intralesional steroid injection

  • 文章类型: Journal Article
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  • 文章类型: Case Reports
    狭窄性腱鞘炎是一种以纤维骨隧道内的肌腱的炎症和收缩为特征的病症。
    我们介绍了一个38岁的男子,他出现了哈耳盐,这种情况的罕见表现,已通过病灶内类固醇注射成功治疗。患者在手术后经历了疼痛的显著缓解和功能的改善。
    该案例强调了将狭窄性腱鞘炎视为拇指盐的潜在原因以及非手术干预措施在其管理中的有效性的重要性。
    UNASSIGNED: Stenosing tenosynovitis is a condition characterized by the inflammation and constriction of the tendons within a fibro-osseous tunnel.
    UNASSIGNED: We present a case of a 38-year-old man who presented with hallux saltans, a rare manifestation of this condition which was successfully treated with intralesional steroid injection. The patient experienced significant relief from pain and improved function following the procedure.
    UNASSIGNED: This case highlights the importance of considering stenosing tenosynovitis as a potential cause of hallux saltans and the efficacy of non-surgical interventions in its management.
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  • 文章类型: Case Reports
    病灶内注射类固醇可避免与全身给药相关的潜在副作用,如下丘脑-垂体-肾上腺轴抑制,内分泌变化,过敏反应,晕厥,和失明,但不要避免局部副作用,如疼痛,出血,溃疡,萎缩,色素沉着减退,钙化,继发感染,肉芽肿形成,和过敏反应。病灶内类固醇后的线性白斑病是一种罕见但已知的并发症。这里,我们报道了一例23岁女性患者,在一次注射曲安奈德治疗神经节囊肿3个月后,出现了沿左前臂掌侧的皮肤线性脱色。
    Intralesional steroid injections avoid potential side effects associated with systemic administration, such as hypothalamus-pituitary-adrenal axis suppression, endocrine changes, allergic reactions, syncope, and blindness, but do not spare local side effects, such as pain, hemorrhage, ulceration, atrophy, hypopigmentation, calcification, secondary infection, granuloma formation, and allergic reaction. Linear leukoderma following intralesional steroid is a rare but known complication. Here, we report a case of a 23-year-old female presented with cutaneous linear depigmentation along the volar aspect of her left forearm developed three months following a single episode of injection triamcinolone acetonide for ganglion cyst.
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  • 文章类型: Journal Article
    目的:喉气管狭窄(LTS)的特征是上气道直径异常减小。肺功能测试(PFT)是上呼吸道阻塞的有效辅助诊断工具。LTS可以通过开放手术或侵入性较小的内窥镜方法进行管理,其中内窥镜球囊扩张是主要方法;这可能包括同时病灶内注射类固醇(ILSI),有可能改善结果。然而,ILSI的有效性尚不清楚。我们旨在比较接受和未接受ILSI的内窥镜球囊扩张术后获得LTS的患者PFT参数的改善。我们还比较了两个患者队列之间的复发时间和发生率。方法:我们回顾性收集了关于术前和术后PFTs的数据,以及扩张间隔记录,在2015年6月至2020年4月期间获得。结果:我们纳入了34例获得性病因患者。狭窄的最常见原因是插管(52.9%),其次是创伤(29.4%)。Further,52.9%的患者接受了ILSI。23例(67.6%)出现症状复发,组间无显著差异-0.1389[95%置信区间(CI):-0.4483,0.1705]。在接受和未接受ILSI的患者中,首次再干预的平均(标准差)持续时间为8.62(8.00)和7.38(3.20)个月,分别(平均差-1.23,P=.614,95%CI-6.30,3.84)。结论:我们的发现表明内镜下球囊扩张后PFT参数改善,在并发ILSI的情况下,1秒内用力呼气量明显更高。然而,治疗效果无方法间差异.此外,再狭窄复发率与文献报道一致.
    Objectives: Laryngotracheal stenosis (LTS) is characterized by an abnormal decrease in the upper airway diameter. The pulmonary function test (PFT) is an effective adjunctive diagnostic tool for upper airway obstruction. LTS can be managed with either open surgery or less invasive endoscopic approaches, among which endoscopic balloon dilation is the main method; this may include concurrent intralesional steroid injection (ILSI), which has the potential of improving the outcomes. However, the effectiveness of ILSI is unclear. We aimed to compare the improvement in PFT parameters among patients with acquired LTS following endoscopic balloon dilation who received and did not receive ILSIs. We also compared the recurrence times and rates between the 2 patient cohorts. Methods: We retrospectively collected data regarding pre- and postoperative PFTs, as well as inter-dilation interval records, obtained between June 2015 and April 2020. Results: We included 34 patients with acquired etiologies. The most common cause of stenosis was intubation (52.9%), followed by trauma (29.4%). Further, 52.9% of the patients received ILSIs. Symptom recurrence was reported in 23 (67.6%) cases, with no significant between-group difference -0.1389 [95% confidence interval (CI): -0.4483, 0.1705]. The mean (standard deviation) duration of the first reintervention was 8.62 (8.00) and 7.38 (3.20) months among patients who did and did not receive ILSIs, respectively (mean difference -1.23, P = .614, 95% CI -6.30, 3.84). Conclusion: Our findings indicated that PFT parameters improved following endoscopic balloon dilation, with forced expiratory volume in 1 second being significantly higher with concurrent ILSI. However, there was no between-method difference in the treatment effectiveness. Additionally, the restenosis recurrence rate was consistent with that reported in the literature.
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  • 文章类型: Journal Article
    病灶内注射类固醇最近发展成为局部特发性肉芽肿性乳腺炎(=IGM)的新治疗方式。我们旨在探讨局部类固醇注射(LSI)对严重IGM患者的治疗效果。
    51例被诊断为严重IGM的患者被纳入研究,并单独使用局部类固醇注射(LSI)(n=25)或LSI联合全身口服类固醇治疗(OST)(n=26)。局部类固醇注射方案包括每4周将曲安奈德病灶内注射到可触知的肉芽肿中,并在受影响的乳房表面上每天两次局部施用含类固醇的润发。联合使用LSI和OST的患者接受低剂量口服甲基强的松龙(<16mg)。
    单独使用LSI的患者比使用LSI和OST的患者需要更多的LSI应用(LSI:5±2.9;与LSI/OST:3.5±2.5;p=0.080)以获得有效的最佳治疗反应。中位数为12个月(范围,4-42),LSI组和合并有OST的LSI组患者的完全缓解率无差异(52vs.53.9%,p=0.999)。然而,单纯LSI组类固醇相关的全身副作用较低(p<0.008).
    对于患有严重IGM的患者,局部注射类固醇可被视为一线治疗,直到作为唯一的治疗方式或与口服类固醇联合获得治疗反应。与全身口服类固醇治疗相比,局部使用类固醇可被认为是一种副作用较少的新治疗方式.
    UNASSIGNED: Intralesional steroid injection has recently evolved as a novel treatment modality for localized idiopathic granulomatous mastitis (= IGM). We aimed to explore the therapeutic efficacy of local steroid injections (LSI) in patients with severe IGM.
    UNASSIGNED: Fifty-one patients diagnosed with severe IGM were included in the study and treated with either local steroid injection (LSI) alone (n = 25) or combined LSI with systemic oral steroid treatment (OST) (n = 26). The local steroid injection protocol included an intralesional triamcinolone acetonide injection into the palpable granulomas every 4-week, and topical administration of steroid-containing pomades twice a day on the affected surface of the breast. Patients with a combined LSI and OST received low-dose oral methylprednisolone (<16 mg).
    UNASSIGNED: Patients with LSI alone required more LSI applications than those in the combined LSI with OST group (LSI: 5 ± 2.9; vs. LSI/OST: 3.5 ± 2.5; p = 0.080) to obtain an effective optimum therapeutic response. At a median of 12 months (range, 4-42), no difference was found in complete response rates between patients in the LSI group and the combined LSI group with OST (52 vs. 53.9%, p = 0.999). However, steroid-related systemic side effects were lower in the LSI alone group (p < 0.008).
    UNASSIGNED: Local steroid injection could be considered as the first-line treatment in patients with severe IGM until a therapeutic response has been obtained either as the sole treatment modality or combined with oral steroids. Compared with systemic oral steroid therapy, local steroid administration can be considered a new treatment modality with fewer side effects.
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  • 文章类型: Journal Article
    耳廓的假性囊肿是一种软骨内病变,定义为无菌的积聚,未被上皮覆盖的囊肿中的稻草色液体。这在男性中更为常见。最常见的病变部位是舟骨窝和右耳。尽管病因尚不清楚,它可能与机械刺激有关,反复的轻伤和慢性创伤.如果不及时治疗,它会导致耳廓永久畸形。耳廓假性囊肿是一种罕见且具有挑战性的疾病。不幸的是,医疗管理没有显示实际结果。因此,手术治疗方式是最佳选择。治疗的普遍目的是保护和恢复耳廓的解剖结构,切除囊性病变和预防复发。在大多数情况下,简单的抽吸或切开和引流会导致囊性液体的再积聚。切开引流技术最简单,但复发率高。保守治疗通常会导致复发和效果不理想。其他治疗方式包括切口和每日冲洗引流,耳廓夹板,病灶内注射类固醇抽吸,抽吸,然后加压敷料,或通过病灶内注射类固醇进行抽吸,然后进行加压敷料和手术脱毛,手术脱毛,然后用纽扣或薄片或三明治方法压迫。直径小于1厘米的囊肿通过非手术治疗方式处理,而对于直径大于1厘米的囊肿,手术被认为是首选疗法。这些治疗方案已显示出有希望的结果。传统技术的各种修改降低了复发率,成功治疗了这种情况,并显示出良好的美容效果。这篇综述文章旨在提供各种常规治疗方式和引入的新颖修改的整体集合,可用于一系列确定的耳廓血清肿治疗。
    The pseudocyst of the auricle is an intracartilaginous lesion defined as the accumulation of sterile, straw-coloured fluid in a cyst unlined by epithelium. It is more common in males. The most common site of lesion is the scaphoid fossa and right ear. Though the aetiology remains unclear, it may be associated with mechanical irritation, repeated minor injuries and chronic trauma. If left untreated, it can lead to permanent deformity of the auricle. Pseudocyst of the auricle is a rare and challenging condition. Medical management has unfortunately shown no practical results. Hence, surgical treatment modalities are the best option. The universal aim of treatment is the conservation and restoration of the anatomical structure of the pinna, removal of cystic lesions and prevention of recurrence. Simple aspiration or incision and drainage alone lead to reaccumulation of cystic fluid in most cases. The technique of incision and drainage is the easiest but has a high recurrence rate. Conservative treatment often results in recurrence and unsatisfactory results. Other treatment modalities include incision and drainage with daily irrigation, auricular splinting, aspiration with intralesional steroid injection, aspiration followed by compression dressing, or aspiration with intralesional steroid injection followed by compression dressing and surgical deroofing, surgical deroofing followed by compression with buttons or sheet or sandwich method. Cysts with a diameter less than 1 cm are dealt with through non-surgical treatment modalities, while for cysts having a diameter greater than 1 cm, surgery is considered as first choice therapy. These treatment options have shown promising results. Various modifications in the traditional techniques have reduced the recurrence rate, successfully treated the condition and shown good cosmetic results. This review article aims at providing a holistic collection of various conventional treatment modalities and novel modifications introduced, which can be used in a sequence of definitive treatments of seroma of the auricle.
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  • 文章类型: Journal Article
    Benign esophageal strictures are one of the common clinical conditions managed by endoscopists. Nearly 90% of the benign esophageal strictures respond to endoscopic dilation. However, a small percentage of patients progress to recalcitrant strictures. The benign recalcitrant esophageal strictures are difficult to manage both medically and endoscopically as they do not respond to conventional treatment with proton pump inhibitors and esophageal dilations. Patients with benign recalcitrant esophageal strictures are at a high risk of developing debilitating malnutrition and morbidity due to severe dysphagia. This condition is associated with psychological trauma to patients as treatments are usually prolonged with poor outcomes. Also, this can be a financial burden on the healthcare industry due to several sessions of treatment. In this article, we discuss the classification of benign esophageal strictures, evidence-based treatment strategies, endoscopic procedural techniques, and complications of endoscopic interventions. We aim to guide providers in managing benign esophageal strictures with a focus on endoscopic management of benign recalcitrant esophageal strictures.
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  • 文章类型: Journal Article
    OBJECTIVE: To assess the incidence and severity of 12 systemic side effects of serial intralesional steroid injections (SILSI) in patients with idiopathic subglottic stenosis (iSGS).
    METHODS: This retrospective study included patients with iSGS who underwent SILSI with Triamcinolone 40 mg/dL. After SILSI, the patients were asked to answer 12 questions regarding frequently encountered systemic side effects of steroids. Each answer was rated as mild, moderate, or severe. Descriptive statistics were used to analyze and present the findings.
    RESULTS: The study included 49 patients (42 female and 7 male) with a mean age of 59.1 years (range 21-83 years). Post-SILSI treatment, 27 (55%) reported experiencing side effects while 22 (45%) patients reported no side effects. The most frequent side effect reported in women of reproductive age (n: 8) was menstrual irregularities (3/8, 37%). Other frequently reported side effects were feeling joyful and sleeping difficulties, each reported by 30% of the patients. All side effects resolved after the completion of SILSI.
    CONCLUSIONS: SILSI can be administered with minimal tolerable side effects. Clinicians should make their patients aware of the most frequent side effects. Special attention should be given to women of reproductive age to inform them of the possibility of menstrual irregularities during SILSI.
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  • 文章类型: Journal Article
    BACKGROUND: Approaches to improve keloid scars include intralesional corticosteroid injections and fractional lasers exclusively. The combinative use of ablative fractional laser therapy and occluded topical corticosteroid as a drug delivery method enhances therapeutic outcome of two efficient scar therapy modules into one simple synergistic module.
    OBJECTIVE: To compare the therapeutic effect of combining two modalities of scar treatment, the first is fractional ablative laser treatment and the other is occluded topical corticosteroid to the standard use of intralesional steroid injection.
    METHODS: Keloids from thirty suffering patients were split faced into two identical parts; one part received an intralesional corticosteroid injection while the other part was treated first with fractional ablative 2940 nm Er: YAG laser followed by occluded topical application of steroid cream. Four treatment sessions were performed with 4-week interval between sessions. Every session was assessed photographically and using the Vancouver Scar Scale (VSS).
    RESULTS: The mean keloid VSS before treatment was 6.9 ± 1.9. After treatment, the mean keloid VSS of the injection side became 2.63 ± 2.09, and mean keloid VSS of the laser-treated side became 2.07 ± 2.02. Each of the treated halves showed a statistically significant improvement in their VSS. However, no statistically significant differences were observed for either of the treated halves over the other one.
    CONCLUSIONS: Although intralesional steroids injection is the standard procedure for treatment of keloid scars, the use of ablative fractional laser-assisted delivery of topical steroid can offer a safer and a better aesthetic treatment option.
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    文章类型: Journal Article
    UNASSIGNED: Auricular seroma is a benign condition of the pinna usually following blunt trauma. This condition which presents with a simple swelling of the pinna is occasionally associated with pain and may result in permanent disfigurement of the pinna owing to delay in diagnosis or mismanagement. Various techniques have been proposed and practiced over the years to treat this uncomplicated condition. However, since this condition is notorious for its recurrence, it has always posed a challenge to the ear, nose, and throat surgeons. Therefore, a simple technique known as aspiration and intralesional steroid injection was proposed in this study for the treatment of auricular seroma.
    UNASSIGNED: A total of 30 patients with a clinical diagnosis of auricular seroma were studied over a period of six years at a tertiary care hospital in Mangalore, India. The seroma was aspirated with a 22 gauge needle followed by intralesional injection of Triamcinolone acetate (40 mg/1 ml). The patients were followed up strictly for two weeks, one, three, and six months, as well as one year, and thereafter at yearly intervals as long as possible. No recurrence was observed as the main outcome of treatment for at least one year.
    UNASSIGNED: None of our patients had recurrence at the end of one year. In total, 15 patients followed up for at least two years. In addition, four patients are continuing follow-ups at the moment (i.e. six years post-treatment).
    UNASSIGNED: Aspiration and intralesional steroid injection is a simple, minimally invasive, cost-effective, and a promising treatment modality which avoids recurrence.
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