这篇关键综述描述了角鲨烯-臭氧(SqOz)反应,或角鲨烯臭氧分解。环境臭氧渗透室内并驱动室内空气化学。角鲨烯,人体皮肤油的成分,含有六个碳-碳双键,对臭氧非常敏感。来自人的生物流出物有助于室内空气化学并影响室内空气质量,导致暴露,因为人们大部分时间都在室内。SqOz反应通过各种形成途径进行,并产生包括醛,酮,羧酸,和二羰基物种,有一系列波动。在这篇关于SqOz化学的重要评论中,有关反应机理的信息,反应概率,速率常数,并编制了反应动力学。SqOz反应产物的表征已经在实验室实验和真实世界环境中完成。多个环境参数(臭氧浓度,空气交换率(AER),温度,和相对湿度(RH))在室内设置进行了总结。这一关键审查的结论是确定可用暴露的匮乏,健康,和已知反应产物的毒理学数据。提供了有关导致室内暴露和不良健康结果的SqOz反应的关键知识差距,以及该领域的发展方向。
This critical review describes the squalene-ozone (SqOz) reaction, or squalene ozonolysis. Ambient ozone penetrates indoors and drives indoor air chemistry. Squalene, a component of human skin oil, contains six carbon-carbon double bonds and is very reactive with ozone. Bioeffluents from people contribute to indoor air chemistry and affect the indoor air quality, resulting in exposures because people spend the majority of their time indoors. The SqOz reaction proceeds through various formation pathways and produces compounds that include aldehydes, ketones, carboxylic acids, and dicarbonyl species, which have a range of volatilities. In this critical review of SqOz chemistry, information on the mechanism of reaction, reaction probability, rate constants, and reaction kinetics are compiled. Characterizations of SqOz reaction products have been done in laboratory experiments and real-world settings. The effect of multiple environmental parameters (ozone concentration, air exchange rate (AER), temperature, and relative humidity (RH)) in indoor settings are summarized. This critical review concludes by identifying the paucity of available exposure, health, and toxicological data for known reaction products. Key knowledge gaps about SqOz reactions leading to indoor exposures and adverse health outcomes are provided as well as an outlook on where the field is headed.