■酒渣鼻是一种慢性炎症性皮肤病。先前的研究已经确定IL-36、IL-37和IL-38可能在各种炎性疾病的发病机理中起作用。
■本研究旨在评估这些细胞因子与酒渣鼻的关系。
■总共100个人,包括50名酒渣鼻患者和50名健康对照者,包括在研究中。IL-36、IL-37和IL-38水平使用ELISA方法通过从所有参与者采集血清样品来测量。
■患者组血清中IL-36、IL-37和IL-38的平均水平为52.17±24.07pg/ml,18.46±8.18pg/ml,25.74±8.36纳克/升,分别。对照组血清IL-36、IL-37、IL-38水平分别为32.99±19.90pg/ml,44.61±22.27pg/ml,45.61±17.32纳克/升,分别。患者组与对照组血清IL-36、IL-37、IL-38水平差异有统计学意义(P<0.001)。
■基于这些发现,IL-36的增加以及IL-37和IL-38的减少可能与酒渣鼻的发病机理有关。未来的酒渣鼻治疗可以靶向和/或与酒渣鼻发病机理中的这些可能步骤相互作用。
UNASSIGNED: Rosacea is a chronic inflammatory skin disease. Previous studies have determined that IL-36, IL-37, and IL-38 may play a role in the pathogenesis of various inflammatory diseases.
UNASSIGNED: The present study aims to evaluate the relationship of these cytokines with rosacea.
UNASSIGNED: A total of 100 individuals, including 50 patients with rosacea and 50 healthy controls, were included in the study. IL-36, IL-37, and IL-38 levels were measured using the ELISA method by taking serum samples from all participants.
UNASSIGNED: The mean serum levels of IL-36, IL-37, and IL-38 in the patient group were 52.17 ± 24.07 pg/ml, 18.46 ± 8.18 pg/ml, and 25.74 ± 8.36 ng/l, respectively. The mean serum levels of IL-36, IL-37, and IL-38 in the control group were 32.99 ± 19.90 pg/ml, 44.61 ± 22.27 pg/ml, and 45.61 ± 17.32 ng/l, respectively. The difference between the serum levels of IL-36, IL-37, and IL-38 in the patient and control groups was statistically significant (P < 0.001).
UNASSIGNED: Based on these findings, an increase in IL-36 and a decrease in IL-37 and IL-38 may contribute to the pathogenesis of rosacea. Future rosacea treatments could target and/or interact with these possible steps in the pathogenesis of rosacea.