背景:依恋理论为理解人际互动经验提供了重要的框架。在本研究中,我们使用fMRI检查了精神分裂症患者(SZP)与健康对照组(HC)的依恋模式和催产素的神经相关性。我们假设与HC相比,男性SZP显示出更高的不安全依恋比例和催产素水平改变。在神经层面,我们假设与HC相比,SZP在附着系统激活过程中在记忆和自我相关脑区显示出神经激活增加。
方法:我们在fMRI研究中使用了与事件相关的设计,该设计基于来自成人依恋投射图像系统的刺激,以检查20名男性精神分裂症患者与20名男性健康对照的依恋表现及其神经和激素相关性。
结果:可以证实,与HC相比,精神分裂症患者中不安全依恋的比例更高。根据我们的假设,SZP中的催产素(OXT)水平显着低于HC。我们发现在SZP中,当面对与个人相关的句子,然后在前脑中附加相关图片时,大脑激活增加,TPJ,脑岛,与HC相比,额叶面积。此外,我们发现OXT和双边dlPFC之间存在正相关,precuneus,并仅在SZP中离开ACC。
结论:尽管样本量很小,当面对这种个性化的依恋相关材料时,患者的反应可能被认为是一种失调的模式。在病人组中,我们发现OXT和三个大脑区域(双侧dlPFC,precuneus,左ACC),并可以得出结论,OXT可能会在SZP中的该神经网络内进行调节。
BACKGROUND: Attachment theory offers an important framework for understanding interpersonal interaction experiences. In the present study, we examined the neural correlates of attachment patterns and oxytocin in schizophrenic patients (SZP) compared to healthy controls (HC) using fMRI. We assumed that male SZP shows a higher proportion of insecure attachment and an altered level of oxytocin compared to HC. On a neural level, we hypothesized that SZP shows increased neural activation in memory and self-related brain regions during the activation of the attachment system compared to HC.
METHODS: We used an event-related design for the fMRI study based on stimuli that were derived from the Adult Attachment Projective Picture System to examine attachment representations and their neural and hormonal correlates in 20 male schizophrenic patients compared to 20 male healthy controls.
RESULTS: A higher proportion of insecure attachment in schizophrenic patients compared to HC could be confirmed. In line with our hypothesis, Oxytocin (OXT) levels in SZP were significantly lower than in HC. We found increasing brain activations in SZP when confronted with personal relevant sentences before attachment relevant pictures in the precuneus, TPJ, insula, and frontal areas compared to HC. Moreover, we found positive correlations between OXT and bilateral dlPFC, precuneus, and left ACC in SZP only.
CONCLUSIONS: Despite the small sample sizes, the patients\' response might be considered as a mode of dysregulation when confronted with this kind of personalized attachment-related material. In the patient group, we found positive correlations between OXT and three brain areas (bilateral dlPFC, precuneus, left ACC) and may conclude that OXT might modulate within this neural network in SZP.