目的:微量元素(TE)无处不在。TE浓度因个人和国家而异,取决于居住面积等因素,工作场所和饮食。TEs浓度不足或过高会影响人体的正常功能,因此其生物监测很重要。该项目的目的是为瑞士人口中的TEs浓度提供参考值。
方法:纳入本研究的1,078名SCiPOGH队列参与者年龄为18-90岁。通过电感耦合等离子体质谱法(ICP-MS)分析他们的24小时尿液和/或血浆样品,以确定24个TEs浓度:Ag,Al,As,Be,Bi,Cd,Co,Cr,Cu,Hg,I,Li,Mn,Mo,Ni,Pb,Pd,Pt,Sb,Se,Sn,Tl,V和Zn。进行了统计检验以评估协变量(性别,年龄,BMI,吸烟)对这些结果。还定义了瑞士成年人口的参考间隔。
结果:分别获得了994和903人在血浆和尿液基质中的TE浓度。可以为几乎所有的TE定义感兴趣的百分位数(P50和P95)。在两个矩阵中都注意到男性和女性之间的TE分布差异;年龄也是辅助因素。
结论:这是瑞士首次对大型TEs小组进行生物监测,为瑞士人群提供了血浆和尿液的参考值。在这项研究中获得的结果通常与临床建议一致,并且与其他基于人群的调查中报告的水平相当。
OBJECTIVE: Trace elements (TEs) are ubiquitous. TE concentrations vary among individuals and countries, depending on factors such as living area, workplaces and diet. Deficit or excessive TEs concentrations have consequences on the proper functioning of human organism so their biomonitoring is important. The aim of this project was to provide reference values for TEs concentrations in the Swiss population.
METHODS: The 1,078 participants to the SKiPOGH cohort included in this study were aged 18-90 years. Their 24-h urine and/or plasma samples were analyzed by inductively coupled plasma mass spectrometry (ICP-MS) to determine 24 TEs concentrations: Ag, Al, As, Be, Bi, Cd, Co, Cr, Cu, Hg, I, Li, Mn, Mo, Ni, Pb, Pd, Pt, Sb, Se, Sn, Tl, V and Zn. Statistical tests were performed to evaluate the influence of covariates (sex, age, BMI, smoking) on these results. Reference intervals for the Swiss adult population were also defined.
RESULTS: TEs concentrations were obtained for respectively 994 and 903 persons in plasma and urine matrices. It was possible to define percentiles of interest (P50 and P95) for almost all the TEs. Differences in TEs distribution between men and women were noticed in both matrices; age was also a cofactor.
CONCLUSIONS: This first Swiss biomonitoring of a large TEs-panel offers reference values in plasma and in urine for the Swiss population. The results obtained in this study were generally in line with clinical recommendations and comparable to levels reported in other population-based surveys.