干细胞疗法为常规药物和疗法无法有效治疗的疾病和损伤提供了有希望的解决方案。为了充分发挥其治疗潜力,归位过程,生存,分化,必须清楚地了解移植后干细胞的植入。为了满足这一需求,已经开发了基于纳米粒子(NPs)的非侵入性成像技术来追踪移植的干细胞.在这里,我们总结了现有的商业NP,它们可以作为三种常用成像模式的造影剂,包括荧光成像,磁共振成像和光声成像,用于干细胞标记和跟踪。具体来说,我们通过他们的技术,行业分销商,干细胞研究中的应用和现有问题。最后,我们提供了关于新NP产品开发的潜在挑战和未来的行业观点。
Stem cell therapy provides promising solutions for diseases and injuries that conventional medicines and therapies cannot effectively treat. To achieve its full therapeutic potentials, the homing process, survival, differentiation, and engraftment of stem cells post transplantation must be clearly understood. To address this need, non-invasive imaging technologies based on nanoparticles (NPs) have been developed to track transplanted stem cells. Here we summarize existing commercial NPs which can act as contrast agents of three commonly used imaging modalities, including fluorescence imaging, magnetic resonance imaging and photoacoustic imaging, for stem cell labeling and tracking. Specifically, we go through their technologies, industry distributors, applications and existing concerns in stem cell research. Finally, we provide an industry perspective on the potential challenges and future for the development of new NP products.