Interval-training is widely implemented among populations with obesity to decrease metabolic-disorders; however, high-intensity-interval-training (HIIT) has rarely been studied in severely obese adolescent girls. Therefore, the aim of this study was to compare the effects of 8 weeks of (HIIT) or moderate-intensity interval-training (MIIT), on cardiometabolic risk factors and hormonal-ratios in severely-obese-girls. For this aim, 35 female-adolescents (14.4 ± 1.4 years) were assigned randomly into HIIT (n = 12) and MIIT (n = 12), groups and a control group (CG, n = 11). Both training groups significantly improved (p < 0.05): the body-mass, body-mass-index (BMIp95), body-fat (BF%), waist-circumference (WC), mean-arterial-pressure (MAP), with a slight increase in the HIIT group. However, HIIT induced greater improvements on the maximal oxygen uptake (VO2MAX) and the speed related (24.7 and 11.8%) compared to MIIT. Higher improvements occurred in HIIT group related to leptin and adiponectin concentrations and the A/L ratio at (p < 0.001). In conclusion, the findings indicate that both HIIT and MIIT can positively influence body composition and cardio-respiratory fitness. Given the significant correlation noted between the A/L ratio, BMIp95, BF%, and MAP post-HIIT, this training modality may be considered a more advantageous approach over MIIT for mitigating cardio-metabolic issues in severely obese adolescent girls.

The purpose of this study was to observe changes in iron metabolism of rats due to high-intensity exercise during reduced food intake.
Thirty-six, 4-wk-old male Wistar rats were divided into six groups after being acclimated to running: rested control, intense exercise, 80% feeding and rested, 80% feeding and intense exercise, 70% feeding diet and rested, and 70% feeding and intense exercise groups. Only three intense exercise groups underwent acute running sessions for 30 min (30 m/min) once a day for 7 d.
Rats did not develop anemia with exercise and food intake restriction. Serum iron levels, transferrin saturation, hepcidin-25, and hepatic iron levels in the exercise groups were lower than those in the respective resting groups. However, these values in the 70% diet groups were slightly higher than those in the 80% diet groups. Serum erythropoietin levels decreased as food intake decreased, but the serum erythropoietin level in the 70% feeding and intense exercise group was similar to that in the rested control group. Serum interleukin-6 levels were significantly lower in the groups with restricted food intake than in the free-fed group, and exercise had no effect.
High-intensity exercise under restricted food intake may significantly alter the iron metabolism to maintain blood cell levels due to the strong promotion of metabolic iron utilization in response to dietary iron depletion, increased iron demand, and excretion.

Alzheimer\'s disease (AD) is the most common and irreversible neurodegenerative disorder, and amyloid peptide plays a central role in its pathogenesis. Physical training contributes as a beneficial adaptation to AD. However, these effects may be underestimated because much of the literature used fixed training prescription variables (intensity and volume) throughout the protocol. Moreover, researchers poorly understand whether chronic high-intensity interval training (HIIT) exerts similar effects on the brain tissue of individuals with AD.
This study evaluated the effect of 8 minutes of HIIT with incremental overload in an AD model.
Forty male Wistar rats were divided into four groups: an untrained Sham group, Sham trained group, Aβ1-42 (Alzheimer\'s) untrained group, and Aβ1-42 (Alzheimer\'s) trained group (n=10 rats per group). Animals underwent stereotactic surgery and received a hippocampal injection of Aβ1-42 or a saline solution. Seven days after surgery, two weeks of treadmill adaptation followed by a maximal running test (MRT) was performed. Then, animals were subjected to eight weeks of HIIT. Rats were sacrificed 24 h after the behavioral tests (open field and Morris water maze), hippocampal tissue was extracted to analyze the redox balance and BDNF/TrkB pathway, and neuritic plaques (NP) were detected by evaluating silver impregnation.
The AD trained group presented a physical capacity amelioration every two weeks and locomotor, learning, and memory improvements (p<0.05). These effects were accompanied by increased CAT and SOD levels, followed by decreased lipid peroxidation (p<0.05). Furthermore, increased activation of the BDNF/TrkB (p<0.05) pathway and decreased NP was observed.
Based on these results, MRT was essential for an excellent chronic training protocol prescription and overload adjustment. Therefore, 8 minutes of HIIT daily for 8 weeks may reduce behavioral deficits by promoting a positive redox balance and increased activity of the BDNF/TrkB pathway that may contribute to NP attenuation.

This study explored the effect of running exercises at low [30% heart rate reserve (HRR)] and moderate (60%HRR) intensities on cognitive performances in individuals with intellectual disability (ID).
Participants performed randomly reaction time (RT) tests: visual RT [simple RT (SRT) and choice RT (CRT)], auditory SRT (ASRT) and working memory (WM) (Corsi test) before and after the exercises.
The results showed that after both exercises, SRT decreased significantly (P < 0.001) in both groups with higher extent (P < 0.05) at 60%HRR compared with 30%HRR. CRT decreased (P < 0.01), similarly, after the both exercises in both groups with higher (P < 0.001) extent in the intellectual disability group (IDG). ASRT decreased significantly, at 30%HRR, in IDG (P < 0.001) and in control group (CG) (P < 0.01) with greater extent in IDG (P < 0.001). At 60%HRR, ASRT decreased significantly in both groups (P < 0.001) with greater extent in IDG (P < 0.001). The ΔASRT% was significantly (P < 0.05) higher at 30%HRR compared with 60%HRR in IDG. In CG, no significant (P = 0.21) difference was reported between intensities. The Corsi forward and the Corsi backward scores increased significantly (P < 0.01) in both groups after both intensities with higher extent in IDG (P < 0.01).
Our results suggest that low and moderate running exercises improve similarly simple and choice visual RT as well as WM in individuals with ID. Furthermore, low-intensity exercise could be more appropriate to enhance ASRT compared the moderate one in these individuals. Therefore, low-intensity exercise seems to be an efficient strategy to improve cognitive performances in individuals with ID.

OBJECTIVE: To investigate the training and detraining effects of two different hypoxic high-intensity protocols on cardiorespiratory fitness, maximal fat oxidation and energy contribution in obese women.
METHODS: 82 obese women completed a 12-week training of: (1) interval training in hypoxia (IHT; n = 19; 3 min at 90%Wmax: 3 min at 55-65%Wmax; FiO2 = 17.2%), (2) interval training in normoxia (INT; n = 20; 3 min at 90%Wmax: 3 min at 55-65%Wmax), (3) repeated sprint training in hypoxia (RSH; n = 22; 30 s at 130%Wmax: 3 min at 55-65%Wmax; FiO2 = 17.2%), and (4) repeated sprint training in normoxia (RSN; n = 21; 30 s at 130%Wmax: 3 min at 55-65%Wmax). VO2max, workload, time to exhaustion and heart rate were assessed at baseline, after completion of 36 training sessions over 12 weeks and after 4 weeks of detraining.
RESULTS: Hypoxic training (IHT and RSH) showed a significant positive effect on absolute (p < 0.001) and relative maximal oxygen uptake (p < 0.001) as well as VT2 (%VO2max; p < 0.001). Both IHT and RSH showed significantly higher values of absolute VO2max (IHT: + 26.63%; RSH: + 19.79%) and relative VO2max (IHT: + 27.95%; RSH: + 19.94%) between baseline and post-exercise (p < 0.001). VO2max (IHT: + 21.74%; RSH: + 17.65%) and relative VO2max (IHT: + 23.53%; RSH: + 17.15%) remained significantly higher after detraining in IHT and RSH (p < 0.001).
CONCLUSIONS: A larger improvement in cardiorespiratory fitness has been observed after high-intensity interval training under normobaric hypoxia. As interval training or repeated sprint training did not show a significant effect, RSH might provide a time-metabolic effective strategy in this population.

OBJECTIVE: Low-volume, high-intensity exercise is a time-efficient method of inducing physiological responses and may also improve glucose homeostasis. Therefore, effects of two different volumes of sprint-interval cycling on post-prandial blood glucose were assessed.
METHODS: Twenty healthy young males undertook two Wingate anaerobic tests (2WAT), four Wingate anaerobic (4WAT) and without-exercise (CON) 90 min after eating a standard meal. Blood glucose was examined at 60, 90, 105, 120, 135 and 150 min post-prandially.
RESULTS: 2WAT and 4WAT both accelerated the decrease of blood glucose compared with CON (P<0.05). There were significant reductions at 120 (4.45 ± 0.64 vs. 4.93 ± 0.9 vs. 5.68 ± 0.69), 135 (4.28 ± 0.50 vs. 4.48 ± 0.75 vs. 5.54 ± 0.6) and 150 min (4.64 ± 0.71 vs. 4.71 ± 0.73 vs. 5.36 ± 0.48, all P<0.05). Blood glucose at 120 min was lower after 2WAT than 4WAT (4.45 ± 0.64 vs. 4.93 ± 0.9, P<0.05), this producing a significant statistical interaction between groups and post-exercise time (P<0.005).
CONCLUSIONS: 2WAT and 4WAT tests both accelerate the post-prandial decrease in blood glucose in young healthy males, 2WAT being superior to 4WAT in producing this response, even though 2WAT is easier to perform and less time consuming.