目的:本研究的目的是研究放射治疗(RT)对炎症性肠病(IBD)患者胃肠道毒性的临床影响。
背景:IBD长期以来被认为是RT引起肠毒性增加的危险因素;然而,关于前列腺癌(PC)和IBD患者的证据很少。
方法:对1990-2013年的IBD和PC患者进行肿瘤登记查询。对接受RT的患者进行回顾性审查。收集放射治疗和毒性数据。
结果:平均随访时间为12年(中位数为9.54,范围为0.42-19.9)。在医疗管理中,大多数人的基线肠功能得到了很好的控制。在辐射之前,60%的患者(9/15)和40%(6/15)在基线时报告了0级(G0)和G1级腹泻,分别。无基线直肠炎。放射治疗后,78%(14/18)的患者出现G0腹泻,而22%(4/18)的患者报告了G1腹泻。无患者发生大于G1期的腹泻。百分之六十六(12/18),17%(3/18)和17%(3/18)的患者经历了G0,G1和G2直肠炎,分别。没有患者发生放射后狭窄形成,所有G2直肠炎患者均接受3dCRT治疗。
结论:有限的已发表数据可用于探索PC和IBD患者的RT。该分析为罕见患者子集的适当咨询提供了有价值的见解。辐射改善了晚期G1期腹泻率。仅在3dCRT患者中遇到2级直肠炎。无放疗后并发症发生。我们的发现表明,在基于IMRT的RT时代,IBD患者的毒性最小。
OBJECTIVE: The study\'s aim was to examine the clinical impact of radiation therapy (RT) on GI toxicity in Inflammatory Bowel Disease (IBD) patients.
BACKGROUND: IBD has long been considered a risk factor for increased bowel toxicity from RT; however, minimal evidence exists on patients with prostate cancer (PC) and IBD.
METHODS: The tumor registry was queried for patients with IBD and PC from the years 1990-2013. A retrospective review was conducted for patients who received RT. Radiation treatment and toxicity data were collected.
RESULTS: Average length of follow-up was 12 years (median 9.54, range 0.42-19.9). The majority had well controlled baseline bowel function on medical management. Prior to radiation, 60% of patients (9/15) and 40% (6/15) reported grade 0 (G0) and grade (G1) diarrhea at baseline, respectively. No baseline proctitis existed. Following radiation treatment, 78% (14/18) of patients experienced G0 diarrhea while 22% (4/18) reported G1 diarrhea. No patients suffered from greater than G1 diarrhea. Sixty-six percent (12/18), 17% (3/18) and 17% (3/18) of patients experienced G0, G1, and G2 proctitis, respectively. No patients suffered post-radiation stricture formation, and all patients with G2 proctitis received 3dCRT.
CONCLUSIONS: Limited published data is available exploring RT for patients with PC and IBD. This analysis offers valuable insight into appropriate counseling for a rare patient subset. Radiation improved late G1 diarrhea rates. Grade 2 proctitis was only encountered in 3dCRT patients. No post-radiation complications occurred. Our findings suggest that IBD patients experience minimal toxicity in the era of IMRT based RT.