目的:描述犬浸润性脂肪瘤的放疗结果并提供详细的放疗计划数据。
方法:从2000年到2020年有24只狗。
方法:在这项回顾性研究中,在常规分割放疗之前,狗接受了1至3次手术,以治疗大体(18)或显微镜(8)浸润性脂肪瘤。狗每天接受15到20分的45到51灰色(Gy),71%的狗在每日3-Gy部分中接受48Gy。
结果:群众分布如下:四肢(7),树干(13),头/颈(4)。在分析中,16/24狗死亡,5/24活着(对活狗的中位随访时间:1,216天[范围,741至1,870天]),和3/24失去了随访。一只活着的狗在完成常规分割放疗后923天患有进行性疾病,并接受了另一次手术。完成放疗后的估计中位总生存期(OS)为4.8年(1,760天;95%CI,1,215至2,777天;范围,23至3,499天)的任何死因,据报道,没有患者被安乐死或死于肿瘤。根据肉眼和显微镜下的疾病(肉眼OS,4.8年vs微观OS,3.6年;P=.45)。此外,放疗前手术次数不影响生存率(P=.96).女性之间的生存差异(中位OS,7.6岁;95%CI,963天没有达到)与男性(中位OS,4.6年;95%CI,335至2,245天;P=0.05)有统计学意义,虽然4/5活狗是雌性。
结论:这项研究表明放疗后的生存期很长,即使患有严重疾病,对于有浸润性脂肪瘤的狗.
OBJECTIVE: To describe radiotherapy outcomes for canine infiltrative lipomas and provide detailed radiotherapy planning data.
METHODS: 24 dogs from 2000 to 2020.
METHODS: In this retrospective study, dogs received 1 to 3 surgeries prior to conventionally fractionated radiotherapy for gross (18) or microscopic (8) infiltrative lipomas. Dogs received 45 to 51 Gray (Gy) in 15 to 20 daily fractions, with 71% of dogs receiving 48 Gy in daily 3-Gy fractions.
RESULTS: Masses were regionally located as follows: limbs (7), trunk (13), head/neck (4). At analysis, 16/24 dogs were deceased, 5/24 were alive (median follow-up for alive dogs: 1,216 days [range, 741 to 1,870 days]), and 3/24 were lost to follow-up. One living dog had progressive disease 923 days after completing conventionally fractionated radiotherapy and received another surgery. The estimated median overall survival (OS) after completing radiotherapy was 4.8 years (1,760 days; 95% CI, 1,215 to 2,777 days; range, 23 to 3,499 days) for any cause of death, and no patients were reported to have been euthanized or died from their tumor. No statistically significant difference was found for dogs based on gross versus microscopic disease (gross OS, 4.8 years vs microscopic OS, 3.6 years; P = .45). Furthermore, the number of surgeries before radiotherapy did not impact survival (P = .96). The survival difference between females (median OS, 7.6 years; 95% CI, 963 days to not reached) versus males (median OS, 4.6 years; 95% CI, 335 to 2,245 days; P = .05) was statistically significant, although 4/5 living dogs were female.
CONCLUSIONS: This study demonstrates lengthy survivals with radiotherapy, even with gross disease, for dogs with infiltrative lipomas.