背景:急性痛风性关节炎(AGA)的特征是由关节周围组织中尿酸单钠(MSU)晶体的积聚引起的快速炎症反应。这种情况通常与高尿酸血症有关,以其剧烈疼痛的症状为特征,活动性炎症,关节肿胀.AGA管理的传统方法在临床环境中往往达不到预期的结果。然而,最近的民族药理学研究一直集中在各种形式的传统草药(THM)的潜力,探索它们在AGA治疗中的治疗作用和靶点。
目的:这篇综述简要概述了THMs目前潜在的药理机制-包括活性成分,摘录,和处方-在AGA的治疗中,并深入探讨了相关的潜在机制和分子靶标。这项研究的目的是为探索使用THMs的靶向AGA治疗提供广泛的信息和参考点。
方法:这篇综述获得了有关2013年至2023年进行的抗AGA传统草药(THMs)的体外和体内研究的科学出版物。这些文献是从各种期刊和电子数据库中收集的,包括PubMed,Elsevier,ScienceDirect,WebofScience,谷歌学者。以"急性痛风性关节炎和中草药,“急性痛风性关节炎草药处方,急性痛风性关节炎和免疫细胞,急性痛风性关节炎和炎症,\"急性痛风性关节炎和NLRP3,\"急性痛风性关节炎和miRNA,“和”急性痛风性关节炎和氧化应激。\"
结果:我们发现AGA有大量的治疗靶点,通过体外和体内研究强调THM在AGA治疗中的潜力。THMs及其活性成分可以通过多种治疗靶点缓解AGA症状,比如影响巨噬细胞极化,中性粒细胞,T细胞,自然杀伤(NK)细胞,解决炎症等因素,NLRP3炎性体,信号通路,氧化应激,和miRNA多靶点相互作用。THM的抗AGA特性,包括它们的活性成分和处方,根据各自的治疗靶点进行系统总结和分类。
结论:酚醛,类黄酮,THM中的萜类和生物碱化合物被认为是改善AGA的关键成分。THMs及其活性成分通过与多个靶标的相互作用实现增强的功效,其中NLRP3是主要的治疗靶点。尽管如此,鉴于中药复杂的成分,需要更多的研究来揭示THM缓解AGA的潜在机制和分子靶标。
BACKGROUND: Acute gouty arthritis (AGA) is characterized by a rapid inflammatory reaction caused by the build-up of monosodium urate (MSU) crystals in the tissues surrounding the joints. This condition often associated with hyperuricemia (HUA), is distinguished by its symptoms of intense pain, active inflammation, and swelling of the joints. Traditional approaches in AGA management often fall short of desired outcomes in clinical settings. However, recent ethnopharmacological investigations have been focusing on the potential of Traditional Herbal Medicine (THM) in various forms, exploring their therapeutic impact and targets in AGA treatment.
OBJECTIVE: This review briefly summarizes the current potential pharmacological mechanisms of THMs - including active ingredients, extracts, and prescriptions -in the treatment of AGA, and discusses the relevant potential mechanisms and molecular targets in depth. The objective of this study is to offer extensive information and a reference point for the exploration of targeted AGA treatment using THMs.
METHODS: This review obtained scientific publications focused on in vitro and in vivo studies of anti-AGA THMs conducted between 2013 and 2023. The literature was collected from various journals and electronic databases, including PubMed, Elsevier, ScienceDirect, Web of Science, and Google Scholar. The retrieval and analysis of relevant articles were guided by keywords such as \"acute gouty arthritis and Chinese herbal medicine,\" \"acute gouty arthritis herbal prescription,\" \"acute gouty arthritis and immune cells,\" \"acute gouty arthritis and inflammation,\" \"acute gouty arthritis and NOD-like receptor thermoprotein domain associated protein 3 (NLRP3),\" \"acute gouty arthritis and miRNA,\" and \"acute gouty arthritis and oxidative stress.\"
RESULTS: We found that AGA has a large number of therapeutic targets, highlighting the effectiveness the potential of THMs in AGA treatment through in vitro and in vivo studies. THMs and their active ingredients can mitigate AGA symptoms through a variety of therapeutic targets, such as influencing macrophage polarization, neutrophils, T cells, natural killer (NK) cells, and addressing factors like inflammation, NLRP3 inflammasome, signaling pathways, oxidative stress, and miRNA multi-target interactions. The anti-AGA properties of THMs, including their active components and prescriptions, were systematically summarized and categorized based on their respective therapeutic targets.
CONCLUSIONS: phenolic, flavonoid, terpenoid and alkaloid compounds in THMs are considered the key ingredients to improve AGA. THMs and their active ingredients achieve enhanced efficacy through interactions with multiple targets, of which NLRP3 is a main therapeutic target. Nonetheless, given the intricate composition of traditional Chinese medicine (TCM), additional research is required to unravel the underlying mechanisms and molecular targets through which THMs alleviate AGA.