铁皮石斛多糖(DOPs)是铁皮石斛中重要的活性多糖,它通常被用作常规食品或草药,在中国是众所周知的。DOP可以影响肠道菌群的组成和这些共生细菌的降解能力,这反过来可能决定饮食干预的有效性。然而,缺乏对DOP与肠道菌群之间关系的必要分析。在这次审查中,我们总结了提取,结构,健康益处,以及DOP的相关机制,构建DOPs-宿主轴,并提出DOP是潜在的益生元,主要由1,4-β-D-甘露糖组成,1,4-β-D-葡萄糖,和O-乙酸酯基团,这导致肠道微生物群的丰度增加,如乳杆菌,双歧杆菌,Akkermansia,拟杆菌,还有Prevotella.此外,我们发现,当暴露于具有不同结构特性的DOP时,肠道微生物群可能表现出不同的多样性和组成,并提供健康益处,如新陈代谢法规,炎症调制,免疫力适度,和癌症干预。这可能有助于促进功能性食品和保健品的开发,以改善人类健康。
Dendrobium officinale polysaccharides (DOPs) are important active polysaccharides found in Dendrobium officinale, which is commonly used as a conventional food or herbal medicine and is well known in China. DOPs can influence the composition of the gut microbiota and the degradation capacity of these symbiotic bacteria, which in turn may determine the efficacy of dietary interventions. However, the necessary analysis of the relationship between DOPs and the gut microbiota is lacking. In this review, we summarize the extraction, structure, health benefits, and related mechanisms of DOPs, construct the DOPs-host axis, and propose that DOPs are potential prebiotics, mainly composed of 1,4-β-D-mannose, 1,4-β-D-glucose, and O-acetate groups, which induce an increase in the abundance of gut microbiota such as Lactobacillus, Bifidobacterium, Akkermansia, Bacteroides, and Prevotella. In addition, we found that when exposed to DOPs with different structural properties, the gut microbiota may exhibit different diversity and composition and provide health benefits, such as metabolism regulations, inflammation modulation, immunity moderation, and cancer intervention. This may contribute to facilitating the development of functional foods and health products to improve human health.