■饮食摄入与炎症性关节炎(IA)的风险和严重程度之间的因果关系目前尚不清楚。
■在这项研究中,我们旨在使用孟德尔随机化(MR)研究9种饮食类别(30种饮食)与IA之间的因果关系.
■我们在全基因组关联研究(GWAS)中分析了来自30种饮食和IA的数据。可影响MR分析结果的单核苷酸多态性(SNPs)通过孟德尔随机化PleiotropionSresidualSum和离群值(MR-PRESSO)检验进行筛选。SNP通过双样本双向MR使用逆方差加权进行分析,MR-Egger回归,和加权中位数法。使用MR-Egger截距项检验和Cochran'sQ检验评估SNP的多重性和异质性。使用FDR校正来校正p值。
■IVW结果表明,牛肉摄入量[赔率(OR)=2.862;95%置信区间(CI),1.360-6.021,p=0.006,p_fdr<0.05]与类风湿关节炎(RA)呈正相关;干果摄入量(OR=0.522;95%CI,0.349-0.781,p=0.002,p_fdr<0.05),铁摄入量(OR=0.864;95CI,0.777-0.960,p=0.007,p_fdr<0.05)与RA呈负相关,所有这些都是意义的证据。新鲜水果摄入量(OR=2.528。95%CI,1.063-6.011,p=0.036,p_fdr>0.05)与银屑病关节炎(PsA)呈正相关;奶酪摄入量(OR=0.579;95%CI,0.367-0.914,p=0.019,p_fdr>0.05)与PsA呈负相关;两者均为提示证据。加工肉类摄入量(OR=0.238;95%CI,0.100-0.565,p=0.001,p_fdr<0.05)与反应性关节炎(ReA)呈负相关,保护因素,和重要的证据。所有暴露数据均通过异质性检查(Cochrane的Q检验p>0.05),未检测到方向性多效性。留一法分析证明了积极结果中因果关系的稳健性。
■我们的研究提供了遗传证据支持饮食与IA风险增加之间的因果关系。它还确定了各种饮食方式和不同类型IA之间的因果关系。这些发现对通过饮食调整预防和管理IA具有重要意义。
UNASSIGNED: The causal associations between dietary intake and the risk and severity of Inflammatory Arthritis (IA) are currently unknown.
UNASSIGNED: In this study, we aimed to investigate the causal relationship between nine dietary categories (30 types of diet) and IA using Mendelian randomization (MR).
UNASSIGNED: We analyzed data from 30 diets and IA in a genome-wide association study (GWAS). Single nucleotide polymorphisms (SNPs) that could influence the results of MR analyses were screened out through the Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test. SNPs were analyzed through two-sample bidirectional MR using inverse variance weighting, MR-Egger regression, and weighted median method. The multiplicity and heterogeneity of SNPs were assessed using MR-Egger intercept term tests and Cochran\'s Q tests. FDR correction was used to correct the p-values.
UNASSIGNED: IVW results showed that Beef intake [Odds ratio (OR) = 2.862; 95% confidence interval (CI), 1.360-6.021, p = 0.006, p_fdr < 0.05] was positively associated with rheumatoid arthritis(RA); Dried fruit intake (OR = 0.522; 95% CI, 0.349-0.781, p = 0.002, p_fdr < 0.05), and Iron intake (OR = 0.864; 95%CI, 0.777-0.960, p = 0.007, p_fdr < 0.05) were negatively associated with RA, all of which were evidence of significance. Fresh fruit intake (OR = 2.528. 95% CI, 1.063-6.011, p = 0.036, p_fdr > 0.05) was positively associated with psoriatic arthritis (PsA); Cheese intake (OR = 0.579; 95% CI, 0.367-0.914, p = 0.019, p_fdr > 0.05) was negatively associated with PsA; both were suggestive evidence. Processed meat intake (OR = 0.238; 95% CI, 0.100-0.565, p = 0.001, p_fdr < 0.05) was negatively associated with reactive arthritis (ReA), a protective factor, and significant evidence. All exposure data passed the heterogeneity check (Cochrane\'s Q test p > 0.05) and no directional pleiotropy was detected. Leave-one-out analyses demonstrated the robustness of the causal relationship in the positive results.
UNASSIGNED: Our study presents genetic evidence supporting a causal relationship between diet and an increased risk of IA. It also identifies a causal relationship between various dietary modalities and different types of IA. These findings have significant implications for the prevention and management of IA through dietary modifications.