些组的人口统计学特征和围手术期数据。
    共有1515例患者接受了腹腔镜子宫切除术。患者的平均年龄为52.0±9.8岁,平均BMI为31.3±8.5kg/m2。其中,1,219例良性,296例恶性组织病理学结果。在整个队列中,术中并发症为1.6%,术后并发症为3.5%。恶性组患者年龄较大,有较高的体重指数,和更高的共病率。该组的手术时间和住院时间明显更长(所有参数p=0.0001)。然而,术中和术后并发症发生率,两组的输血率和输血量相似(p>0.05)。
    在良性和恶性指征中,腹腔镜子宫切除术的并发症发生率低,不管病人的促成因素。然而,因为经验很重要,应支持财政资源和人员培训过程。
    Laparoscopic hysterectomy has become an increasingly used surgery in recent years. The aim of this study was to evaluate the clinical features and perioperative outcomes of patients who underwent laparoscopic hysterectomy for benign or malignant indications in a single center during a period of eight years.
    Data of patients who underwent laparoscopic hysterectomy in the gynecological oncology department of a university hospital over a period of eight years was analyzed retrospectively. Two groups were formed based on being operated for benign or malignant indications. Demographic characteristics and perioperative data of these groups were evaluated.
    A total of 1,515 patients underwent laparoscopic hysterectomy. The mean age of the patients was 52.0±9.8 years and mean body mass index (BMI) was 31.3±8.5 kg/m2. Of these, 1,219 had benign and 296 had malignant histopathology results. In the whole cohort, intraoperative complications were seen in 1.6% and postoperative complications in 3.5%. The patients in the malignant group were older, had a higher BMI and a higher comorbidity rate. The duration of operation and length of hospital stay were significantly longer in this group (p=0.0001 for all parameters). However, intraoperative and postoperative complication rates, rate of blood transfusion and amount of transfusion were similar between the two groups (p>0.05).
    Laparoscopic hysterectomy can be performed with low complication rates in benign and malignant indications, regardless of the patient’s contributing factors. However, since experience is important, financial resources and personnel training processes should be supported.
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  • 文章类型: Journal Article
    目的:本研究旨在阐明与先天性膈疝(CDH)开放手术相关的手术并发症。
    方法:我们对2006年至2021年间行开腹或开胸手术的CDH新生儿的手术并发症的临床特征进行了探索性数据分析。这些患者的数据来自日本CDH研究组的数据库。
    结果:在1,111名患有左或右CDH的新生儿中,852接受了开腹手术(剖腹手术或开胸手术)。在这852名新生儿中,51例具有以下手术并发症:器官损伤(n=48;开放手术的6%);器官位置变化引起的循环衰竭(n=2);和皮肤烧伤(n=1)。受伤的器官包括脾脏(n=30;器官损伤的62%),肝脏(n=7),肺(n=4),肠(n=4),肾上腺(n=2),和胸壁(n=2)。经历器官损伤的患者中有14例需要输血(开放手术的2%)。非直接闭合膈肌的脾损伤的调整比值比为2.2(95%可信区间,1.1-4.9)。
    结论:在接受CDH开放手术的患者中,2%的人经历了需要输血的器官损伤。非直接闭合膈缺损是脾损伤的危险因素。
    OBJECTIVE: This study aimed to clarify surgical complications associated with open surgery for congenital diaphragmatic hernia (CDH).
    METHODS: We performed an exploratory data analysis of the clinical characteristics of surgical complications of neonates with CDH who underwent laparotomy or thoracotomy between 2006 and 2021. Data of these patients were obtained from the database of the Japanese CDH Study Group.
    RESULTS: Among 1,111 neonates with left or right CDH, 852 underwent open surgery (laparotomy or thoracotomy). Of these 852 neonates, 51 had the following surgical complications: organ injury (n = 48; 6% of open surgeries); circulatory failure caused by changes in the organ location (n = 2); and skin burns (n = 1). Injured organs included the spleen (n = 30; 62% of organ injuries), liver (n = 7), lungs (n = 4), intestine (n = 4), adrenal gland (n = 2), and thoracic wall (n = 2). Fourteen of the patients who experienced organ injury required a blood transfusion (2% of open surgeries). The adjusted odds ratio of splenic injury for patients with non-direct closure of the diaphragm was 2.2 (95% confidence interval, 1.1-4.9).
    CONCLUSIONS: Of the patients who underwent open surgery for CDH, 2% experienced organ injury that required a blood transfusion. Non-direct closure of the diaphragmatic defect was a risk factor for splenic injury.
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  • 文章类型: Journal Article
    据报道,背景普遍,术中低血压(IOH)与肾损伤和死亡风险增加相关.在这项研究中,我们旨在评估高危非心脏手术中IOH的发生率及其与术后急性肾损伤(PO-AKI)和术后30天死亡率的相关性.方法这项回顾性队列研究包括接受择期治疗的成年住院患者,非心脏,2020年10月至11月,2021年和2022年的高风险欧洲麻醉学会/欧洲心脏外科学会,不包括心脏,颅内,或紧急手术。IOH主要由2022年麻醉质量研究所定义。PO-AKI定义为48小时内血清肌酐增加≥0.3mg/dL,透析初期患者需要透析,或在临床记录中记录AKI。对于单变量分析,进行了曼-惠特尼U检验和卡方或费舍尔精确检验,视情况而定。单因素分析采用Logistic回归检验IOH的危险因素(p<0.1)。在多变量分析中考虑的显著性水平为5%。结果在197例患者中,111人(56.3%)经历了IOH。调整后,手术时间>120分钟仍然与较高的IOH几率相关(优势比(OR)=9.62,95%置信区间(CI)=2.49-37.13),以及综合一般+局部区域(与一般OR=3.41,95CI%=1.38-8.43,p=0.008;与局部OR=6.37,95%CI=1.48-27.47)。IOH与术后30天死亡率(p=0.565)或PO-AKI(p=0.09)之间无相关性。PO-AKI发生率为14.9%(27例),与术后30天死亡率显著相关(p=0.018)。结论我们的研究强调了IOH在高风险非心脏手术中的高患病率。与PO-AKI的重要影响相比,其对PO-AKI和术后30天死亡率的影响似乎不那么明显。强调PO-AKI筛查和肾脏保护策略的必要性。
    Background Reportedly prevalent, intraoperative hypotension (IOH) is linked to kidney injury and increased risk of mortality. In this study, we aimed to assess IOH incidence in high-risk non-cardiac surgery and its correlation with postoperative acute kidney injury (PO-AKI) and 30-day postoperative mortality. Methodology This retrospective cohort study included adult inpatients who underwent elective, non-cardiac, high-risk European Society of Anaesthesiology/European Society of Cardiology surgery from October to November of 2020, 2021, and 2022, excluding cardiac, intracranial, or emergency surgery. IOH was primarily defined by the 2022 Anesthesia Quality Institute. PO-AKI was defined as an increase in serum creatinine ≥0.3 mg/dL within 48 hours, the need for dialysis in dialysis-naïve patients, or the documentation of AKI in clinical records. For univariate analysis, the Mann-Whitney U test and chi-square or Fisher\'s exact tests were performed, as appropriate. Logistic regression was used to test risk factors for IOH in univariate analysis (p < 0.1). The significance level considered in multivariate analysis was 5%. Results Of the 197 patients included, 111 (56.3%) experienced IOH. After adjustment, surgical time >120 minutes remained associated with higher odds of IOH (odds ratio (OR) = 9.62, 95% confidence interval (CI) = 2.49-37.13), as well as combined general + locoregional (vs. general OR = 3.41, 95 CI% = 1.38-8.43, p = 0.008; vs. locoregional OR = 6.37, 95% CI = 1.48-27.47). No association was found between IOH and 30-day postoperative mortality (p = 0.565) or PO-AKI (p = 0.09). The incidence of PO-AKI was 14.9% (27 patients), being significantly associated with higher 30-day postoperative mortality (p = 0.018). Conclusions Our study highlights the high prevalence of IOH in high-risk non-cardiac surgical procedures. Its impact on PO-AKI and 30-day postoperative mortality appears less pronounced compared to the significant implications of PO-AKI, emphasizing the need for PO-AKI screening and renal protection strategies.
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