■先前的研究表明,血清白蛋白与前列腺癌(PCa)有关,但在没有PCa病史的人群中,前列腺特异性抗原(PSA)水平没有。因此,我们分析了国家健康和营养调查(NHANES)(2003-2010)提供的次要数据.
■总共,从NHANES数据库(2003-2010)中选择了5,469名参与者。血清白蛋白和PSA水平被连续认为是独立和因变量,连续。本研究中包括了一些协变量,包括人口统计,饮食,体检,和合并症数据。采用加权线性回归模型和平滑曲线拟合,研究了血清白蛋白与PSA之间的线性和非线性关系。
■在调整了潜在的干扰因素后,加权多元线性回归分析显示,血清白蛋白不能独立预测PSA水平(β=-0.00995CI:-0.020,0.002).然而,血清白蛋白和PSA之间存在非线性关系,点41克/升拐点的左边,效果大小,95CI和P值分别为0.019(log2转化)(-0.006,0.043)和0.1335。我们在拐点右侧发现血清白蛋白和PSA呈负相关,效果大小,95CI,P值为-0.022(log2变换)(-0.037,-0.007),0.0036.
■总之,血清白蛋白和PSA水平不呈线性关系。当血清白蛋白水平超过41克,血清白蛋白水平与PSA水平呈负相关。
Previous studies have shown that serum albumin is associated with prostate cancer (PCa), but not with prostate-specific antigen (PSA) levels in populations without PCa history. Therefore, we analyzed secondary data provided by the National Health and Nutrition Examination Survey (NHANES) (2003-2010).
In total, 5,469 participants were selected from the NHANES database (2003-2010). Serum albumin and PSA levels were serially considered independent and dependent variables, serially. A number of covariates were included in this study, including demographic, dietary, physical examination, and comorbidity data. Using weighted linear regression model and smooth curve fitting, the linear and non-linear relationship between serum albumin and PSA was investigated.
After modulating underlying interference factors, the weighted multivariate linear regression analysis revealed that serum albumin did not independently predict PSA levels (β = -0.009 95%CI: -0.020, 0.002). Nevertheless, a non-linear relationship was found between serum albumin and PSA, with a point of 41 g/L. Left of the inflection point, the effect size, 95%CI, and P-value were 0.019 (log2 transformation) (-0.006, 0.043) and 0.1335, respectively. We found a negative association between serum albumin and PSA on the right side of the inflection point, with effect size, 95%CI, and a P-value of -0.022 (log2 transformation) (-0.037, -0.007), 0.0036.
In summary, serum albumin and PSA levels are not linearly related. When serum albumin levels exceed 41 g, serum albumin levels are negatively associated with PSA levels.