■Interlukin-15(IL-15)是一种炎性细胞因子,在免疫学和肥胖相关的代谢综合征中起着至关重要的作用。我们进行了这项系统评价和荟萃分析,以调查运动是否促进成人循环IL-15浓度。
■我们搜索了PubMed,WebofScience,和Scopus从成立到五月,2023年,并确定了原始研究,调查了急性和/或慢性运动对成人血清/血浆IL-15水平的有效性。使用随机效应模型计算标准化平均差(SMD)和95%置信区间(CI)。根据运动类型进行亚组分析,和培训状况,参与者的健康状况和体重指数(BMI)。
■15项研究包括411名参与者和12项研究包括899名参与者在急性和慢性运动分析中。分别。我们的发现表明,与基线相比,急性运动后立即增加循环IL-15浓度[SMD=0.90(95%CI:0.47至1.32),p=0.001],无论运动类型和参与者的培训状态。同样,即使运动后一小时,急性运动也与IL-15浓度增加相关[SMD=0.50(95%CI:0.00至0.99),p=0.04]。然而,长期运动对IL-15浓度没有显着影响[SMD=0.40(95%CI:-0.08至0.88),p=0.10]。
■我们的结果证实,急性运动在运动干预后立即和一小时内有效增加IL-15浓度,从而在改善成人新陈代谢方面发挥潜在作用。
■https://www.crd.约克。AC.uk/prospro/display_record.php?RecordID=445634,标识符CRD42023445634。
Interlukin-15 (IL-15) is an inflammatory cytokine that plays a vital role in immunology and obesity-associated metabolic syndrome. We performed this systematic review and meta-analysis to investigate whether exercise promotes circulating IL-15 concentrations in adults.
We searched PubMed, Web of Science, and Scopus from inception to May, 2023 and identified original studies that investigated the effectiveness of acute and/or chronic exercise on serum/plasma IL-15 levels in adults. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated using random effect models. Subgroup analyses were performed based on type of exercise, and training status, health status and body mass indexes (BMI) of participants.
Fifteen studies involving 411 participants and 12 studies involving 899 participants were included in the acute and chronic exercise analyses, respectively. Our findings showed that acute exercise increased circulating IL-15 concentrations immediately after exercise compared with baseline [SMD=0.90 (95% CI: 0.47 to 1.32), p=0.001], regardless of exercise type and participants\' training status. Similarly, acute exercise was also associated with increased IL-15 concentrations even one-hour after exercise [SMD=0.50 (95% CI: 0.00 to 0.99), p=0.04]. Nevertheless, chronic exercise did not have a significant effect on IL-15 concentrations [SMD=0.40 (95% CI: -0.08 to 0.88), p=0.10].
Our results confirm that acute exercise is effective in increasing the IL-15 concentrations immediately and one-hour after exercise intervention, and thereby playing a potential role in improving metabolism in adults.
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=445634, identifier CRD42023445634.